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Showing 4 of 44 academic articles

Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage

Min Liu, Yuanyuan Li, Zhilin Deng, Ke Zhang et al. • Cell Death and Disease (2025)

Abstract Mutation in genes involved in DNA replication continuously disrupt DNA replication and give rise to genomic instability, a critical driver of oncogenesis. To prevent leukemia, immature T lymphocytes with genomic instability often u...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41419-025-07392-8

Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation

Meiyu Shao, Xiaoqing Zhang, Jiamei Sun, Hongyan Dong et al. • Exploration (2025)

ABSTRACT Saikosaponin b1 (Ssb1), a natural oleanane‐type triterpenoid saponin, exhibits antifibrosis activity by inhibiting the activation of hepatic stellate cells (HSCs), but the specific underlying molecular mechanisms are unknown. Here,...

DOAJ Open Access (DOAJ) DOI: 10.1002/EXP.70000

Unsupervised machine learning identifies distinct ALS molecular subtypes in post-mortem motor cortex and blood expression data

Heather Marriott, Renata Kabiljo, Guy P Hunt, Ahmad Al Khleifat et al. • Acta Neuropathologica Communications (2023)

Abstract Amyotrophic lateral sclerosis (ALS) displays considerable clinical and genetic heterogeneity. Machine learning approaches have previously been utilised for patient stratification in ALS as they can disentangle complex disease lands...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40478-023-01686-8