Academic Articles & Research Papers

Protocol for a cluster randomized controlled trial among young people and their peers to reduce substance use and inequitable gender beliefs in Southern Africa.

Intravascular Imaging-Guided Drug-Eluting Stenting for Complex Coronary Lesions: A Meta-Analysis of Randomized Controlled Trials.

Cost-Effectiveness of Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis for Intermediate-Risk Pulmonary Embolism: A PEERLESS Randomized Controlled Trial Post Hoc Analysis.

An mHealth Stress Management Intervention for Latino Millennial Caregivers: Pilot Feasibility Randomized Controlled Trial.

Intravascular imaging-guided versus angiography-guided percutaneous coronary intervention: a reconstructed individual participant data meta-analysis of randomized controlled trials of intravascular ultrasound- and optical coherence tomography-guided strategies.

Controlled postoperative red wine intake versus abstinence in habitual wine drinkers undergoing elective urological surgery (WISE): a translational randomized controlled trial assessing quality of life, surgical outcomes and complications.

Acupuncture versus sham acupuncture and usual care for Antiandrogen-Induced hot fLashes in prostate cancer (AVAIL): study protocol for a randomized clinical trial

Abstract Background Hot flashes are the common and debilitating symptom among prostate cancer (PCa) patients undergoing androgen deprivation therapy (ADT). Strong evidence from multiple rigorously designed studies indicated that pharmacolog...

CuddleCard: Protocol for a randomized controlled trial evaluating the effect of providing financial support to low-income mothers of preterm infants on parental caregiving in the neonatal intensive care unit (NICU)

Abstract Background Preterm birth is a leading cause of childhood mortality and developmental disabilities, with persistent socioeconomic disparities in incidence and outcomes. Maternal presence during prolonged neonatal intensive care unit...

Therapist-Supported Online Interventions for Children and Young People With Tic Disorders: Lessons Learned From a Randomized Controlled Trial and Considerations for Future Practice

In recent years, research into internet-based cognitive behavioral therapy (iCBT) has suggested that therapist-guided digital interventions have greater engagement, adherence, and effectiveness than self-directed digital therapies. While re...

Analyzing the influence of physical exercise interventions on social skills in children with autism spectrum disorder: insights from meta-analysis

IntroductionChildren diagnosed with autism spectrum disorder (ASD) commonly encounter difficulties in social interactions and communication, significantly affecting their overall wellbeing. One proposed strategy to address these challenges ...

Comparative efficacy of exercise interventions for cognitive health in older adults: A network meta-analysis

Background: Previous studies have consistently demonstrated that exercise mitigates cognitive decline in older adults. However, the most effective types of exercise, along with optimal frequency and duration of interventions, remain inadequ...

Effects of Dynamic Neuromuscular Stabilization on Lower Limb Muscle Activity, Pain, and Disability in Individuals with Chronic Low Back Pain: A Randomized Controlled Trial

Background and Objectives: Chronic low back pain (CLBP) is associated with altered neuromuscular control. Dynamic Neuromuscular Stabilization (DNS) targets core–limb coordination; however, its specific impact on lower-limb electromyographic...

Self-Managing Postoperative Pain with the Use of a Novel, Interactive Device: A Proof of Concept Study

Background. Pain is commonly experienced following surgical procedures. Suboptimal management is multifactorial. Objectives. The primary objective was to assess whether patients used a device (Navimed) to self-report pain over and above a n...

Artificial Tears: A Systematic Review

David A Semp, Danielle Beeson, Amy L Sheppard, Debarun Dutta, James S Wolffsohn School of Optometry, College of Health and Life Sciences, Aston University, Birmingham, UKCorrespondence: James S Wolffsohn, Tel +44 121 2044140, Email j.s.w.wo...

Optimal exercise type and dose to improve sleep quality in older adults: a systematic review and network meta-analysis

Abstract Background Sleep quality decreased can result in a major health issue in older people with age. While not all sleep changes are pathological in older people’s life, severe disturbances may lead to depression, cognitive impairments,...

Time-in-range and hypoglycemia in cognitive health of older adults with Type 2 diabetes: An emerging evidence synthesis

Type 2 diabetes mellitus (T2DM) is a recognized risk factor for cognitive decline and dementia, but the mechanisms linking glycemic dysregulation to brain health remain incompletely understood. Glycated hemoglobin captures long-term average...

Transcranial direct current stimulation combined with cognitive-behavioral interventions for depressive disorders: a systematic review and meta-analysis of sham-controlled randomized trials

IntroductionDepressive disorders are a prevalent psychiatric condition; major depressive disorder (MDD) specifically affects approximately 5.7% of adults worldwide and is associated with high levels of disability and disease burden. Althoug...

Systematic review and meta-analysis reveal positive therapeutic effects of music in brain damage rehabilitation

Brain damage (BD) caused by stroke, traumatic brain injury (TBI), or neurodegenerative conditions often results in persistent cognitive, motor, and emotional impairments. Music-based interventions (MI) have been explored as adjunctive rehab...

Effect of probiotics on cognitive function and cardiovascular risk factors in mild cognitive impairment and Alzheimer’s disease: an umbrella meta-analysis

Abstract Background This umbrella meta-analysis evaluates the effects of probiotics on cognitive function and metabolic health in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) by synthesizing findings from meta-analyses of ra...

Thematic structure of clinically oriented prefrontal function assessment and intervention research: a keyword network analysis

Abstract Background The prefrontal cortex (PFC) has been extensively investigated in relation to higher-order cognition, emotional regulation, and behavioural control, particularly within clinically oriented studies addressing psychiatric s...