Academic Articles & Research Papers

Building Theories in Software Engineering

Software engineering, the software process and their support

Computers are being applied more and more widely, penetrating ever deeper into the very fabric of society. Mankind is becoming increasingly dependent on the availability of software and its continuing validity. To achieve this consistently ...

Rethinking Productivity in Software Engineering

This open access book collects the wisdom of the 2017 Dagstuhl seminar on productivity in software engineering. It includes chapters on definitions and core concepts related to guidelines for measuring productivity in specific contexts, bes...

A survey of controlled experiments in software engineering

The classical method for identifying cause-effect relationships is to conduct controlled experiments. This paper reports upon the present state of how controlled experiments in software engineering are conducted and the extent to which rele...

Applications of Ontologies in Software Engineering

The emerging field of semantic web technologies promises new stimulus for Software Engineering research. However, since the underlying concepts of the semantic web have a long tradition in the knowledge engineering field, it is sometimes ha...

Software Engineering with Reusable Components

Alterations in Hip and Knee Joint Contact Force Waveforms and Orientation Induced by Gait Modifications: A Case Study

Introduction & Purpose Idiopathic torsional deformities of lower limb bones can affect a patient’s gait pattern and joint health, while their cause remains unidentified (Koller et al., 2026). Abnormal joint loadings and the progression of ...

Pengembangan Sistem Informasi DataRawat Berbasis Web

Rekam medis adalah catatan kesehatan pasien berdasarkan hasil pemeriksaan, pengobatan, tindakan, dan layanan yang telah diberikan kepada pasien. Beberapa instansi medis telah menggunakan sistem rekam medis elektronik atau Electronic Medical...

Cyberattacks on Miniature Brain Implants to Disrupt Spontaneous Neural Signaling

Brain-Computer Interfaces (BCI) arose as systems that merge computing systems with the human brain to facilitate recording, stimulation, and inhibition of neural activity. Over the years, the development of BCI technologies has shifted towa...

BP Neural Network–Based Kalman Filtering Method Under Multiple Cyberattacks

This paper proposes a Kalman-gain-driven neural Kalman filtering (KF) defense framework, termed KFDBP, for secure state estimation in cyber–physical systems (CPSs) under denial-of-service (DoS), spoofing, and replay attacks. Unlike end-to-e...

Volume Segmentation of Liver and Liver Tumor with Fusion of Multi-Branch Features

The overcomplete convolutional structure for biological images and volume segmentation is an excellent solution to the problem in which traditional codec methods cannot accurately segment the boundary regions. Although such methods perform ...

Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics

Recent studies in cancer diagnostics have identified microRNAs (miRNAs) as promising cancer biomarkers. Single nucleotide polymorphisms (SNPs) in miRNA binding sites, seed regions, and coding sequences can help predict breast cancer risk, a...

Progressive suppression of regulated cell death defines terminal macrophage states in liver cirrhosis

Background Macrophages are central regulators of liver immunity and fibrosis; Recent single-cell studies have characterized macrophage heterogeneity in cirrhosis; however, how regulated cell death programs shape their functional transitions...

Post-Fire Abundance Trajectories of Bird Species and Functional Groups Within an Atlantic–Mediterranean Ecotone

The Atlantic–Mediterranean ecotone of northwestern Iberia is one of the most fire-prone regions in Europe, yet post-fire avian dynamics there remain poorly documented. To characterise short- to mid-term post-fire avian trajectories in this ...

Genetic analysis of suicide: a sample study in Tuscany (Central Italy)

Many studies have examined the genetic contribution to suicide. However, data on suicide in the Italian population are scarce. We therefore aimed to address this gap by investigating a cohort of 111 Italians for whom a verdict of suicide ha...

Generation of human induced pluripotent stem cell line MHHi040-A from a female Fabry disease patient carrying c.644A>G missense mutation

Fabry disease (FD) is an X-linked, monogenic lysosomal storage disorder, caused by mutations in the GLA gene. GLA encodes the lysosomal hydrolase alpha-galactosidase A and enzyme deficiency leads to accumulation of its substrate globotriaos...

The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis

Abstract The tumor microenvironment in brain metastases is characterized by high myeloid cell content associated with immune suppressive and cancer‐permissive functions. Moreover, brain metastases induce the recruitment of lymphocytes. Desp...

A Comparative Analysis of the Chloroplast Genomes of Four Polygonum Medicinal Plants

Polygonum is a generalized genus of the Polygonaceae family that includes various herbaceous plants. In order to provide aid in understanding the evolutionary and phylogenetic relationship in Polygonum at the chloroplast (cp) genome-scale l...

Epigenetic alterations in mesenchymal stem cells by osteosarcoma-derived extracellular vesicles

Extracellular vesicles (EVs) are central to intercellular communication and play an important role in cancer progression and development. Osteosarcoma (OS) is an aggressive bone tumour, characterized by the presence of malignant mesenchymal...

Functional annotation of the human retinal pigment epithelium transcriptome

Abstract Background To determine level, variability and functional annotation of gene expression of the human retinal pigment epithelium (RPE), the key tissue involved in retinal diseases like age-related macular degeneration and retinitis ...