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Single-cell RNA sequencing to detect age-associated genes that identify senescent cells in the liver of aged mice

Yuta Doshida, Shinichi Hashimoto, Sadahiro Iwabuchi, Yuka Takino et al. • Scientific Reports (2023)

Abstract Senescent cells are predicted to occur and increase in animal tissues with aging. However, senescent cells in the tissues of aged animals remain to be identified. We refer to the marker genes to identify senescent cells in tissues ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-023-41352-6

<i>Sechium edule</i> var. <i>nigrum spinosum</i> (Chayote) Increases the mRNA Expression of Genes Encoding Sirtuins in Older Adults with Type 2 Diabetes Mellitus

Graciela Gavia-García, David Hernández-Álvarez, Taide Laurita Arista-Ugalde, Itzen Aguiñiga-Sánchez et al. • Molecules (2026)

Consumption of Sechium edule var. nigrum spinosum has antioxidant and hypoglycemic effects. Regarding the former, certain signaling pathways that influence these effects have already been proposed; however, the underlying molecular mechanis...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules31071182

Red Blood Cells as Potential Repositories of MicroRNAs in the Circulatory System

Liping Sun, Yang Yu, Beifang Niu, Beifang Niu et al. • Frontiers in Genetics (2020)

The amount of erythrocyte-derived microRNAs (miRNAs) represents the majority of miRNAs expressed in whole blood. miR-451, miR-144, and miR-486, which are abundant in red blood cells (RBCs), are involved in the process of erythropoiesis and ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fgene.2020.00442

Induced Local and Systemic Defense Responses in Tomato Underlying Interactions Between the Root-Knot Nematode Meloidogyne incognita and the Potato Aphid Macrosiphum euphorbiae

Crispus M. Mbaluto, Crispus M. Mbaluto, Esraa M. Ahmad, Anne Mädicke et al. • Frontiers in Plant Science (2021)

Plants mediate interactions between different herbivores that attack simultaneously or sequentially aboveground (AG) and belowground (BG) organs. The local and systemic activation of hormonal signaling pathways and the concomitant accumulat...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpls.2021.632212

Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible <it>IRF1 </it>gene

Auriemma Lauren B, Shah Shaili, Linden Lara M, Henriksen Melissa A • Epigenetics & Chromatin (2012)

Abstract Background The tumor suppressor menin (MEN1) is mutated in the inherited disease multiple endocrine neoplasia type I, and has several documented cellular roles, including the activation and repression of transcription effected by s...

DOAJ Open Access (DOAJ) DOI: 10.1186/1756-8935-5-2

HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis

Guy Karlebach, Peter Hansen, Diogo FT Veiga, Robin Steinhaus et al. • Genome Biology (2020)

Abstract We present Hierarchical Bayesian Analysis of Differential Expression and ALternative Splicing (HBA-DEALS), which simultaneously characterizes differential expression and splicing in cohorts. HBA-DEALS attains state of the art or be...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13059-020-02072-6

Identifying strawberry DOF family transcription factors and their expressions in response to crown rot

Chun LUO, Yuyang HU, Bo SHU • Notulae Botanicae Horti Agrobotanici Cluj-Napoca (2022)

Crown rot is one of the most destructive diseases of cultivated strawberry. The DOF family transcription factors, which involved in biotic stress, has not been studied in responding to strawberry crown rot. In this study, the DOFs of Fragar...

DOAJ Open Access (DOAJ) DOI: 10.15835/nbha50112640

Green Synthesized Zinc Oxide Nanoparticles Using <i>Moringa olifera</i> Ethanolic Extract Lessens Acrylamide-Induced Testicular Damage, Apoptosis, and Steroidogenesis-Related Gene Dysregulation in Adult Rats

Gomaa Mostafa-Hedeab, Amany Behairy, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed et al. • Antioxidants (2023)

This study assessed the possible protective role of green synthesized zinc oxide nanoparticles using Moringa olifera leaf extract (MO-ZNPs) in acrylamide (ACR)-induced reproductive dysfunctions in male rats. ACR (20 mg/kg b.wt/day) and/or M...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox12020361

Methyl Jasmonate and Zinc Sulfate Induce Secondary Metabolism and Phenolic Acid Biosynthesis in Barley Seedlings

Xin Tian, Renjiao Zhang, Zhengfei Yang, Weiming Fang • Plants (2024)

This study aimed to reveal the impact of MeJA and ZnSO4 treatments on the physiological metabolism of barley seedlings and the content of phenolic acid. The results showed that MeJA (100 μM) and ZnSO4 (4 mM) treatments effectively increased...

DOAJ Open Access (DOAJ) DOI: 10.3390/plants13111512

Alleviation effect of glycyrrhetinic acid on zearalenone-induced reproductive toxicity in replacement gilts

Li-Tao Che, Li-Tao Che, Ahmed H. El-Sappah, Ahmed H. El-Sappah et al. • Frontiers in Veterinary Science (2025)

IntroductionThis study investigated whether glycyrrhetinic acid (GA) can alleviate the reproductive toxicity of Zearalenone (ZEN) in replacement gilts.MethodsEighty Landrace × Yorkshire gilts were randomly assigned to four dietary groups: c...

DOAJ Open Access (DOAJ) DOI: 10.3389/fvets.2025.1636738

NLRP3 Inflammasome-Mediated Pyroptosis Pathway Contributes to the Pathogenesis of Candida albicans Keratitis

Huifang Lian, Huifang Lian, Huifang Lian, Huifang Lian et al. • Frontiers in Medicine (2022)

PurposeFungal keratitis is a sight-threatening corneal infection caused by fungal pathogens, and the pathogenic mechanisms have not been fully elucidated. The aim of this study was to determine whether NOD-like receptor family pyrin domain ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.845129

Postbiotics: From emerging concept to application

Sunita Aggarwal, Vandana Sabharwal, Pragya Kaushik, Anushka Joshi et al. • Frontiers in Sustainable Food Systems (2022)

The microbiome innovation has resulted in an umbrella term, postbiotics, which refers to non-viable microbial cells, metabolic byproducts and their microbial components released after lysis. Postbiotics, modulate immune response, gene expre...

DOAJ Open Access (DOAJ) DOI: 10.3389/fsufs.2022.887642

A Benzimidazole-Based N-Heterocyclic Carbene Derivative Exhibits Potent Antiproliferative and Apoptotic Effects against Colorectal Cancer

Sarah Al-Nasser, Maha Hamadien Abdulla, Noura Alhassan, Mansoor-Ali Vaali-Mohammed et al. • Medicina (2024)

Background and Objectives: Colorectal cancer (CRC) remains a major global health issue. Although chemotherapy is the first-line treatment, its effectiveness is limited due to drug resistance developed in CRC. To overcome resistance and impr...

DOAJ Open Access (DOAJ) DOI: 10.3390/medicina60091379

Expression of Renal Vitamin D and Phosphatonin-Related Genes in a Sheep Model of Osteoporosis

Keren E. Dittmer, Anastasia Chernyavtseva, Jonathan C. Marshall, Diana Cabrera et al. • Animals (2021)

Osteoporosis is a significant public health issue around the world, with post-menopausal osteoporosis due to estrogen deficiency resulting in approximately ¾ of cases. In this study, 18 aged Merino ewes were ovariectomized, and 10 were cont...

DOAJ Open Access (DOAJ) DOI: 10.3390/ani12010067

Performance of computational algorithms to deconvolve heterogeneous bulk ovarian tumor tissue depends on experimental factors

Ariel A. Hippen, Dalia K. Omran, Lukas M. Weber, Euihye Jung et al. • Genome Biology (2023)

Abstract Background Single-cell gene expression profiling provides unique opportunities to understand tumor heterogeneity and the tumor microenvironment. Because of cost and feasibility, profiling bulk tumors remains the primary population-...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13059-023-03077-7

Growing functional modules from a seed protein via integration of protein interaction and gene expression data

Dimitrakopoulou Konstantina, Maraziotis Ioannis A, Bezerianos Anastasios • BMC Bioinformatics (2007)

Abstract Background Nowadays modern biology aims at unravelling the strands of complex biological structures such as the protein-protein interaction (PPI) networks. A key concept in the organization of PPI networks is the existence of dense...

DOAJ Open Access (DOAJ) DOI: 10.1186/1471-2105-8-408

Medical Informatics

Joseph Tan, IGI Global. • IGI Global eBooks (2009)

This set of book is a complete collection of cutting-edge medical IT research available in topics such as clinical knowledge management, medical informatics, and gene expression--Provided by publisher. | Includes bibliographical references ...

OPENALEX DOI: https://doi.org/10.4018/978-1-60566-050-9

Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats

Chuan Wang, Qian Wang, Guangming Xu, Guangming Xu et al. • Frontiers in Molecular Neuroscience (2024)

Prolonged or repeated exposure to stress elevates the risk of various psychological diseases, many of which are characterized by central nervous system dysfunction. Recent studies have demonstrated that circular RNAs (circRNAs) are highly a...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2024.1381098

Fipronil disturbs the antigen-specific immune responses and GABAergic gene expression in the ovalbumin-immunized BALB/c mice

Jui-Fang Kuo, Yin-Hua Cheng, Chun-Wei Tung, Chia-Chi Wang • BMC Veterinary Research (2024)

Abstract Background Fipronil (FPN) is a broad-spectrum pesticide and commonly known as low toxicity to vertebrates. However, increasing evidence suggests that exposure to FPN might induce unexpected adverse effects in the liver, reproductiv...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12917-024-03878-3

CD36‐Binding Amphiphilic Nanoparticles for Attenuation of α‐Synuclein‐Induced Microglial Activation

Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych et al. • Advanced NanoBiomed Research (2022)

Neuroinflammation is one of the hallmarks contributing to Parkinson's disease (PD) pathology, where microglial activation occurs as one of the earliest events, triggered by extracellular α‐synuclein (aSYN) binding to the cluster of differen...

DOAJ Open Access (DOAJ) DOI: 10.1002/anbr.202100120