Academic Articles & Research Papers

Fyn Kinase: A Potential Target in Glucolipid Metabolism and Diabetes Mellitus

Fyn is widely involved in diverse cellular physiological processes, including cell growth and survival, and has been implicated in the regulation of energy metabolism and the pathogenesis of diabetes mellitus through multiple pathways. Fyn ...

Prevalence of comorbid depression and associated factors among hospitalized patients with type 2 diabetes mellitus in Hunan, China

Abstract Background Depression and diabetes are major health challenges, with heavy economic social burden, and comorbid depression in diabetes could lead to a wide range of poor health outcomes. Although many descriptive studies have highl...

Worldwide productivity and research trend of publications concerning extracellular vesicles role in fibrosis: A bibliometric study from 2013 to 2022

Background: Fibrosis is a heavy burden on the global healthcare system. Recently, an increasing number of studies have demonstrated that Extracellular vesicles play an important role in intercellular communication under both physiological a...

The Advances of Single-Cell RNA-Seq in Kidney Immunology

Kidney diseases are highly prevalent and treatment is costly. Immune cells play important roles in kidney diseases; however, it has been challenging to investigate the contribution of each cell type in kidney pathophysiology. Recently, the ...

Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions

Summary: Detecting antibodies, particularly those targeting donor human leukocyte antigens in organ transplantation and self-antigens in autoimmune diseases, is crucial for diagnosis and therapy. Radioprotective 105 (RP105), a Toll-like rec...

Development and evaluation of Retrieval-Augmented Generation (RAG) and GraphRAG for guideline-based clinical decision support in chronic kidney disease.

Explainable and reliable kidney CT image classification using self-supervised DeiT-Tiny transformer

IntroductionKidney-related disorders are one of the global health concerns that require timely detection to prevent severe health complications. The use of computed tomography (CT) images for accurate classification of kidney diseases is im...

An explainable machine learning framework for cross-dataset chronic kidney disease risk prediction using hybrid data balancing.

Platelet-derived microparticles induce CD8(+) T cell senescence in chronic kidney disease via the transfer of microRNA-550a-5p.

Health Equity Journal: Special Issue Guest Editorial

The practices of contemporary clinical decision-making and care rely heavily on racial biological essentialism, which is a set of ideas originating in modern science that describes populations as comprising distinct subpopulations with uniq...

Biomaterial Engineering for Spatiotemporal Regulation of Exosome Functions: From Design Principles to Key Applications in Regenerative Medicine

As natural nanoscale intercellular messengers, exosomes exhibit considerable potential in modulating inflammation, angiogenesis, immunoregulation, and tissue remodeling, making them attractive candidates for regenerative medicine. However, ...