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A Benzimidazole-Based N-Heterocyclic Carbene Derivative Exhibits Potent Antiproliferative and Apoptotic Effects against Colorectal Cancer

Sarah Al-Nasser, Maha Hamadien Abdulla, Noura Alhassan, Mansoor-Ali Vaali-Mohammed et al. • Medicina (2024)

Background and Objectives: Colorectal cancer (CRC) remains a major global health issue. Although chemotherapy is the first-line treatment, its effectiveness is limited due to drug resistance developed in CRC. To overcome resistance and impr...

DOAJ Open Access (DOAJ) DOI: 10.3390/medicina60091379

Treatment seeking behaviors related to gonorrhea among female sex workers in 7 cities in Indonesia

Roselinda Roselinda, Nelly Puspandari • Health Science Journal of Indonesia (2014)

Abstrak Latar belakang:Gonore merupakan salah satu infeksi menular seksual yang menjadi permasalahan besar kesehatan terutama pada wanita penjaja seks (WPS) di Indonesia. Tujuan dari artikel ini adalah untuk melihat hubungan antara pola pen...

DOAJ Open Access (DOAJ) DOI: 10.22435/hsji.v4i2 Des.3438.87-92

Morbimortality in Patients Undergone an Operation for Intestinal Occlusion in General Surgery Service

Alexander Marchena Rodríguez, Reinaldo Jiménez Prendes, Julio César Sarmiento Sánchez • Revista Finlay (2015)

Introduction: the treatment of the intestinal obstruction depends on a premature diagnosis, a skilful and opportune- treatment handling. Objective: characterizing the behavior of the morbimortality for intestinal occlusion at Cienfuegos pro...

DOAJ Open Access (DOAJ)

Berberine protects against hypoxia-induced intestinal injury through modulation of gut microbiota and bile acid metabolism

Hao Zhang, Hao Zhang, Hao Zhang, Penghui Ye et al. • Frontiers in Immunology (2026)

BackgroundHigh-altitude hypoxia disrupts intestinal homeostasis by impairing the epithelial barrier, triggering inflammation, and promoting microbial translocation. Berberine (BER), a natural isoquinoline alkaloid with antimicrobial and ant...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2026.1784245

The influence of frailty syndrome on medication adherence among elderly patients with hypertension

Jankowska-Polańska B, Dudek K, Szymanska-Chabowska A, Uchmanowicz I • Clinical Interventions in Aging (2016)

Beata Jankowska-Polańska,1 Krzysztof Dudek,2 Anna Szymanska-Chabowska,3 Izabella Uchmanowicz1 1Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 2Department of Logistic and Transport Systems, Faculty of ...

DOAJ Open Access (DOAJ)

Spatiotemporal analysis of hospitalizations, mortality and access to intravenous thrombolysis for ischemic stroke in Southern Brazil

Samile Bonfim, Miyoko Massago, Vinicius Lopes Giacomin, Matheus Henrique Arruda Beltrame et al. • BMC Public Health (2026)

Abstract Background Globally, stroke is a leading cause of mortality and disability, affecting approximately 15 million people annually. This study aimed to analyze hospitalizations, deaths, and thrombolysis for ischemic stroke in Southern ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12889-026-27097-7

Analysing criteria for price and reimbursement of orphan drugs in Spain

Xavier Badia, Alicia Gil, José Luis Poveda-Andrés, John Shepherd et al. • Farmacia Hospitalaria (2019)

Objective: There are differences between countries regarding data requirements for orphan drug evaluation and it is also unknown which criteria might determine the price and reimbursement decision. This study aimed to identify the key c...

DOAJ Open Access (DOAJ) DOI: 10.7399/fh.11147

The Protective Effect of Sulforaphane against Oxidative Stress through Activation of NRF2/ARE Pathway in Human Granulosa Cells

Sahar Esfandyari, Ashraf Aleyasin, Zahra Noroozi, Maryam Taheri et al. • Cell Journal (2021)

Objective: Sulforaphane (SFN) is a natural free radical scavenger that can reduce oxidative stress (OS) through mediating nuclear factor (erythroid-derived 2)-like 2 (NF-E2-related factor 2 or NRF2)/antioxidant response element (ARE) signal...

DOAJ Open Access (DOAJ) DOI: 10.22074/cellj.2021.7393

The Emergence of AI-Based Wearable Sensors for Digital Health Technology: A Review

Shaghayegh Shajari, Kirankumar Kuruvinashetti, Amin Komeili, Uttandaraman Sundararaj • Sensors (2023)

Disease diagnosis and monitoring using conventional healthcare services is typically expensive and has limited accuracy. Wearable health technology based on flexible electronics has gained tremendous attention in recent years for monitoring...

OPENALEX cc-by DOI: https://doi.org/10.3390/s23239498 PMC: 10708748

Methods for Population-Adjusted Indirect Comparisons in Health Technology Appraisal

David Phillippo, Anthony E. Ades, Sofia Dias, Stephen Palmer et al. • Medical Decision Making (2017)

Standard methods for indirect comparisons and network meta-analysis are based on aggregate data, with the key assumption that there is no difference between the trials in the distribution of effect-modifying variables. Methods which relax t...

OPENALEX cc-by DOI: https://doi.org/10.1177/0272989x17725740 PMC: 5774635

Evaluation of Blood-Based Antibody Rapid Testing for HIV Early Therapy: A Meta-Analysis of the Evidence

Xiaojie Huang, Xinchao Liu, Jieqing Chen, Yugang Bao et al. • Frontiers in Immunology (2018)

BackgroundWestern blot (WB) assay is considered the gold standard test for HIV infection confirmation. However, it requires technical expertise and is quite time-consuming. WHO recommends blood-based rapid diagnosis to achieve same-day test...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2018.01458

Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using <i>Lactiplantibacillus plantarum</i> TY-Y10

Shaoqi Shi, Xiaoxia Li, Feng Zhang, Zhengqiang Jiang et al. • Foods (2024)

Oxidative stress is closely linked to aging. Probiotics, whether viable or heat-inactivated, have shown antioxidant properties; however, their effect and mechanism of action in reducing oxidative stress during aging remains underexplored. T...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods13223618

Barriers and facilitators of retention in care after cervical cancer screening: patients’ and healthcare providers’ perspectives

Judith Owokuhaisa, Eleanor Turyakira, Frank Ssedyabane, Deusdedit Tusubira et al. • BMC Women's Health (2024)

Abstract Background Cervical cancer continues to threaten women’s health, especially in low-resource settings. Regular follow-up after screening and treatment is an effective strategy for monitoring treatment outcomes. Consequently, underst...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12905-024-03343-1

Design and Optimization of Trastuzumab-Functionalized Nanolipid Carriers for Targeted Capecitabine Delivery: Anti-Cancer Effectiveness Evaluation in MCF-7 and SKBR3 Cells

Das S, Satapathy BS, Pattnaik G, Pattanaik S et al. • International Journal of Nanomedicine (2025)

Shubhashree Das,1 Bhabani Sankar Satapathy,2 Gurudutta Pattnaik,1 Sovan Pattanaik,3 Yahya Alhamhoom,4 Mohamed Rahamathulla,4 Mohammed Muqtader Ahmed,5 Ismail Pasha6 1Department of Pharmaceutics, School of Pharmacy and Life Sciences, Centuri...

DOAJ Open Access (DOAJ)

Comparative Study for Selective Lithium Recovery via Chemical Transformations during Incineration and Dynamic Pyrolysis of EV Li-Ion Batteries

Srija Balachandran, Kerstin Forsberg, Tom Lemaître, Nathália Vieceli et al. • Metals (2021)

Selective leaching of Li from spent LIBs thermally pretreated by pyrolysis and incineration between 400 and 700 °C for 30, 60, and 90 min followed by water leaching at high temperature and high L/S ratio was examined. During the thermal pre...

DOAJ Open Access (DOAJ) DOI: 10.3390/met11081240