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Anticancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) capped silver and zinc oxide nanoparticles and its molecular characterization

Zabin K. Bagewadi, Gouri H. Illanad, T. M. Yunus Khan, Shaik Mohamed Shamsudeen et al. • Bioresources and Bioprocessing (2025)

Abstract The current investigation reports anti-cancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) and L-Glutaminase capped nanoparticles. The highest L-Glutaminase production of 9.57 U/mL w...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40643-025-00857-w

Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival

Noela Rodriguez-Losada, Noela Rodriguez-Losada, Rune Wendelbob, M. Carmen Ocaña et al. • Frontiers in Neuroscience (2020)

Emerging scaffold structures made of carbon nanomaterials, such as graphene oxide (GO) have shown efficient bioconjugation with common biomolecules. Previous studies described that GO promotes the differentiation of neural stem cells and ma...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2020.570409

Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity

Dipsikha Biswas, Logan Slade, Luke Duffley, Neil Mueller et al. • Cell Death Discovery (2021)

Proposed mechanism. A Doxorubicin (DOX) targets the BCAA catabolic pathway in TNBCs, by downregulating BCKDK and augmenting clearance of intracellular BCKAs. B Genetic or pharmacological (high BT2 concentration) inhibition of BCKDK results ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41420-021-00602-0

Application of a novel pH-responsive gemini surfactant for delivery of curcumin molecules

Maral Rahimzadeh, Majid Sadeghizadeh, Farhood Najafi, Seyed Shahriar Arab et al. • Materials Research Express (2020)

During the last few decades, extensive studies have been conducted to elucidate the anti-cancer effects of curcumin. Despite promising results indicating curcumin could impede cancer cells ability thrive and proliferation, clinical applicat...

DOAJ Open Access (DOAJ) DOI: 10.1088/2053-1591/ab770f

Structural Design, Synthesis and Antioxidant, Antileishmania, Anti-Inflammatory and Anticancer Activities of a Novel Quercetin Acetylated Derivative

Saul Vislei Simões da Silva, Orlando Maia Barboza, Jéssica Teles Souza, Érica Novaes Soares et al. • Molecules (2021)

Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological use. The aim of this study was to perform structural mod...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules26226923

Acute exposure to copper oxide nanoparticles impairs testicular function and sperm quality in adult male albino rats

Lamiaa Hassan, Ibrahem M. A. Hasan, Zeinab Al-Amgad, Hassan Ahmed • SVU-International Journal of Veterinary Sciences (2024)

Copper oxide nanoparticles (CuO NPs) are metallic nanoparticles fulfilling several functions such as good conductivity, catalyst, used in sensors and energy storage devices, and antibacterial characteristics. However, the cytotoxicity and...

DOAJ Open Access (DOAJ) DOI: 10.21608/SVU.2023.226884.1288

The Role of Bone Marrow-Derived Mesenchymal Stromal Cells and Hesperidin in Ameliorating Nephrotoxicity Induced by Cisplatin in Male Wistar Rats

Khalid Mohamed Mazher, Osama Mohamed Ahmed, Hadeer Abdallah Sayed, Taghreed Mohamed Nabil • International Journal of Molecular and Cellular Medicine (2021)

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) and antioxidants opened the way for many effective therapeutic experiments against damaged organs like kidneys. Nephrotoxicity is the main complication of chemotherapeutic drugs. There...

DOAJ Open Access (DOAJ)

Efficient electrochemical determination of dopamine in the presence of uric acid in real samples using tungsten disulfide nanostructure modified electrode

Ibrahim Ayad Jihad, Thekrayat Joodi Jassim, Zainab Naeif Mageed • ADMET and DMPK (2025)

Background and purpose: Research on the detection of uric acid (URA) and dopamine (DPA) is ongoing because of the difficulties posed by their closely overlapping oxidation potentials. Tungsten disulfide nanostructures have become attractive...

DOAJ Open Access (DOAJ) DOI: 10.5599/admet.2968

EFFECT OF VITAMIN A ON CYCLOSPORINE NEPHROTOXICITY IN UNINEPHRECTOMIZED RATS

Hoda Mohamed, Hazar Yacoub, Heba Ameen, Dureah Sebah • Zagazig Journal of Pharmaceutical Sciences (1997)

The influence of vitamin A (1.5 mg kg-1 body weight) administration for two weeks on cyclosporine A (CsA, 25 mg kg-1 body weight) induced renal dysfunction has been investigated in uninephrectomized and sham nephrectomized rats. Single kidn...

DOAJ Open Access (DOAJ) DOI: https://doi.org/10.21608/zjps.1997.184951

Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-κB Signaling Cascades

Xinpeng Jiang, Shanshan Gu, Di Liu, Lili Zhao et al. • Frontiers in Microbiology (2018)

Aims:Lactobacillus strains have protective effects against heavy metals while relieving oxidative stress and modulating the immune response. Mechanisms that ameliorate heavy metal toxicity and the relationship between probiotics and gut bar...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2018.02425

Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells

Yuki Ota, Takuya Kawanai, Ryo Watanabe, Akira Nishimura et al. • Journal of Pharmacological Sciences (2013)

Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicit...

DOAJ Open Access (DOAJ) DOI: 10.1254/jphs.13012SC

Modified Riceberry rice extract suppresses melanogenesis-associated cell differentiation through tyrosinase-mediated MITF downregulation on B16 cells and in vivo zebrafish embryos

Teerapat Rodboon, Sasithorn Sirilun, Seiji Okada, Ryusho Kariya et al. • Research in Pharmaceutical Sciences (2020)

Background and purpose: Excessive melanin production caused by overactive tyrosinase (TYR) enzyme results in several dermatological problems. The TYR inhibitor, derived from metabolite changes during fermentation, has been well recognized f...

DOAJ Open Access (DOAJ) DOI: 10.4103/1735-5362.297852

Essential Oils from Artemisia herba alba Asso., Maticaria Recutita L., and Dittrichia Viscosa L. (Asteraceae): A Promising Source of Eco-Friendly Agents to Control Callosobruchus maculatus Fab. Warehouse Pest

Allali Aimad, Mohammed Bourhia, Hadin Hana, Rezouki Sanae et al. • Journal of Chemistry (2022)

Callosobruchus maculatus (Fab.) (C. maculatus) is one of the major pests of legume seeds in storage causing significant damage, leading to food insecurity and low income for farmers. This work was planned to develop eco-friendly agents from...

DOAJ Open Access (DOAJ) DOI: 10.1155/2022/2373460

Comparative Evaluation of the Antioxidant and Immunomodulatory Activities of Carrot (<i>Daucus carota</i> L.) Aerial Parts and Roots Using Different Extraction Methods

Sung-Sook Choi, Jae-Eun Lee, Hyo-Jun Lee, Kyung-Ae Lee • Foods (2025)

Carrot (Daucus carota L.) is a widely consumed root vegetable, yet its aerial parts, including leaves and stems, are typically discarded as agricultural by-products, despite their potential biological value. This study comparatively evaluat...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14233993

Engaging Nurses in Effective Cost of Care Conversations to Address Cancer-Related Financial Toxicity: Results from an Exploratory Survey

Jean S. Edward, Amanda Thaxton Wiggins, Louis G. Baser, Haafsah Fariduddin et al. • Current Oncology (2025)

Few evidence-based trainings exist on how to equip healthcare providers, particularly nurses, with the skills to engage in cost of care conversations with patients/caregivers to mitigate the impact of cancer-related financial toxicity. This...

DOAJ Open Access (DOAJ) DOI: 10.3390/curroncol32010033

Masterbatch-enabled acceleration of polyolefin biodegradation under open air terrestrial environmental conditions

Ceren Kütahya, Catalina Cruañas Pániker, Faith Ly, Arjun Jerath et al. • npj Materials Degradation (2026)

Abstract Polyolefins, commonly used in packaging and single-use products, are notoriously persistent in the environment, contributing significantly to environmental pollution. In scientific literature to date, polyolefins have not been repo...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41529-026-00817-5

Toxicity and biodistribution comparison of functionalized nanodiamonds, quantum dot nanocarbons and gold nanoparticles

Elena Alexander, Kam W. Leong • Frontiers in Nanotechnology (2025)

IntroductionNanomaterials are extensively utilized in applications ranging from electronics to biomedical therapies; however, their widespread use has prompted concerns about potential toxicity in humans. Understanding the biodistribution a...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnano.2025.1512622

Smart integrated nanosystems for biomedical applications:critical issues and perspectives

Domenico Lombardo, Luigi Pasqua, Mikhail A. Kiselev • Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali (2019)

During the last decades the progresses of nanoscience and nanotechnology for biomedical application stimulated the transition from traditional drug delivery systems to the development of smart integrated nanosystems with stimuli-responsive ...

DOAJ Open Access (DOAJ) DOI: 10.1478/AAPP.97S2A14

Chitosan nanoparticles as next-generation carriers for veterinary DNA vaccines: Mechanisms, immune responses, and translational prospects

Miguel González-Lozano, José Alberto Cano-Buendía • Veterinary World (2025)

Background and Aim: Chitosan-based DNA nanoparticles have emerged as a promising next-generation platform for veterinary vaccines, addressing several limitations of conventional attenuated, inactivated, and recombinant formulations. Chitosa...

DOAJ Open Access (DOAJ) DOI: 10.14202/vetworld.2025.3826-3838