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Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Yujing Huang, Xiaohan Guo, Yi Wu, Xingyu Chen et al. • Signal Transduction and Targeted Therapy (2024)

Abstract Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergenc...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41392-024-01745-z

Nanotechnology

Matthew P. Sullivan, Kevin Jude McHale, Javad Parvizi, Samir D. Mehta • The Bone & Joint Journal (2014)

Nanotechnology is the study, production and controlled manipulation of materials with a grain size < 100 nm. At this level, the laws of classical mechanics fall away and those of quantum mechanics take over, resulting in unique behaviour of...

OPENALEX DOI: https://doi.org/10.1302/0301-620x.96b5.33606

Emerging nanomaterials for novel wound dressings: From metallic nanoparticles and MXene nanosheets to metal-organic frameworks

Gholamreza Faghani, Amir Azarniya • Heliyon (2024)

The growing need for developing reliable and efficient wound dressings has led to recent progress in designing novel materials and formulations for different kinds of wounds caused by traumas, burns, surgeries, and diabetes. In cases of ext...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2024.e39611

Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of diabetic kidney disease (DKD)

Zhi Zheng, Yunkuo Li, Yujie Pan • Cell Death Discovery (2026)

Abstract Diabetic kidney disease (DKD), a prevalent microvascular complication of diabetes, is a leading cause of chronic kidney disease and end-stage renal disease. Moreover, it plays a crucial role in the morbidity and mortality of diabet...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41420-026-03117-8

Therapeutic potential of hyaluronic acid hydrogel combined with bone marrow stem cells-conditioned medium on arthritic rats’ TMJs

Mai M. Assi, Mohammed E. Grawish, Heba Mahmoud Elsabaa, Mohamad E. Helal et al. • Scientific Reports (2024)

Abstract Conditioned media (CM) is derived from mesenchymal stem cells (MSC) culture and contains biologically active components. CM is easy to handle and reduces inflammation while repairing injured joints. Combination therapy of the CM wi...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-024-77325-6

Laterally positioned flap-revised technique along with platelet rich fibrin in the management of Miller class II gingival recession

Jagmohan Singh, Vipin Bharti • Dental Research Journal (2013)

Gingival recession is a complex phenomenon that may present numerous therapeutic challenges to the clinician. The laterally positioned flap is commonly used to cover isolated, denuded roots that have adequate donor tissue laterally and vest...

DOAJ Open Access (DOAJ) DOI: 10.4103/1735-3327.113370

Artificial Tears: A Systematic Review

Semp DA, Beeson D, Sheppard AL, Dutta D et al. • Clinical Optometry (2023)

David A Semp, Danielle Beeson, Amy L Sheppard, Debarun Dutta, James S Wolffsohn School of Optometry, College of Health and Life Sciences, Aston University, Birmingham, UKCorrespondence: James S Wolffsohn, Tel +44 121 2044140, Email j.s.w.wo...

DOAJ Open Access (DOAJ)

Association of inflammation and cognition in the elderly: A systematic review and meta-analysis

Sofia Leonardo, Felipe Fregni • Frontiers in Aging Neuroscience (2023)

BackgroundThe development of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) may be associated with an inflammatory process. Inflammatory cytokines may be a surrogate for systemic inflammation leading to worsening neurological ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnagi.2023.1069439

Effect of probiotics on cognitive function and cardiovascular risk factors in mild cognitive impairment and Alzheimer’s disease: an umbrella meta-analysis

Bin Xiao, Lina Fu, Zhe Yang, Guran Yu • Journal of Health, Population and Nutrition (2025)

Abstract Background This umbrella meta-analysis evaluates the effects of probiotics on cognitive function and metabolic health in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) by synthesizing findings from meta-analyses of ra...

DOAJ Open Access (DOAJ) DOI: 10.1186/s41043-025-00816-3

<i>Carthamus tinctorius</i> Suppresses LPS-Induced Anti-Inflammatory Responses by Inhibiting the MAPKs/NF-κB Signaling Pathway in HaCaT Cells

So-Yeon Kim, Minji Hong, Ponnuvel Deepa, Kandhasamy Sowndhararajan et al. • Scientia Pharmaceutica (2023)

This study aimed to elucidate the anti-inflammatory activity of C. tinctorius leaves by measuring inflammatory parameters such as nitric oxide (NO) production and mRNA expression of iNOS, interleukin-6 (IL-6), and IL-1β in lipopolysaccharid...

DOAJ Open Access (DOAJ) DOI: 10.3390/scipharm91010014

Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways

Elliya Park, Lily Yi Li, Chunsheng He, Azhar Z. Abbasi et al. • Advanced Science (2023)

Abstract Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bi...

DOAJ Open Access (DOAJ) DOI: 10.1002/advs.202207238

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts

Camila Fabiani, Camila Fabiani, Silvia S. Antollini, Silvia S. Antollini • Frontiers in Cellular Neuroscience (2019)

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with satu...

DOAJ Open Access (DOAJ) DOI: 10.3389/fncel.2019.00309

Effects of the Brazilian Native Fruit Jaboticaba (<i>Plinia cauliflora</i>) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models

Ligia Soares Lima, Jessyca Sousa de Brito, Marcelo Ribeiro-Alves, Karen Salve Coutinho-Wolino et al. • Foods (2025)

Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14234030

Synergistic effect of mesenchymal stem cell-derived extracellular vesicle and miR-137 alleviates autism-like behaviors by modulating the NF-κB pathway

Qian Qin, Zhiyan Shan, Lei Xing, Yutong Jiang et al. • Journal of Translational Medicine (2024)

Abstract Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental disorder predominant in childhood. Despite existing treatments, the benefits are still limited. This study explored the effectiveness of mesenchymal stem cell-deri...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12967-024-05257-w

Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19

Irandi Putra Pratomo, Dimas R. Noor, Kusmardi Kusmardi, Andriansjah Rukmana et al. • International Journal of Inflammation (2021)

Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a ...

DOAJ Open Access (DOAJ) DOI: 10.1155/2021/1653392

Identification of functional pathways for regenerative bioactivity of selected renal cells

Wei Sha, Timothy Bertram, Deepak Jain, Cory Brouwer et al. • Stem Cell Research & Therapy (2022)

Abstract Background Selected renal cells (SRC) are in Phase II clinical trials as a kidney-sourced, autologous, tubular epithelial cell-enriched cell-based therapy for chronic kidney disease (CKD). In preclinical studies with rodent models ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13287-022-02713-6

Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy

O. A. Gromova, I. Yu. Torshin, A. G. Moiseenok • Фармакоэкономика (2025)

Background. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect ...

DOAJ Open Access (DOAJ) DOI: 10.17749/2070-4909/farmakoekonomika.2024.285

miR-130a-3p Exacerbates Sepsis-Induced Cardiac Dysfunction by Promoting Inflammation and Targeting PDK4

Jinyu Liu, Xiaowei Yuan, Wei Chen, Dongqin Shen • Clinical and Applied Thrombosis/Hemostasis (2026)

Background Sepsis is frequently complicated by systemic inflammatory injury and cardiac dysfunction, which serve as risk factors of adverse clinical outcomes and increased mortality risk. To clarify the function of miR-130a-3p in sepsis dia...

DOAJ Open Access (DOAJ) DOI: 10.1177/10760296261468449