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Showing 20 of 130 academic articles

Synergistic effect of mesenchymal stem cell-derived extracellular vesicle and miR-137 alleviates autism-like behaviors by modulating the NF-κB pathway

Qian Qin, Zhiyan Shan, Lei Xing, Yutong Jiang et al. • Journal of Translational Medicine (2024)

Abstract Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental disorder predominant in childhood. Despite existing treatments, the benefits are still limited. This study explored the effectiveness of mesenchymal stem cell-deri...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12967-024-05257-w

RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.

Brianna Dufek, Daniel T Meehan, Duane Delimont, Kevin Wilhelm et al. • PLoS ONE (2020)

Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels o...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0237907

Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory

Suhel Tamboli, Sanjay Singh, Dimitry Topolnik, Mohamed El Amine Barkat et al. • Cell Reports (2024)

Summary: In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, the specific behavioral conditions that lead to circuit disinhibition remai...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.celrep.2024.114115

Molecular docking and mouse modeling suggest CMKLR1 and INSR as targets for improving PCOS phenotypes by minocycline

Mahdie Kian, Elham Hosseini, Tooba Abdizadeh, Taimour Langaee et al. • EXCLI Journal : Experimental and Clinical Sciences (2022)

Polycystic ovary syndrome (PCOS) is the most common cause of women’s infertility. Some inflammatory pathways play a pivotal role in the pathogenesis of PCOS. This study aimed to investigate the possible beneficial effects of minocycline on ...

DOAJ Open Access (DOAJ) DOI: 10.17179/excli2021-4534

Volcanic Pozzolan from the Phlegraean Fields in the Structural Mortars of the Roman Temple of Nora (Sardinia)

Simone Dilaria, Caterina Previato, Jacopo Bonetto, Michele Secco et al. • Heritage (2023)

In this paper, we discuss the presence of volcanic pozzolans in the structural mortars of the Roman Temple of Nora in Sardinia (3rd c. AD), represented by pyroclastic rocks (pumices and tuffs) employed as coarse and fine aggregates. The pro...

DOAJ Open Access (DOAJ) DOI: 10.3390/heritage6010030

Computed Tomographic and Histopathological Characteristics of 13 Equine and 10 Feline Oral and Sinonasal Squamous Cell Carcinomas

Carina Strohmayer, Andrea Klang, Sibylle Kneissl • Frontiers in Veterinary Science (2020)

Squamous cell carcinoma (SCC) is the most common equine sinonasal and feline oral tumour. This study aimed to describe the computed tomographic and histopathological characteristics of equine and feline SCC. Thirteen horses and 10 cats that...

DOAJ Open Access (DOAJ) DOI: 10.3389/fvets.2020.591437

Isoliquiritigenin Attenuates Staphylococcus aureus Adhesion and Invasion to Counteract Staphylococcus aureus Pathogenicity and Infection

Lili Tian, Lili Tian, Jian Sun, Hong Jiang et al. • Frontiers in Cellular and Infection Microbiology (2025)

IntroductionMethicillin-resistant Staphylococcus aureus (MRSA) is a major clinical challenge due to its virulence and multidrug resistance. Antivirulence strategies targeting key pathogenic mechanisms without affecting bacterial viability p...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcimb.2025.1686699

Laboratorul de cercetare şi încercări higrotermice, instrument de verificare experimentală a calităţii construcţiilor, echipamentelor şi gestionării eficiente a energiei

Constantin Bogos, Constantin Miron • Urbanism. Arhitectura. Constructii (2010)

This paper seeks to present the technical conditions and the main types of research and experimental verifications being conducted by the Laboratory of Research and Hygrothermal Testing for Materials, Building Elements and Parts at INCD URB...

DOAJ Open Access (DOAJ)

Antidiarrheal and antimicrobial profiles extracts of the leaves from Trichilia emetica Vahl. (Meliaceae)

Kiessoun Konaté, Kassi Yomalan, Oksana Sytar, Marian Brestic • Asian Pacific Journal of Tropical Biomedicine (2015)

Objective: To evaluate anti-diarrhoeal and antimicrobial activities of the bioactive fraction of Trichilia emetica in order to provide a scientific basis for the management of gastroenteritis in Burkina Faso. Methods: To do this, polyphenol...

DOAJ Open Access (DOAJ) DOI: 10.1016/S2221-1691(15)30012-5

Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli

Yasushi Hirasawa, Aiko Muramatsu, Yoshio Suzuki, Tadashi Nagamatsu • Journal of Pharmacological Sciences (2006)

To elucidate the involvement of cyclooxygenase (COX) in degradation of aggregated protein in diabetic glomeruli, we used streptozotocin (STZ)-induced diabetic mice and aggregated bovine serum albumin (a-BSA) as a model protein. There was a ...

DOAJ Open Access (DOAJ) DOI: 10.1254/jphs.FPJ06010X

Mechanism analysis of mechanical extraction of Pleioblastus amarus fibers by saturated steam pretreatment

Xiaofeng Xu, Weipeng Yu, Xingduo Fan, Zhenhong Gong et al. • Scientific Reports (2025)

Abstract Currently, bamboo fibers (BFs) are commonly processed through alkali boiling softening pretreatment, which generates wastewater that poses environmental pollution risks. This process is also complex and requires significant human a...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-88059-4

Non-invasive large-scale imaging of concurrent neuronal, astrocytic, and hemodynamic activity with hybrid multiplexed fluorescence and magnetic resonance imaging (HyFMRI)

Zhenyue Chen, Yi Chen, Irmak Gezginer, Qingxiang Ding et al. • Light: Science & Applications (2025)

Abstract A critical gap currently exists in systematic understanding and experimental validation of the role of astrocytes in neurovascular coupling and their functional links with other brain cells. Despite a broad selection of functional ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41377-025-02003-9

Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice

Clinton M. Hasenour, Arion J. Kennedy, Tomasz Bednarski, Irina A. Trenary et al. • Journal of Lipid Research (2020)

Fatty liver involves ectopic lipid accumulation and dysregulated hepatic oxidative metabolism, which can progress to a state of elevated inflammation and fibrosis referred to as nonalcoholic steatohepatitis (NASH). The factors that control ...

DOAJ Open Access (DOAJ) DOI: 10.1194/jlr.RA119000183

Toxicity and biodistribution comparison of functionalized nanodiamonds, quantum dot nanocarbons and gold nanoparticles

Elena Alexander, Kam W. Leong • Frontiers in Nanotechnology (2025)

IntroductionNanomaterials are extensively utilized in applications ranging from electronics to biomedical therapies; however, their widespread use has prompted concerns about potential toxicity in humans. Understanding the biodistribution a...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnano.2025.1512622

The Effects of Alkaline Pretreatment on Agricultural Biomasses (Corn Cob and Sweet Sorghum Bagasse) and Their Hydrolysis by a Termite-Derived Enzyme Cocktail

Mpho. S. Mafa, Samkelo Malgas, Abhishek Bhattacharya, Konanani Rashamuse et al. • Agronomy (2020)

Sweet sorghum bagasse (SSB) and corncob (CC) have been identified as promising feedstocks for the production of second-generation biofuels and other value-added chemicals. In this study, lime (Ca(OH)2) and NaOH pretreatment efficacy for dec...

DOAJ Open Access (DOAJ) DOI: 10.3390/agronomy10081211

Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease

Stewart F. Graham, Nolwen L. Rey, Zafer Ugur, Ali Yilmaz et al. • Metabolites (2018)

For people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodrom...

DOAJ Open Access (DOAJ) DOI: 10.3390/metabo8040071

Development, modelling and optimization of process parameters on the tensile strength of aluminum, reinforced with pumice and carbonated coal hybrid composites for brake disc application

Tanimu Kogi Ibrahim, Danjuma Saleh Yawas, Julius Thaddaeus, Bashar Danasabe et al. • Scientific Reports (2024)

Abstract This study focuses on optimizing double stir casting process parameters to enhance the tensile strength of hybrid composites comprising aluminum alloy, brown pumice, and coal ash, intended for brake disc applications. Analytical te...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-024-67476-x

Relationship between Pb relative bioavailability and bioaccessibility in phosphate amended soil: Uncertainty associated with predicting Pb immobilization efficacy using in vitro assays

Farzana Kastury, Silvia Placitu, John Boland, Ranju R. Karna et al. • Environment International (2019)

In this study, an in vitro in vivo correlation (IVIVC) between Pb in vitro bioaccessibility (IVBA) and relative bioavailability (RBA) was explored to determine whether the efficacy of Pb immobilization in phosphate amended soils could be pr...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.envint.2019.104967

Transcriptomes Suggest That Pinniped and Cetacean Brains Have a High Capacity for Aerobic Metabolism While Reducing Energy-Intensive Processes Such as Synaptic Transmission

Cornelia Geßner, Alena Krüger, Lars P. Folkow, Wilfrid Fehrle et al. • Frontiers in Molecular Neuroscience (2022)

The mammalian brain is characterized by high energy expenditure and small energy reserves, making it dependent on continuous vascular oxygen and nutritional supply. The brain is therefore extremely vulnerable to hypoxia. While neurons of mo...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2022.877349