Academic Articles & Research Papers

Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern

Glycosylation of the SARS-CoV-2 spike (S) protein represents a key target for viral evolution because it affects both viral evasion and fitness. Successful variations in the glycan shield are difficult to achieve though, as protein glycosyl...

Preclinical ex-vivo Testing of Anti-inflammatory Drugs in a Bovine Intervertebral Degenerative Disc Model

Discogenic low back pain (LBP) is a main cause of disability and inflammation is presumed to be a major driver of symptomatic intervertebral disc degeneration (IDD). Anti-inflammatory agents are currently under investigation as they demonst...

Genetic Manipulation of Plants: A More-than-Human Ethical Challenge

The central argument of this article is that the genetic manipulation of plants raises profound ethical questions that cannot be adequately addressed within a purely anthropocentric framework. Drawing on Hans Jonas’s philosophy of responsib...

The Effect of Health Literacy on a Brief Intervention to Improve Advance Directive Completion: A Randomized Controlled Study

Objective Completion of an advance directive (AD) document is one component of advanced care planning. We evaluated a brief intervention to enhance AD completion and assess whether the intervention effect varied according to health literacy...

Gestão do trabalho, da educação, da informação e comunicação na atenção básica à saúde de municípios das regiões Sul e Nordeste do Brasil Management of work, education, information, and communication in primary healthcare in cities in Southern and Northeastern Brazil

A descentralização das ações no Sistema Único de Saúde requer competências específicas para a gestão municipal. As demandas incluem o gerenciamento de equipes de trabalho, estrutura física e tecnológica, e organização de insumos e estratégi...

Patient perception of pain care in hospitals in the United States

Anita Gupta1, Sarah Daigle2, Jeffrey Mojica3, Robert W Hurley41Pain Management Division, Department of Anesthesiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; 2Department of Anesthesiology and Critical Care, 3D...

Evaluasi Penggunaan Aplikasi Sistem Keuangan Desa (Siskeudes) di Nagari Kayu Tanam Kecamatan 2x11 Kayutanam

Aplikasi Siskeudes ini merupakan suatu sistem yang dikembangkan oleh BPKP dalam meningkatkan kualitas tata kelola keuangan desa. Pemerintah Padang Pariaman sudah menetapkan Siskeudes untuk diaplikasikan namun pada kenyataannya masih banyak ...

Early virtual reality adopters in Spain: sociodemographic profile and interest in the use of virtual reality as a learning tool

This study describes the social and demographic profile of the first generation of users of marketed virtual reality (VR) viewers in Spain and, subsequently, it assesses the interest in its use as a learning tool. For that purpose, an onlin...

An Investigation of Disk Thickness in M51 from Hα, Paα, and Mid-infrared Power Spectra

Power spectra (PS) of high-resolution images of M51 (NGC 5194) taken with the Hubble Space Telescope and the James Webb Space Telescope (JWST) have been examined for evidence of disk thickness in the form of a change in slope between large ...

Nuclear structure and astrophysics

The nuclear structure in regions of the Segré chart which are of astrophysical importance is reviewed. The main emphasis is put on those nuclei that are relevant for stellar nucleosynthesis in fusion processes, and in slow neutron capture, ...

Erratum to: Search for resonant and nonresonant production of pairs of dijet resonances in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV

eLISA: Astrophysics and cosmology in the millihertz regime

This document introduces the exciting and fundamentally new science and astronomy that the European New Gravitational Wave Observatory (NGO) mission (derived from the previous LISA proposal) will deliver. The mission (which we will refer to...

A search for $t\bar{t}$ resonances with the ATLAS detector in 2.05 fb−1 of proton-proton collisions at $\sqrt{s} = 7~\mathrm{TeV}$

Abstract A search for top quark pair resonances in final states containing at least one electron or muon has been performed with the ATLAS experiment at the CERN Large Hadron Collider. The search uses a data sample corresponding to an integ...

Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study [version 3; peer review: 2 approved, 1 approved with reservations]

Background High quality shared decision-making (SDM) conversations involve people with or at risk of osteoporosis and clinicians working together to decide, where appropriate, which evidence-based medicines best fit the person’s life, belie...

Plasma Exchange for ANCA-Associated Vasculitis: An International Survey of Patient PreferencesPlain Language Summary

Rationale & Objective: We sought to elicit patient preferences regarding the use of plasma exchange in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and its tradeoffs of risk of kidney failure and risk of serious infec...

Epidemiology: Beyond the Basics

Epidemiology: Beyond the BasicsAuthors: SZKLO, Moyses, MD, DrPH (Johns Hopkins Univ.); NIETO, F. Javier, MD, PhD (Johns Hopkins Univ.) Bibliographic Data: (ISBN: 0–8342-0618–8, Aspen Publishers, Inc., 2000, $55.00) 495 pages, soft cover Aud...

Epidemiology of Gallstones

Transcatheter heart valve interventions for patients with rheumatic heart disease

Rheumatic heart disease [RHD] is the most prevalent cause of valvular heart disease in the world, outstripping degenerative aortic stenosis numbers fourfold. Despite this, global resources are firmly aimed at improving the management of deg...

Combined Letrozole and Growth Hormone Therapy in Late-Pubertal Males with Advanced Bone Age and Open Knee Physes

Background/Objectives: The therapeutic window for growth hormone (GH) therapy in late-pubertal males with advanced bone age (BA ≥ 15 years) is generally considered closed. Yet, open knee physes may indicate residual growth potential. This s...

Epidemiology of Alzheimer's Disease

Monique M. B. Breteler, Jules J. Claus, Cornelia M. van Duijn, Lenore J. Launer, Albert Hofman; Epidemiology of Alzheimer's Disease, Epidemiologic Reviews, Volu...