Academic Articles & Research Papers

Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics

The aging of pancreatic beta cells is closely associated with various diseases, such as impaired glucose tolerance, yet the underlying regulatory mechanisms remain unclear. In this study, we screened young and aged mouse pancreatic beta cel...

Effectiveness of music-based interventions in acute care settings for people living with dementia to reduce anxiety and enhance the care experience: A systematic review.

Introduction: Dementia is a global health priority, with an increasing percentage of overall hospital bed days occupied by people with dementia (PWD). This combined with increased demand and availability of complex scanning means that there...

Linking Spiritual and Religious Coping With the Quality of Life of Community-Dwelling Older Adults and Nursing Home Residents

Objective: This study examined the effect of Positive and Negative Spiritual and Religious Coping (SRC) upon older Brazilian’s quality of life (QOL). Method: A secondary analysis of data collected from 77 nursing home residents (NHRs; M age...

Impact of age-friendly living environment and intrinsic capacity on functional ability in older adults: a cross-sectional study

Abstract Background The World Health Organization (WHO) has proposed healthy aging framework, supposing that intrinsic capacity (IC), environment and their interaction may have influence on functional ability (FA). It was still unclear how ...

Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration

Introduction Alzheimer’s disease and other dementias affect >50 million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort and biobank studies have played a critical role in advancing the un...

Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults

Background: Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether ...

Creating Exercise Spaces in Parks for Older Adults With Fitness, Rehabilitation, and Play Elements: A Review and Perspective

Parks usually create a protective playground space for children to perform physical activity like jumping, running, and climbing. Specific spaces have rarely been created for older adults to perform physical activity in public parks. Now th...

Watching Out for Older Drivers

Abstract Motor vehicle accidents are the leading cause of injury-related deaths among adults age 65 to 74. This risk for traffic fatalities may triple as the numbers of older drivers increases in the coming years. It is the ethical opinion ...

Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer’s Disease

The hallmarks of Alzheimer’s disease (AD) pathology are senile plaques containing amyloid-beta (Aβ) and neurofibrillary tangles containing hyperphosphorylated tau. Additional pathologies often co-exist, whereas multiple pathogenic mechanism...

Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease

Abstract Background During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator of vul...

Association between Postoperative Neck Pain and Intraoperative Transcranial Motor-Evoked Potential Waveforms of the Trapezius Muscles in Patients with Cervical Myelopathy Who Underwent Cervical Laminoplasty

Study Design Retrospective study. Purpose Cervical laminoplasty is safe and effective for treating cervical myelopathy but has a higher frequency of postoperative axial pain compared to other methods. Several studies have reported on the ca...

Investigation of Play Intervention for Dementia (PID) Activities in Addressing Cognitive Domains Reflected in Hong Kong Montreal Cognitive Assessment (HK-MoCA)

Background/Objectives: Yee Hong Play Intervention for Dementia (PID) is a community program strengthening East Asians >65 years with dementia in their daily functional activities. We analyzed how PID activities align with Hong Kong Montreal...

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

The antioxidant vitamin E (α-tocopherol, α-TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with vitamin E metabolism marked by urinary α-tocopheronolactone hydroquinone (α-TLH...

Measles IgG Antibodies: Is There a Protective Role in COVID 19 Pandemic?‎ ‎

Background and study aim: Epidemiological   data reported lower death rates of COVID-19 cases   in countries with   higher & ‎recent coverage by measles containing vaccines. In this study we aim to identify measles IgG titer ‎in COVID-1...

Exploring stress mediation: self-efficacy, sense of coherence, and self-esteem among nursing students in Poland—a multicenter cross-sectional observational study

BackgroundNursing students frequently encounter stressful and demanding situations during clinical training, which may hinder their well-being and professional development. A strong sense of coherence is thought to buffer the negative effec...

Stage-Dependent Within-Individual Comparison Reveals SIV-Specific Activation/Exhaustion Shift in Rhesus Macaques

It is challenging to trace the complicated individual-based variations of HIV-specific immunocompetence shift during the successful antiretroviral therapy (ART) era. Using eight rhesus monkeys simulating a longitudinal stage-dependent cohor...

Dementia in the old age: a gloomy wood later in life

Dementia incidence is growing at an impressive rate worldwide, mostly affecting old age subjects. Looking and considering the disease as the same in younger adult does not seem the successful way to find a proper solution regarding preventi...

Correlation between frailty and reduction in cortical thickness in patients with chronic obstructive pulmonary disease

Abstract Physical inactivity and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD) can lead to frailty and poor prognoses. However, little is known regarding the association between frailty and the human bra...

Textbook of Geriatric Medicine and Gerontology

Handbook of Social Gerontology.

Social gerontology is concerned with the phenomena of aging which are related to man as a member of the social group. This handbook is addressed to research workers, teachers, and graduate students as a text and as a guide. Over 50 colleges...