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Biosynthesis of rare 20(R)-protopanaxadiol/protopanaxatriol type ginsenosides through Escherichia coli engineered with uridine diphosphate glycosyltransferase genes

Lu Yu, Yuan Chen, Jie Shi, Rufeng Wang et al. • Journal of Ginseng Research (2019)

Background: Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jgr.2017.09.005

Mechanistic insights into TAM-mediated OMP assembly in Gram-negative bacteria

Qinghua Luo, Xintan Dong, Zhaxi Zerang, Yujiao Chen et al. • Cell Reports (2026)

Summary: The β-barrel assembly machinery (BAM) is essential for outer membrane protein (OMP) biogenesis in Gram-negative bacteria and represents a validated target for antibiotic development. Its evolutionary relative, the translocation and...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.celrep.2026.117733

Roles of Rap1 signaling in tumor cell migration and invasion

Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z. Ring et al. • Cancer Biology & Medicine (2017)

Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Th...

DOAJ Open Access (DOAJ) DOI: 10.20892/j.issn.2095-3941.2016.0086

FAM83A as a Potential Biological Marker Is Regulated by miR-206 to Promote Cervical Cancer Progression Through PI3K/AKT/mTOR Pathway

Li Rong, Haiyu Li, Zhaodong Li, Jing Ouyang et al. • Frontiers in Medicine (2020)

Background and Objective: Chemotherapy and radiotherapy are effective treatment options for cervical cancer (CC), but their efficacy is limited by short survival rate of about 5 years particularly for advance stage CC. Bioinformatics analys...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2020.608441

CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase

Jing Yang, Pengfei Li, Pengfei Li, Pengfei Li et al. • Frontiers in Immunology (2022)

ObjectiveExtranodal natural killer/T cell lymphoma (NKTCL) is an aggressive EBV-related lymphoma, originating from NK cells or T cells. Previous study demonstrated that CD56 negative NKTCL should be recognized as a distinct subtype. In this...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2022.829366

Multi-Cohort Transcriptomics Combined with Mendelian Randomization Identifies PPARGC1A, NAAA and GIPC2 as NLRP3 Inflammasome-Related Key Genes in Ulcerative Colitis

Cheng J, Huang Y • Journal of Inflammation Research (2026)

Jian Cheng, Yangfeng Huang Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, School of Medicine,University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of ChinaCorrespond...

DOAJ Open Access (DOAJ)

CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia

Weiwei Liu, Yan Wang, Zhimei Qiu, Ranzun Zhao et al. • PeerJ (2020)

Background The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia. Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are involved in the regulation of physiological and pathophy...

DOAJ Open Access (DOAJ) DOI: 10.7717/peerj.9796

Sequential Portal Vein Embolization and Percutaneous Radiofrequency Ablation for Future Liver Remnant Growth: A Minimally Invasive Alternative to ALPPS Stage-1 in Treatment of Hepatocellular Carcinoma

Qiang Wang, Qiang Wang, Yujun Ji, Torkel B. Brismar et al. • Frontiers in Surgery (2021)

Background: To evaluate the feasibility and efficacy of sequential portal vein embolization (PVE) and radiofrequency ablation (RFA) (PVE+RFA) as a minimally invasive variant for associating liver partition and portal vein ligation for stage...

DOAJ Open Access (DOAJ) DOI: 10.3389/fsurg.2021.741352

Misalignment-modulated magnetoelastic transduction for field-tunable stiffness in chain-like magnetorheological elastomers: a Green-function-weighted traction-transfer framework

ShuLei Sun, Kesheng Zhang, Shunke Zhang, Ning Tian et al. • Materials Research Express (2026)

Magnetorheological elastomers (MREs) are field-responsive composites whose stiffness can be tuned by a magnetic field. In chain-like MREs, strong local magnetic interactions and Maxwell tractions do not necessarily translate into a measurab...

DOAJ Open Access (DOAJ) DOI: 10.1088/2053-1591/aeb47a

Data-Driven Cooperative Control Model of Shearer-Scraper Conveyor Based on Rough Set Theory

Shuanfeng Zhao, Jiaojiao Zhao, Jiaojiao Zhao, Zhengxiong Lu et al. • Frontiers in Energy Research (2022)

The cooperative control of shearer and scraper conveyors is the prerequisite for the realization of intelligent comprehensive mining equipment and unmanned comprehensive mining workings. However, because of the harsh working face environmen...

DOAJ Open Access (DOAJ) DOI: 10.3389/fenrg.2022.811648

Grain boundary and texture evolution of TiB/Ti–2Al–6Sn titanium matrix composite under electroshocking treatment

Yaya Wu, Yan Wen, Anan Guo, Jian Zhou et al. • Journal of Materials Research and Technology (2023)

This work used electroshocking treatment (EST) plus external loading to regulate the microstructure of titanium matrix composites (TMCs). The external loading was 0.3 MPa. After EST plus external loading with 0.3 MPa, the α was reduced to 2...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jmrt.2023.10.177

3D Printing parameter optimisation combined with heat treatment for achieving high density and enhanced performance in refractory high-entropy alloys

Deyu Jiang, Miao Luo, Changxi Liu, Yashuo Zhang et al. • Virtual and Physical Prototyping (2025)

In this study, a Ti1.5Nb1Ta0.5Zr1Mo0.5 (TNTZM) high-entropy alloy was fabricated using laser powder bed fusion (LPBF). By integrating 63 sets of parameter trials with machine learning (ML) models, an optimised process window was identified,...

DOAJ Open Access (DOAJ) DOI: 10.1080/17452759.2025.2524524

The Biomechanical Characteristics of Swallowing in Tracheostomized Patients with Aspiration following Acquired Brain Injury: A Cross-Sectional Study

Xiao-Xiao Han, Jia Qiao, Zhan-Ao Meng, Dong-Mei Pan et al. • Brain Sciences (2023)

Objectives: Investigate the biomechanical characteristics in tracheostomized patients with aspiration following acquired brain injury (ABI) and further explore the relationship between the biomechanical characteristics and aspiration. Metho...

DOAJ Open Access (DOAJ) DOI: 10.3390/brainsci13010091

Research on 4WS Agricultural Machine Path Tracking Algorithm Based on Fuzzy Control Pure Tracking Model

Chengliang Zhang, Guanlei Gao, Chunzhao Zhao, Lei Li et al. • Machines (2022)

This paper presents a path tracking algorithm based on a fuzzy control pure tracking model for autonomous navigation of 4WS agricultural machines. The aim of this research is to implement path tracking for unmanned 4WS agricultural machiner...

DOAJ Open Access (DOAJ) DOI: 10.3390/machines10070597

Effect of Tunnel Ventilation on Hydrogen Dispersion From Leaks in Hydrogen Fuel Cell Trucks

Limin Geng, Shiyu Shan, Zongxue Yan, Nan Gao et al. • Energy Science & Engineering (2026)

ABSTRACT The widespread adoption of hydrogen fuel cell trucks (HFCTs) depends on addressing hydrogen safety concerns, particularly in confined spaces like tunnels, where effective ventilation is crucial to prevent accumulation during leaks....

DOAJ Open Access (DOAJ) DOI: 10.1002/ese3.70547

Flexural Behaviour of Corroded RC Beams Strengthened with CFRCM: Refined Modelling, Parametric Analysis, and Design Assessment

Chaoqun Zeng, Jing-Pu Tang, Liangliang Wei, Miaochang Zhu et al. • Buildings (2026)

Reinforced concrete (RC) beams strengthened with carbon-fabric-reinforced cementitious matrix (CFRCM) systems have shown potential for restoring flexural performance, yet their effectiveness under different corrosion levels remains insuffic...

DOAJ Open Access (DOAJ) DOI: 10.3390/buildings16020377

A Proactive Collision Avoidance Model for Connected and Autonomous Vehicles in Mixed Traffic Flow

Guojing Hu, Kun Li, Weike Lu, Ouchan Chen et al. • World Electric Vehicle Journal (2025)

Collision avoidance between vehicles is a great challenge, especially in the context of mixed driving of connected and autonomous vehicles (CAVs) and human-driven vehicles (HVs). Advances in automation and connectivity technologies provide ...

DOAJ Open Access (DOAJ) DOI: 10.3390/wevj16070394

Hybrid Dynamic Traffic Model for Freeway Flow Analysis Using a Switched Reduced-Order Unknown-Input State Observer

Yuqi Guo, Bin Li, Matthew Daniel Christie, Zongzhi Li et al. • Sensors (2020)

This paper introduces a new methodology for reconstructing vehicle densities of freeway segments by utilizing the limited data collected by traffic-counting sensors and developing a macroscopic traffic stream model formulated as a switched ...

DOAJ Open Access (DOAJ) DOI: 10.3390/s20061609