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The Downregulation of eIF3a Contributes to Vemurafenib Resistance in Melanoma by Activating ERK via PPP2R1B

Shi-Long Jiang, Shi-Long Jiang, Zhi-Bin Wang, Zhi-Bin Wang et al. • Frontiers in Pharmacology (2021)

Vemurafenib, a BRAF V600E inhibitor, provides therapeutic benefits for patients with melanoma, but the frequent emergence of drug resistance remains a challenge. An understanding of the mechanisms underlying vemurafenib resistance may gener...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2021.720619

Assessing Acceptance and Intention to Use of Home Telemonitoring Among Patients with Liver Cirrhosis: Development and Initial Psychometric Validation of a TAM-Based Questionnaire

Ruxandra-Cristina Marin, Horia Păunescu, Călin Muntean, Daniel Vasile Balaban et al. • Diagnostics (2026)

Background/Objectives: Liver cirrhosis (LC) is a major cause of morbidity and mortality requiring continuous monitoring and early recognition of clinical deterioration. Home telemonitoring is increasingly considered a supportive strategy fo...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics16162635

Machine learning framework for early identification of high-spending Crohn’s disease patients using administrative claims

Jamieson D Gray, Lukasz S Wylezinski, Charles F Spurlock • BMJ Health & Care Informatics (2026)

Objectives To develop and evaluate a machine learning (ML) model that predicts Crohn’s disease (CD) patients responsible for the top quartile of healthcare spending.Methods De-identified commercial claims (2016–2018) from ~267 000 continuou...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjhci-2025-101761

Artificial intelligence-driven anthropometric assessment for young children: evaluating the accuracy and practicality of a digital image-based length and weight prediction tool

Fabian Yap, Daniel Chan, Mei Chien Chua, Matthew Hadimaja et al. • BMJ Health & Care Informatics (2025)

Background Monitoring early childhood growth is vital, as growth faltering could indicate nutritional or health issues requiring prompt intervention. Our study’s aim was to assess the performance of a length-weight artificial intelligence (...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjhci-2025-101540

Deep learning prediction of pathological complete response in breast cancer using Mamba architecture

Wenchuan Zhang, Shuwan Zhang, Fengling Li, Yuanyuan Zhao et al. • npj Digital Medicine (2026)

Abstract Deep learning is capable of efficiently predicting the therapeutic efficacy of neoadjuvant chemotherapy (NAC) in breast cancer. However, current methods predominantly rely on convolutional neural networks or transformer architectur...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41746-026-02849-2

Development and validation of an interpretable machine learning model for predicting the risk of coronary heart disease risk in diabetes mellitus patients: a dual-center retrospective study

Ye Kuang, Yan Yu, Jing Li, Chuanmei Peng et al. • BMC Medical Informatics and Decision Making (2026)

Abstract Background Diabetes mellitus (DM) combined with coronary heart disease (CHD) significantly increases the risk of cardiovascular events with a greater mortality rate. Therefore, establishing a predictive model can help DM patients r...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12911-026-03461-w

Identification of brain regions predicting epileptogenesis by serial [18F]GE-180 positron emission tomography imaging of neuroinflammation in a rat model of temporal lobe epilepsy

Vera Russmann, Matthias Brendel, Erik Mille, Angela Helm-Vicidomini et al. • NeuroImage: Clinical (2017)

Excessive activation of inflammatory signaling pathways seems to be a hallmark of epileptogenesis. Positron emission tomography (PET) allows in vivo detection of brain inflammation with spatial information and opportunities for longitudinal...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2017.04.003

Exploring feature selection and classification methods for predicting heart disease

Robinson Spencer, Fadi Thabtah, Neda Abdelhamid, Michael Thompson • Digital Health (2020)

Machine learning has been used successfully to improve the accuracy of computer-aided diagnosis systems. This paper experimentally assesses the performance of models derived by machine learning techniques by using relevant features chosen b...

DOAJ Open Access (DOAJ) DOI: 10.1177/2055207620914777

Integrating machine learning algorithms and explainable artificial intelligence approach for predicting patient unpunctuality in psychiatric clinics

Alireza Kasaie, Suchithra Rajendran • Healthcare Analytics (2023)

This study addresses patient unpunctuality, a major concern affecting patient waiting time, resource utilization, and quality of care. We develop and compare four machine learning models, including multinomial logistic regression, decision ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.health.2023.100242

ODE, regression, and ANN models for energy forecasting: Egypt as a study case

Mohey Eldeen H. H. Ali, Ahmed F. Tayel, Hossam M. Ezzat, Hesham A. Elkaranshawy • Alexandria Engineering Journal (2025)

Energy plays a crucial role in national development, influencing critical sectors such as industry, agriculture, healthcare, and education. Accurate energy consumption prediction is essential for efficient energy management, helping prevent...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.aej.2025.04.037

Poly (ADP-ribose) Polymerase Promoter Hypermethylation Predispose Females to Breast Cancer

Hussein Sabit, Shaimaa Nazir, Shimaa Abdel-Ghany, Osama A. Said et al. • Asian Pacific Journal of Cancer Biology (2019)

Being the most common cause of female deaths worldwide, breast cancer (BC) is intensively studied over the last two decades. In the present investigation, we evaluated the promoter methylation of three cancer-related genes; PARP-1, p21, and...

DOAJ Open Access (DOAJ) DOI: 10.31557/apjcb.2019.4.1.1-5

Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy

Wei Liu, Yan Xu, Yi Wang, Lugui Qiu et al. • Journal for ImmunoTherapy of Cancer (2024)

Background Over 50% of patients with relapsed or refractory large B-cell lymphoma (r/r LBCL) receiving CD19-targeted chimeric antigen receptor (CAR19) T-cell therapy fail to achieve durable remission. Early identification of relapse or prog...

DOAJ Open Access (DOAJ) DOI: 10.1136/jitc-2023-008450

FAKTOR-FAKTOR YANG MEMPENGARUHI INTENSI ENTREPRENEURIAL PADA SISWA DAN MAHASISWA DI SURABAYA

Krimsi Budi Sienatra, Metta Padmalia • Jurnal Ilmiah Bisnis dan Ekonomi Asia (2018)

This study aims to look at the early stages of the birth of a business or at the stage of conception and preparation. Specifically, the purpose of this study is to develop and test empirically the determinants of entrepreneurial intentions ...

DOAJ Open Access (DOAJ) DOI: 10.32812/jibeka.v12i1.12

Development of a Scoring System to Predict the Treatment Success for Nonoperative Management of Peptic Ulcer Perforation: A Secondary Data Analysis of PPAP Study

Kei Ito, Akira Endo, Hiromasa Hoshi, Koji Ito et al. • Annals of Gastroenterological Surgery (2026)

ABSTRACT Background Although surgical treatment is the primary measure for patients with perforated peptic ulcer (PPU), nonoperative management (NOM) has become a common alternative. However, risk score models predicting the success of NOM ...

DOAJ Open Access (DOAJ) DOI: 10.1002/ags3.70074

RadarDiT: An advanced radar echo extrapolation model for three gorges reservoir area via diffusion transformer

Jiaquan Wan, Junchao Wang, Wei Zhang, Hao Song et al. • Journal of Hydrology: Regional Studies (2025)

Study region: The Three Gorges Reservoir Area (TGRA) Study focus: TGRA faces increasing vulnerability to extreme precipitation events driven by complex convective weather systems. Radar echo extrapolation—predicting future precipitation pat...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ejrh.2025.102703

Bayesian ANN-Based Prediction and Multi-Objective Optimization of Tribological Behavior in Magnesium Alloy AZ91D at Elevated Temperature Using Pareto GA

Beniyel Muthuraj, Sivapragash Murugesan, Rajesh Rajamony, Michael Thomas Rex Francis • Materials Research (2025)

This study uses an artificial neural network (ANN) model to predict the wear rate and friction coefficient of the magnesium alloy AZ91D, based on experimental data from a pin-on-disc tribometer. The model includes three essential process pa...

DOAJ Open Access (DOAJ) DOI: 10.1590/1980-5373-mr-2025-0388

Prediction of Sport Participation Motivation among Male Adolescent Students in School Physical Education Classes Based on Basic Psychological Needs and Social Responsibility

Hafez Padervand, Banafsheh Hassanvand, Kaveh Rostami, Asma soleimani • روان‌شناسی تربیتی (2026)

The aim of this study was to predict the sport participation motivation of male adolescent students in school physical education classes based on basic psychological needs and social responsibility. The research method was a correlational s...

DOAJ Open Access (DOAJ) DOI: 10.22054/jep.2026.88261.4266

Predicting hospital admissions from individual patient data (IPD): an applied example to explore key elements driving external validity

Rafael Perera, Marjan Van Den Akker, Kym I E Snell, Joerg J Meerpohl et al. • BMJ Open (2021)

Objective To explore factors that potentially impact external validation performance while developing and validating a prognostic model for hospital admissions (HAs) in complex older general practice patients.Study design and setting Using ...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2020-045572