Academic Articles & Research Papers

The Effect of In Vitro Digestion on Polyphenolic Compounds and Antioxidant Properties of Sorghum (<i>Sorghum bicolor</i> (L.) Moench) and Sorghum-Enriched Pasta

The phenol content of sorghum is a unique feature among all cereal grains; hence this fact merits the special attention of scientists. It should be remembered that before polyphenols can be used in the body, they are modified within the dig...

Effects of Luteolin on Human Breast Cancer Using Gene Expression Array: Inferring Novel Genes

Taraxacum officinale (dandelion) is often used in traditional Chinese medicine for the treatment of cancer; however, the downstream regulatory genes and signaling pathways mediating its effects on breast cancer remain unclear. The present s...

Molecular docking and mouse modeling suggest CMKLR1 and INSR as targets for improving PCOS phenotypes by minocycline

Polycystic ovary syndrome (PCOS) is the most common cause of women’s infertility. Some inflammatory pathways play a pivotal role in the pathogenesis of PCOS. This study aimed to investigate the possible beneficial effects of minocycline on ...

Barriers and opportunities for clinical trials in Bahrain: a qualitative study of key opinion leaders

Background and objectives Clinical trials are essential for advancing scientific knowledge and improving patient outcomes. In the last decade, Bahrain has made notable progress in healthcare. However, clinical trial participation from the r...

Timing of menarche and pubertal growth patterns using the QEPS growth model

ObjectivesTo explore the timing of menarche, postmenarcheal growth, and to investigate the impact of various variables on menarcheal age and postmenarcheal and pubertal growth.Study DesignThis longitudinal community population-based study a...

Assessment of knowledge, attitude, and practices regarding the relationship of obesity with diabetes among the general community of Pakistan

This study sought to evaluate the influence of knowledge, attitude, and practices assessment on diabetes related to obesity in Pakistani society. Data was collected both through door to door and online survey approaches from 518 participant...

Prevalence of Congenital Anomalies in the Northwest of Iran

Background and Objectives Every year, about three hundred thousands of infant deaths occur because of congenital anomalies. Some continue to live with various types of disabilities. Low and middle income countries have higher rate of congen...

Protocol to measure human IL-6 secretion from CAR T cell-primed macrophage and monocyte lineage cells in vitro and in vivo using humanized mice

Summary: Chimeric antigen receptor (CAR) T cell therapy often causes serious toxicities, such as cytokine release syndrome (CRS), mainly due to interleukin-6 (IL-6) secreted by monocyte lineage cells. Here, we describe a protocol to generat...

Obstetric complications in children with Attention Deficit/Hyperactivity Disorder and Learning Disability

This study aims to determine whether children with ADHD and learning disabilities (LD) have a significant history of obstetrical complications when compared to children with ADHD but without LD. Methods: Sixty-four children aged 6 to 12 yea...

Psychological STress, Anxiety, and Depression After miscarriage in comparison to successful pregnancy and abortion: design and protocol for the observational cohort study STRADA

Introduction Miscarriage occurs in 15%–20% of clinically recognised pregnancies. It may cause acute or prolonged psychological distress such as anxiety, depression and post-traumatic stress disorder (PTSD). Data on symptom severity and dura...

Association between maternal plasma glucose levels during pregnancy and risk of preterm birth: a retrospective study

Abstract Background Preterm birth is a leading cause of health problems and death in infants. This study aims to investigate the association between maternal plasma glucose levels during pregnancy and risk of preterm birth. Methods This pop...

Developing a nomogram to predict recurrent intussusception after pneumatic reduction of primary intussusception in children

Abstract Backgroud Intussusception is a common acute abdominal disease in children, often leading to acute ileus in infants and young children. Objective This study aimed to develop and validate a nomogram for predicting recurrent intussusc...

Preoperative and intraoperative assessment of myometrial invasion in patients with FIGO stage I non-endometrioid endometrial carcinoma—a large-scale, multi-center, and retrospective study

Abstract Introduction Myometrial invasion is a prognostic factor for lymph node metastases and decreased survival in non-endometrioid endometrial carcinoma patients. Herein, we explored the mode of myometrial invasion diagnosis in FIGO stag...

Pathway analysis of the impact of family function and self-efficacy on depression and anxiety in patients undergoing in vitro fertilization-embryo transfer

Abstract Background Patients undergoing assisted reproductive technology (ART) experience significant psychological distress due to infertility, with depression and anxiety being the most common manifestations. This study investigates the i...

Barriers and facilitators of retention in care after cervical cancer screening: patients’ and healthcare providers’ perspectives

Abstract Background Cervical cancer continues to threaten women’s health, especially in low-resource settings. Regular follow-up after screening and treatment is an effective strategy for monitoring treatment outcomes. Consequently, underst...

Analysis of TORCH screening and prenatal risk assessment for childbearing-age women in different regions of China

Abstract Objective By conducting TORCH screening and risk assessment analysis on childbearing-age women in different regions of China, the aim is to provide reference for reducing adverse pregnancy outcomes and improving the health status o...

Predictive Value of Serum Cytokeratin 19 Level for the Feasibility of Conserving Ovaries in Endometrial Cancer

Objective: To determine the predictive value of cytokeratin 19 (CK19) for evaluating the safety of ovarian preservation in patients with endometrial cancer (EC).Methods: Five hundred and seventeen EC patients hospitalized from November 2010...

Hypermethylated PCDHGB7 as a universal cancer only marker and its application in early cervical cancer screening

Performance of computational algorithms to deconvolve heterogeneous bulk ovarian tumor tissue depends on experimental factors

Abstract Background Single-cell gene expression profiling provides unique opportunities to understand tumor heterogeneity and the tumor microenvironment. Because of cost and feasibility, profiling bulk tumors remains the primary population-...

The History and New Trends of Medical Informatics

ABSTRACT The breakthrough of the computer and information technologies in all the segments of the society, led to the needs for the computer and information technologies. The knowledge of information technology is now part of general litera...