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Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of diabetic kidney disease (DKD)

Zhi Zheng, Yunkuo Li, Yujie Pan • Cell Death Discovery (2026)

Abstract Diabetic kidney disease (DKD), a prevalent microvascular complication of diabetes, is a leading cause of chronic kidney disease and end-stage renal disease. Moreover, it plays a crucial role in the morbidity and mortality of diabet...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41420-026-03117-8

Widespread geographic distribution of filarioid nematodes in caribou (Rangifer tarandus sspp.) in Canada

Aparna Mariyam Thomas, Guilherme G. Verocai, John Soghigian, Fabien Mavrot et al. • International Journal for Parasitology: Parasites and Wildlife (2025)

The caribou (Rangifer tarandus sspp.) is a keystone wildlife species in northern ecosystems that plays a central role in the culture, spirituality and food security of Indigenous People. The Arctic is currently experiencing an unprecedented...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ijppaw.2024.101030

Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety

Zhiyi Chen, Yancheng Tang, Xuerong Liu, Wei Li et al. • Nature Communications (2024)

Abstract Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological in...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-024-55008-0

Sequential Portal Vein Embolization and Percutaneous Radiofrequency Ablation for Future Liver Remnant Growth: A Minimally Invasive Alternative to ALPPS Stage-1 in Treatment of Hepatocellular Carcinoma

Qiang Wang, Qiang Wang, Yujun Ji, Torkel B. Brismar et al. • Frontiers in Surgery (2021)

Background: To evaluate the feasibility and efficacy of sequential portal vein embolization (PVE) and radiofrequency ablation (RFA) (PVE+RFA) as a minimally invasive variant for associating liver partition and portal vein ligation for stage...

DOAJ Open Access (DOAJ) DOI: 10.3389/fsurg.2021.741352

Review on: Women with Polycystic Ovary Syndrome

Neelam Gusain, Ashish P. Anjankar, Ranjit S. Ambad, Roshan K. Jha et al. • Journal of Pharmacy and Bioallied Sciences (2025)

One of the biggest health issues facing women in their childbearing years worldwide is polycystic ovarian syndrome, or PCOS. PCOS is a prevalent endocrine condition with well-known negative effects on metabolism, reproduction, and cardiovas...

DOAJ Open Access (DOAJ) DOI: 10.4103/jpbs.jpbs_1995_24

Evaluating key predictors of breast cancer through survival: a comparison of AFT frailty models with LASSO, ridge, and elastic net regularization

Senyefia Bosson-Amedenu, Emmanuel Ayitey, Francis Ayiah-Mensah, Luyton Asare • BMC Cancer (2025)

Abstract Background Frailty models are extensively utilized in survival analysis to address unobserved heterogeneity among individuals. However, selecting the most robust model for survival prediction, especially in the context of high-dime...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12885-025-14040-z

Mathematical Modeling of Leptospirosis With Misdiagnosis

Japheth Musingila Mwongela, Caroline Kanyiri, Virginia Kitetu • Journal of Applied Mathematics (2026)

Leptospirosis is a widespread zoonotic bacterial disease that continues to pose a major public health challenge, particularly in developing countries where it causes substantial morbidity, mortality, and economic losses. A key problem in co...

DOAJ Open Access (DOAJ) DOI: 10.1155/jama/5513951

Estimating the number of cardio-pulmonary events potentially averted by fine particulate matter air quality index activity guidelines

Robert D Brook, Pia-Allison Roa, Phillip D Levy, Samantha J Bauer et al. • American Journal of Preventive Cardiology (2025)

Background: Fine particulate matter 100 for PM2.5) for 3 groups (healthy adults, ASCVD and pulmonary disease patients) in the US during 2022. The theoretical number of adverse events potentially prevented per county was estimated each day a...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ajpc.2025.101266

Detection of Toxoplasmosis in Association with Autoimmune Thyroid Disease During Pregnancy in Duhok, Iraq

Manal Adil Murad, Souzan Hussain Eassa • Journal of Pure and Applied Microbiology (2023)

Toxoplasma gondii is a protozoan parasite that is widely distributed in the human population and is responsible for corresponding global morbidity. Specifically, T. gondii causes toxoplasmosis, leading to miscarriage, stillbirth, and neural...

DOAJ Open Access (DOAJ) DOI: https://doi.org/10.22207/JPAM.17.2.05

Investigations of the impact of polluted natural waters on cardiovascular diseases and development of integrated prevention system

Vyacheslav Vishnevetskiy, Vladislav Popruzhniy • Przegląd Naukowy Inżynieria i Kształtowanie Środowiska (2019)

The aim of this study was to establish the correlation between natural water pollutions and the prevalence of heart diseases. We analyzed the data from the 2014 Federal Service Report on the state of sanitary and epidemiological welfare of ...

DOAJ Open Access (DOAJ) DOI: 10.22630/PNIKS.2019.28.1.5

Neurodevelopmental Disorders Comorbid with Deafness in Children: A Systematic Review of Previous Studies

Fatemeh Nikkhoo, asgar chubdari • Ravānshināsī-i Afrād-i Istis̠nāyī (2020)

The comorbidity of neurodevelopmental disorders regarding deafness has been confirmed in several studies, which further emphasizes the necessity of paying more attention to diagnostic and rehabilitation approaches in this field. The primary...

DOAJ Open Access (DOAJ) DOI: 10.22054/jpe.2021.55757.2226

Perspective on the Therapeutics of Anti-Snake Venom

Isabel Gómez-Betancur, Vedanjali Gogineni, Andrea Salazar-Ospina, Francisco León • Molecules (2019)

Snakebite envenomation is a life-threatening disease that was recently re-included as a neglected tropical disease (NTD), affecting millions of people in tropical and subtropical areas of the world. Improvement in the therapeutic approaches...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules24183276

Indagine epidemiologica locale dell’eziologia delle infezioni delle vie urinarie (IVU) nosocomiali e comunitarie e dell’antibiotico-sensibilità degli uropatogeni.

Agostina Ronca, Sabrina Brenci, Luisa Santoriello, Anna Marchese et al. • Microbiologia Medica (2007)

Background: Urinary tract infections (UTIs) are common infectious diseases that can be associated with substantial morbidity. During the last decade, resistance to ampicillin and co-trimoxazole has increased in Escherichia coli, the most co...

DOAJ Open Access (DOAJ) DOI: 10.4081/mm.2007.2603

Applying the lessons of maternal mortality reduction to global emergency health

Emilie J Calvello, Alexander P Skog, Andrea G Tenner, Lee A Wallis • Bulletin of the World Health Organization (2015)

Abstract Over the last few decades, maternal health has been a major focus of the international community and this has resulted in a substantial decrease in maternal mortality globally. Although, compared with maternal illness, medical and ...

DOAJ Open Access (DOAJ) DOI: 10.2471/BLT.14.146571

Clinical Features of CINin ChineseVery Elderly Patients Undergoing Coronary Angiography Procedure With Hydration Treatment: A Three-Center, Prospective Study

Liwen Bao, Jun Bo, Bo Jin, Nanqing Xiong et al. • International Journal of Gerontology (2018)

Summary: Background: To assess the morbidity and risk factors of contrast induced nephropathy (CIN) in Chinese very elderly patients. Methods: The very elderly patients whose age ≥75 year-old, from North Huashan Hospital, South Renji Hospi...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ijge.2018.05.010

Revisiting Mobility Limitations of Seniors in Singapore, 1995 to 2011

Soon-Hock Kang Phd, Vanessa Yong PhD, Angelique Chan PhD, Yasuhiko Saito PhD • Gerontology and Geriatric Medicine (2016)

Singapore’s life expectancy at birth and at age 65 continues to improve. Although this is a positive development, it is necessary to understand how much of this increased life expectancy is spent with and without mobility limitations. This ...

DOAJ Open Access (DOAJ) DOI: 10.1177/2333721416645034

Local, collaborative, stepped, and personalized care management for older people with chronic diseases – results from the randomized controlled LoChro-trial

Gloria Metzner, Lukas Maximilian Horstmeier, Jürgen Bengel, Eva Maria Bitzer et al. • BMC Geriatrics (2023)

Abstract Background In the aging population of Western societies, an increasing number of older adults have multiple chronic diseases. As multifaceted health problems imply the involvement of several healthcare professionals, multimorbid ol...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-023-03797-2

Nutritional status, literacy, and risk factors of malnutrition in the population over 50 years of age - findings from the SHARE project

Tereza Vágnerová, Olga Dvořáčková, Eva Topinková • Clinical Nutrition Open Science (2024)

Summary: Background & Aims: The transition from middle age to old age (from adults aged 50–55 years to older seniors aged 75–80 years) represents a critical period in terms of changes in body composition, i.e., increase in body fat per...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nutos.2024.01.006

TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease

Eva Steinke, Eva Steinke, Eva Steinke, Olaf Sommerburg et al. • Frontiers in Medicine (2023)

BackgroundLung disease as major cause for morbidity in patients with cystic fibrosis (CF) starts early in life. Its large phenotypic heterogeneity is partially explained by the genotype but other contributing factors are not well delineated...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.1034290