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Study on Three Sarcocapnos Species as Potential Sources of Bioactive Compounds: Relation between Phenolic Content and Bioactivity by Multivariate Analysis

María del Pilar Fernández-Poyatos, Gökhan Zengin, Carlos Salazar-Mendías, Antonio Ruiz-Medina et al. • Journal of Analytical Methods in Chemistry (2020)

In this work, we report the phenolic composition and bioactivity of the aerial parts of three species of Sarcocapnos (S. enneaphylla, S. pulcherrima, and S. saetabensis) to study their potential as sources of bioactive compounds to revalori...

DOAJ Open Access (DOAJ) DOI: 10.1155/2020/8885169

Fixed field alternating gradient accelerator with small orbit shift and tune excursion

Suzanne L. Sheehy, Ken J. Peach, Holger Witte, David J. Kelliher et al. • Physical Review Special Topics. Accelerators and Beams (2010)

A new design principle of a nonscaling fixed field alternating gradient accelerator is proposed. It is based on optics that produce approximate scaling properties. A large field index k is chosen to squeeze the orbit shift as much as possib...

DOAJ Open Access (DOAJ) DOI: 10.1103/PhysRevSTAB.13.040101

Children’s memory “in the wild”: examining the temporal organization of free recall from a week-long camp at a local zoo

Thanujeni Pathman, Lina Deker, Puneet Kaur Parmar, Mark Christopher Adkins et al. • Cognitive Research (2023)

Abstract Free-recall paradigms have greatly influenced our understanding of memory. The majority of this research involves laboratory-based events (e.g., word lists) that are studied and tested within minutes. This literature shows that adu...

DOAJ Open Access (DOAJ) DOI: 10.1186/s41235-022-00452-z

Curcumin Inhibits Growth of Human NCI-H292 Lung Squamous Cell Carcinoma Cells by Increasing FOXA2 Expression

Lingling Tang, Jinjin Liu, Linyun Zhu, Qingge Chen et al. • Frontiers in Pharmacology (2018)

Lung squamous cell carcinoma (LSCC) is a common histological lung cancer subtype, but unlike lung adenocarcinoma, limited therapeutic options are available for treatment. Curcumin, a natural compound, may have anticancer effects in various ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2018.00060

Celiac artery in New Zealand rabbit: anatomical study of its origin and arrangement for experimental research and surgical practice Artéria celíaca em coelhos Nova Zelândia: estudo anatômico de sua origem e arranjo para a pesquisa experimental e a prática cirúrgica

Marcelo Abidu-Figueiredo, Bárbara Xavier-Silva, Themis M. Cardinot, Márcio A. Babinski et al. • Pesquisa Veterinária Brasileira (2008)

Rabbits have been used as an experimental model in many diseases and for the study of toxicology, pharmacology and surgery in many universities. However, some aspects of their macro anatomy need a more detailed description, especially the a...

DOAJ Open Access (DOAJ) DOI: 10.1590/S0100-736X2008000500002

In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity

Andre Luis Dias Araujo Mazzari, Mariella Guimarães Lacerda, Flora Aparecida Milton, Flora Aparecida Milton et al. • Frontiers in Pharmacology (2022)

Many medicinal plants species from European -such as Artemisia absinthium, Equisetum arvense, Lamium album, Malva sylvestris, Morus nigra, Passiflora incarnata, Frangula purshiana, and Salix alba- as well as Latin American traditions -such ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2022.826395

Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli

Yasushi Hirasawa, Aiko Muramatsu, Yoshio Suzuki, Tadashi Nagamatsu • Journal of Pharmacological Sciences (2006)

To elucidate the involvement of cyclooxygenase (COX) in degradation of aggregated protein in diabetic glomeruli, we used streptozotocin (STZ)-induced diabetic mice and aggregated bovine serum albumin (a-BSA) as a model protein. There was a ...

DOAJ Open Access (DOAJ) DOI: 10.1254/jphs.FPJ06010X

The Utilization of Plant-Material-Loaded Vesicular Drug Delivery Systems in the Management of Pulmonary Diseases

Bongani Sannyboy Lukhele, Kokoette Bassey, Bwalya Angel Witika • Current Issues in Molecular Biology (2023)

Medicinal plants have been utilized to treat a variety of conditions on account of the bioactive properties that they contain. Most bioactive constituents from plants are of limited effectiveness, due to poor solubility, limited permeabilit...

DOAJ Open Access (DOAJ) DOI: 10.3390/cimb45120624

Efficacy, safety, and quality of life 4 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A in the phase 3 GENEr8-1 trial

Andrew D. Leavitt, Johnny Mahlangu, Priyanka Raheja, Emily Symington et al. • Research and Practice in Thrombosis and Haemostasis (2024)

Background: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection. Objectives: Determine valoctocogene roxaparvovec du...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rpth.2024.102615

Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm

Hee-Sung Chae, Sun Young Kim, Pisey Pel, Jungmoo Huh et al. • Molecules (2020)

Cough and phlegm frequently occur in respiratory diseases like upper respiratory tract infections, acute bronchitis, and chronic obstructive pulmonary diseases. To relieve these symptoms and diseases, various ingredients are being used desp...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules25133064

Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases

Li Tao, Xiaomeng Ren, Wenhui Zhai, Zheng Chen • Molecules (2022)

Non-canonical nuclear factor kappa B (NF-κB) signaling pathway regulates many physiological and pathological processes, including liver homeostasis and diseases. Recent studies demonstrate that non-canonical NF-κB signaling pathway plays an...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules27134275

Prodigiosin as an Algicidal Agent: Inhibition of Pigment Accumulation and Photosynthetic Efficiency of Cyanobacteria Involved in Algal Blooms

Chaobo Zhang, Chengshuai Xu, Zhenxia Zhu, Xiu Zhang et al. • Microorganisms (2025)

Eutrophication facilitates the proliferation of cyanobacteria, ultimately leading to the formation of harmful cyanobacterial blooms. Prodigiosin, known for its algicidal properties, presents significant potential for application in water po...

DOAJ Open Access (DOAJ) DOI: 10.3390/microorganisms13112569

Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress

Haruka Furuta, Mari Yamada, Takuya Nagashima, Shuichi Matsuda et al. • Frontiers in Pharmacology (2023)

Tendinopathy, a degenerative disease, is characterized by pain, loss of tendon strength, or rupture. Previous studies have identified multiple risk factors for tendinopathy, including aging and fluoroquinolone use; however, its therapeutic ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2023.1137952

Perspective on the Therapeutics of Anti-Snake Venom

Isabel Gómez-Betancur, Vedanjali Gogineni, Andrea Salazar-Ospina, Francisco León • Molecules (2019)

Snakebite envenomation is a life-threatening disease that was recently re-included as a neglected tropical disease (NTD), affecting millions of people in tropical and subtropical areas of the world. Improvement in the therapeutic approaches...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules24183276

Role of pyroptosis in spinal cord injury and its therapeutic implications

Abdullah Al Mamun, Yanqing Wu, Ilma Monalisa, Chang Jia et al. • Journal of Advanced Research (2021)

Background: Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosi...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jare.2020.08.004

Modified Riceberry rice extract suppresses melanogenesis-associated cell differentiation through tyrosinase-mediated MITF downregulation on B16 cells and in vivo zebrafish embryos

Teerapat Rodboon, Sasithorn Sirilun, Seiji Okada, Ryusho Kariya et al. • Research in Pharmaceutical Sciences (2020)

Background and purpose: Excessive melanin production caused by overactive tyrosinase (TYR) enzyme results in several dermatological problems. The TYR inhibitor, derived from metabolite changes during fermentation, has been well recognized f...

DOAJ Open Access (DOAJ) DOI: 10.4103/1735-5362.297852