Academic Articles & Research Papers

Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt

Abstract Background Many cancers arise from mutations in cells within epithelial tissues. Mutations manifesting at the subcellular level influence the structure and function of the tissue resulting in cancer. Previous work has proposed how ...

Association of androgen receptor and tumour-infiltrating lymphocytes with bone recurrence in triple-negative breast cancer

Background: As compared to endocrine responsive breast cancer bone is less frequent site of distant recurrence in triple-negative breast cancer (TNBC). A biomarker which predicts bone recurrence would allow a more personalized treatment app...

Deep learning prediction of pathological complete response in breast cancer using Mamba architecture

Abstract Deep learning is capable of efficiently predicting the therapeutic efficacy of neoadjuvant chemotherapy (NAC) in breast cancer. However, current methods predominantly rely on convolutional neural networks or transformer architectur...

Datasets describing hydrogel properties and cellular metrics for modeling of tumor dormancy

Breast cancer dormancy is an underlying challenge toward targeting and controlling metastatic recurrence and disease progression. Development of engineered, well-defined in vitro models is necessary to systematically recapitulate tumor dorm...

A genome-wide association study on meat consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort study

Recent genome-wide association studies (GWAS) on the dietary habits of the Japanese population have shown that an effect rs671 allele was inversely associated with fish consumption, whereas it was directly associated with coffee consumption...

Data on the cytotoxicity of chlorogenic acid in 3D cultures of HT-29 cells

Functional foods, beyond basic nutrition, offer health benefits to consumers thanks to the presence of bioactive compounds such as some phytochemicals [1,2]. Today, these foods are of particular interest in biomedical research due to their ...

A Focus on Simulation in Medical Informatics

This special issue of JAMIA addresses simulation, a methodology that holds great promise for the advancement of information technology in health care. Simulation has been termed a third domain, complementing both natural language and mathem...

plsMD: a plasmid reconstruction tool from short-read assemblies

Abstract Background While whole genome sequencing has become a cornerstone of antimicrobial resistance surveillance, the reconstruction of plasmid sequences from short-read data remains a challenge due to repetitive sequences and assembly f...

Evaluation of the Quality of Life in Adult Cancer Survivors (QLACS) scale for long-term cancer survivors in a sample of breast cancer survivors

Abstract Background This paper evaluates psychometric properties of a recently developed measure focusing on the health-related quality of life (HRQL) of long-term cancer survivors, the Quality of Life in Adult Survivors scale (QLACS), in a...

Percutaneous CT-Guided Bone Lesion Biopsy for Confirmation of Bone Metastases in Patients with Breast Cancer

We aimed to determine diagnostic accuracy of CT-guided bone lesion biopsy for the confirmation of bone metastases in patients with breast cancer and assessment of hormone receptor status in metastatic tissue. A total of 56 female patients w...

Is a prostate cancer screening anxiety measure invariant across two different samples of age-appropriate men?

Abstract Background In order to explore the influence of anxiety on decision–making processes, valid anxiety measures are needed. We evaluated a prostate cancer screening (PCS) anxiety scale that measures anxiety related to the prostate–spe...

Corrigendum: Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer

Research in medical informatics

Medical informatics is concerned with the application of computers in the medical and biological sciences and has been considered a field of research in its own right for more than twenty years. In Malaysia, however, there are very few publ...

Non-parametric synergy modeling of chemical compounds with Gaussian processes

Abstract Background Understanding the synergetic and antagonistic effects of combinations of drugs and toxins is vital for many applications, including treatment of multifactorial diseases and ecotoxicological monitoring. Synergy is usually...

Data describing the poor outcome associated with a breast cancer diagnosis in the post-weaning period

Postpartum breast cancer (PPBC) - which according to new data, can extend to 5–10 years after the birth - are estimated to represent 35–55% of all cases of breast cancer in women younger than 45 years. Increasing clinical evidence indicates...

Infodemiological data concerning silicosis in the USA in the period 2004–2010 correlating with real-world statistical data

This article reports data concerning silicosis-related web-activities using Google Trends (GT) capturing the Internet behavior in the USA for the period 2004–2010. GT-generated data were then compared with the most recent available epidemio...

A Collaborative Approach to Improving Breast Cancer Screening and Follow-Up Through Multicomponent Interventions and Process Improvements: The Links to Care Community Grants Project study protocol and baseline findings

Background: The Links to Care Community Grants Project was developed to improve breast cancer outcomes by increasing access to appropriate follow-up care, improving processes for care transitions, and enhancing care coordination between com...

Medical Imaging Informatics and Medical Informatics: Opportunities and Constraints

OBJECTIVES: The Yearbook of Medical Informatics is published annually by the International Medical Informatics Association (IMIA) and contains a selection of recent excellent papers on medical informatics research (http://www.yearbook.uni-h...

Changes in physical activity and sedentary behavior during the first COVID-19 pandemic- restrictions in Germany: a nationwide survey

Abstract Background The COVID-19 pandemic restrictions posed challenges to maintaining healthy lifestyles and physical well-being. During the first mobility restrictions from March to mid-July 2020, the German population was advised to stay...

Understanding Public Perceptions of Lung Cancer in China: Infodemiology Study of Baidu Index and Weibo Posts

Abstract BackgroundIn China, lung cancer remains a major public health concern and accounts for a substantial proportion of cancer-related deaths nationwide. However, limited research has examined public perceptions of lung canc...