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Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges

Kirsten M. Wright, Janis McFerrin, Armando Alcázar Magaña, Armando Alcázar Magaña et al. • Frontiers in Nutrition (2022)

Botanical products are frequently sold as dietary supplements and their use by the public is increasing in popularity. However, scientific evaluation of their medicinal benefits presents unique challenges due to their chemical complexity, i...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnut.2021.799137

Why did an effective Dutch complex psycho-social intervention for people with dementia not work in the German healthcare context? Lessons learnt from a process evaluation alongside a multicentre RCT

Sebastian Voigt-Radloff, Maud Graff, Myrra Vernooij-Dassen, Rainer Leonhart et al. • BMJ Open (2011)

Background The positive effects of the Dutch Community Occupational Therapy in Dementia programme on patients' daily functioning were not found in a multicentre randomised controlled trial (RCT) in Germany.Objectives To evaluate possible ef...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2011-000094

Local, collaborative, stepped, and personalized care management for older people with chronic diseases – results from the randomized controlled LoChro-trial

Gloria Metzner, Lukas Maximilian Horstmeier, Jürgen Bengel, Eva Maria Bitzer et al. • BMC Geriatrics (2023)

Abstract Background In the aging population of Western societies, an increasing number of older adults have multiple chronic diseases. As multifaceted health problems imply the involvement of several healthcare professionals, multimorbid ol...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-023-03797-2

What motivates SARS-CoV-2 vaccine trial participants? A pre- and post-participation survey study

Olivia A. C. Lamers, Meta Roestenberg, Martine C. de Vries, Marie-Astrid Hoogerwerf • Trials (2024)

Abstract Background Scientific advancement, including the testing and licensing of new drugs, relies heavily on clinical trials with healthy individuals. The motivations of clinical trial participants have been discussed intensively, as som...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13063-024-08582-z

Robotic Arthroplasty Clinical and cost Effectiveness Randomised controlled trial (RACER-knee): a study protocol

Martin Underwood, Charles E Hutchinson, Helen Parsons, James Mason et al. • BMJ Open (2023)

Introduction Robotic-assisted knee replacement systems have been introduced to healthcare services worldwide in an effort to improve clinical outcomes for people, although high-quality evidence that they are clinically, or cost-effective re...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2022-068255

Identification of Eusynstyelamide B as a Potent Cell Cycle Inhibitor Following the Generation and Screening of an Ascidian-Derived Extract Library Using a Real Time Cell Analyzer

Michelle S. Liberio, Martin C. Sadowski, Colleen C. Nelson, Rohan A. Davis • Marine Drugs (2014)

Ascidians are marine invertebrates that have been a source of numerous cytotoxic compounds. Of the first six marine-derived drugs that made anticancer clinical trials, three originated from ascidian specimens. In order to identify new anti-...

DOAJ Open Access (DOAJ) DOI: 10.3390/md12105222

Psychological STress, Anxiety, and Depression After miscarriage in comparison to successful pregnancy and abortion: design and protocol for the observational cohort study STRADA

Maarit Mentula, Oskari Heikinheimo, Katri Räikkönen, Heini Sorasto et al. • BMJ Open (2026)

Introduction Miscarriage occurs in 15%–20% of clinically recognised pregnancies. It may cause acute or prolonged psychological distress such as anxiety, depression and post-traumatic stress disorder (PTSD). Data on symptom severity and dura...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2026-127865

The efficacy of Narrative Exposure Therapy for Children (KIDNET) as a treatment for traumatized young refugees versus treatment as usual: update to the study protocol for the multi-center randomized controlled trial YOURTREAT

Jasmin Wittmann, Melissa Groß, Claudia Catani, Telja Schmidt et al. • Trials (2022)

Abstract Background The trial YOURTREAT aims to compare the pragmatic, short-term psychotherapy Narrative Exposure Therapy for Children (KIDNET) with treatment as usual (TAU) for the treatment of young refugees in Germany. This update outli...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13063-022-06288-8

Vesicular Carriers for Phytochemical Delivery: A Comprehensive Review of Techniques and Applications

Shery Jacob, Fathima Sheik Kather, Sai H. S. Boddu, Rekha Rao et al. • Pharmaceutics (2025)

Natural substances, especially those derived from plants, exhibit a diverse range of therapeutic benefits, such as antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. Nevertheless, their use in clinical settings is freque...

DOAJ Open Access (DOAJ) DOI: 10.3390/pharmaceutics17040464

Digital health technology in clinical trials

Mirja Mittermaier, Kaushik P. Venkatesh, Joseph C. Kvedar • npj Digital Medicine (2023)

Digital health technologies (DHTs) have brought several significant improvements to clinical trials, enabling real-world data collection outside of the traditional clinical context and more patient-centered approaches. DHTs, such as wearabl...

OPENALEX cc-by DOI: https://doi.org/10.1038/s41746-023-00841-8 PMC: 10195788

Health technology in perspective

Tae‐Il Kim • Journal of Periodontal & Implant Science (2015)

The ongoing development of information and communication technology (ICT) is taking the healthcare industry to the next level. It allows an independent healthcare system by which anyone can easily obtain tne real-time measurement of individ...

OPENALEX cc-by-nc DOI: https://doi.org/10.5051/jpis.2015.45.1.1 PMC: 4341201

Clinical and cost-effectiveness of a standardised diagnostic assessment for children and adolescents with emotional difficulties: the STADIA multi-centre RCT

Kapil Sayal, Laura Wyatt, Louise Thomson, Grace Holt et al. • Health Technology Assessment (2025)

Background Emotional disorders are common in children and young people and can significantly impair their quality of life. Evidence-based treatments require a timely and appropriate diagnosis. The utility of standardised diagnostic assessme...

DOAJ Open Access (DOAJ) DOI: 10.3310/GJKS0519

HEALTH TECHNOLOGY ASSESSMENT

François Schubert • International Journal of Technology Assessment in Health Care (2002)

Increasingly, health technology assessment (HTA) is used to aid decisions on the reimbursement of pharmaceuticals or recommendations for their use. The pharmaceutical industry seeks to work in partnership with HTA agencies; however, this pr...

OPENALEX DOI: https://doi.org/10.1017/s0266462302000193

Real World Data in Health Technology Assessment of Complex Health Technologies

Milou Milou, Johan Pontén, Rick A. Vreman, Aukje K. Mantel-Teeuwisse et al. • Frontiers in Pharmacology (2022)

The available evidence on relative effectiveness and risks of new health technologies is often limited at the time of health technology assessment (HTA). Additionally, a wide variety in real-world data (RWD) policies exist among HTA organiz...

OPENALEX cc-by DOI: https://doi.org/10.3389/fphar.2022.837302 PMC: 8866967

Effect of Interactive eHealth Interventions on Improving Medication Adherence in Adults With Long-Term Medication: Systematic Review

Pouls, Bart P H, Vriezekolk, Johanna E, Bekker, Charlotte L, Linn, Annemiek J et al. • Journal of Medical Internet Research (2021)

BackgroundMedication nonadherence leads to suboptimal treatment outcomes, making it a major priority in health care. eHealth provides an opportunity to offer medication adherence interventions with minimal effort from health care providers ...

DOAJ Open Access (DOAJ) DOI: 10.2196/18901

Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau

Lauren E. McCollum, Sandhitsu R. Das, Long Xie, Robin de Flores et al. • NeuroImage: Clinical (2021)

Mild cognitive impairment (MCI) can be an early manifestation of Alzheimer’s disease (AD) pathology, other pathologic entities [e.g., cerebrovascular disease, Lewy body disease, LATE (limbic-predominant age-related TDP-43 encephalopathy)], ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2021.102717

Full-thickness skin graft versus split-thickness skin graft for radial forearm free flap donor site closure: protocol for a systematic review and meta-analysis

Jasper J.E. Moors, Zhibin Xu, Kunpeng Xie, Ashkan Rashad et al. • Systematic Reviews (2024)

Abstract Background The radial forearm free flap (RFFF) serves as a workhorse for a variety of reconstructions. Although there are a variety of surgical techniques for donor site closure after RFFF raising, the most common techniques are cl...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13643-024-02471-x

Longitudinal analysis of white matter and cortical lesions in multiple sclerosis

Mário João Fartaria, Tobias Kober, Cristina Granziera, Meritxell Bach Cuadra • NeuroImage: Clinical (2019)

Purpose: The goals of this study were to assess the performance of a novel lesion segmentation tool for longitudinal analyses, as well as to validate the generated lesion progression map between two time points using conventional and non-co...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2019.101938

Medical Informatics in Medical Research

Michel Anoumou Missinou, Saadou Issifou, Evelyn Anane‐Sarpong, Ibrahim I Abubakar et al. • Methods of Information in Medicine (2006)

OBJECTIVES: Computers are widely used for data management in clinical trials in the developed countries, unlike in developing countries. Dependable systems are vital for data management, and medical decision making in clinical research. Mon...

OPENALEX DOI: https://doi.org/10.1055/s-0038-1634108

A Brief Intervention to Increase Uptake and Adherence of an Internet-Based Program for Depression and Anxiety (Enhancing Engagement With Psychosocial Interventions): Randomized Controlled Trial

Philip J Batterham, Alison L Calear, Matthew Sunderland, Frances Kay-Lambkin et al. • Journal of Medical Internet Research (2021)

BackgroundPsychosocial, self-guided, internet-based programs are effective in treating depression and anxiety. However, the community uptake of these programs is poor. Recent approaches to increasing engagement (defined as both uptake and a...

DOAJ Open Access (DOAJ) DOI: 10.2196/23029