Academic Articles & Research Papers

A Diagnostic Algorithm Based on Urine Antigen and Blood Polymerase Chain Reaction Testing for Visceral Leishmaniasis in HIV-Coinfected Patients in Northwest Ethiopia.

From Isolation to Application: Utilising Phage‐Antibiotic Synergy in Murine Bacteremia Model to Combat Multidrug‐Resistant Enterococcus faecalis

ABSTRACT Enterococcus species, natural inhabitants of the human gut, have become major causes of life‐threatening bloodstream infections (BSIs) and the third most frequent cause of hospital‐acquired bacteremia. The rise of high‐level gentam...

Characterization of Primate Antibody Responses to Administered Murine Monoclonal Immunoglobulin

Murine monoclonal antibodies (MAb) are currently being assessed for their utility as tools in cancer management. Anti-murine immunoglobulin responses have been observed in many patients receiving monoclonal antibody treatment. In this study...

The Advances of Single-Cell RNA-Seq in Kidney Immunology

Kidney diseases are highly prevalent and treatment is costly. Immune cells play important roles in kidney diseases; however, it has been challenging to investigate the contribution of each cell type in kidney pathophysiology. Recently, the ...

Construction of the cancer patients’ database based on the US National Health and Nutrition Examination Survey (NHANES) datasets for cancer epidemiology research

Abstract Background The US National Health and Nutrition Examination Survey (NHANES) dataset does not include a specific question or laboratory test to confirm a history of cancer diagnosis. However, if straightforward variables for cancer ...

PRIMUS: Comprehensive proteomics of mouse intervertebral discs that inform novel biology and relevance to human disease modelling

Mice are commonly used to study intervertebral disc (IVD) biology and related diseases such as IVD degeneration. Discs from both the lumbar and tail regions are used. However, little is known about compartmental characteristics in the diffe...

Piezo1 knockdown activates PI3K/AKT and enhances SPP1 to drive M2 macrophage polarization and reduce cardiac inflammation

Abstract Piezo1 plays a key role in the immune response during sepsis. To date, our understanding of the role of Piezo1 in inflammatory diseases has mostly been limited to influencing vasomotor function and regulating inflammatory infiltrat...

The Genetic Architecture of Murine Glutathione Transferases.

Glutathione S-transferase (GST) genes play a protective role against oxidative stress and may influence disease risk and drug pharmacokinetics. In this study, massive multiscalar trait profiling across a large population of mice derived fro...

Haploidentical and MHC-identical cells exhibit broadly similar immune reconstitution kinetics, with some compartment-specific differences, following hematopoietic cell transplantation in a murine model of severe combined immunodeficiency.

DUCK-Net: automated deep learning segmentation of ductular reactions in murine liver injury captures multicellular niche dynamics from H&E morphology.

Amplified MS2 labeling reveals heterogeneous dynamics of RNA granules in the live murine brain ex vivo.

Identification of immune-associated biomarkers of diabetes nephropathy tubulointerstitial injury based on machine learning: a bioinformatics multi-chip integrated analysis

Abstract Background Diabetic nephropathy (DN) is a major microvascular complication of diabetes and has become the leading cause of end-stage renal disease worldwide. A considerable number of DN patients have experienced irreversible end-st...

Machine learning-based diagnostic prediction of minimal change disease: model development study

Abstract Minimal change disease (MCD) is a common cause of nephrotic syndrome. Due to its rapid progression, early detection is essential; however, definitive diagnosis requires invasive kidney biopsy. This study aims to develop non-invasiv...

Association between phthalate exposure and accelerated bone maturation in Chinese girls with early puberty onset: a propensity score-matched case–control analysis

Abstract Estrogen can promote the acceleration of bone maturation and phthalate esters (PAEs) have estrogen-mimicking effects. We investigated whether PAEs are associated with the acceleration of bone age (BA) in girls with early onset of p...