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Dichloroacetate as a metabolic modulator of heart mitochondrial proteome under conditions of reduced oxygen utilization

Natalia Andelova, Iveta Waczulikova, Lukas Kunstek, Ivan Talian et al. • Scientific Reports (2022)

Abstract Myocardial compensatory mechanisms stimulated by reduced oxygen utilization caused by streptozotocin-induced diabetes mellitus (DM) and treated with dichloroacetate (DCA) are presumably associated with the regulation of mitochondri...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-022-20696-5

Key Variables for Effective eHealth Designs for Individuals With and Without Mental Health Disorders: 2^12-4 Fractional Factorial Experiment

Rotondi, Armando J, Grady, Jonathan, Hanusa, Barbara H, Haas, Gretchen L et al. • Journal of Medical Internet Research (2021)

BackgroundeHealth applications not only offer the potential to increase service convenience and responsiveness but also expand the ability to tailor services to improve relevance, engagement, and use. To achieve these goals, it is critical ...

DOAJ Open Access (DOAJ) DOI: 10.2196/23137

Hackathons as Stepping Stones in Health Care Innovation: Case Study With Systematic Recommendations

Poncette, Akira-Sebastian, Rojas, Pablo-David, Hofferbert, Joscha, Valera Sosa, Alvaro et al. • Journal of Medical Internet Research (2020)

BackgroundUntil recently, developing health technologies was time-consuming and expensive, and often involved patients, doctors, and other health care professionals only as passive recipients of the end product. So far, users have been mini...

DOAJ Open Access (DOAJ) DOI: 10.2196/17004

Association between social health status and health-related quality of life among community-dwelling elderly in Zhejiang

Jieming Lu, Zhebin Yu, Xiaocong Zhang, Mengyin Wu et al. • Health and Quality of Life Outcomes (2020)

Abstract Background Population aging is an inevitable trend and previous studies have showed the relationship between social health related factors and health-related quality of life (HR-QOL) in the elderly. The objective of this study is t...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12955-020-01358-4

Wrist movements induce torque and lever force in the scaphoid: an ex vivo study

Jochen Erhart, Ewald Unger, Philip Schefzig, Peter Varga et al. • Journal of Orthopaedic Surgery and Research (2020)

Abstract Purpose We hypothesised that intercarpal K-wire fixation of adjacent carpal bones would reduce torque and lever force within a fractured scaphoid bone. Methods In eight cadaver wrists, a scaphoid osteotomy was stabilised using a lo...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13018-020-01897-y

Challenges and conditions for successfully implementing and adopting the telematics infrastructure in German outpatient healthcare: A qualitative study applying the NASSS framework

Kim Nordmann, Stefanie Sauter, Marie-Christin Redlich, Patricia Möbius-Lerch et al. • Digital Health (2024)

Background Germany's healthcare system provides high-quality, universal health coverage to almost all residents. However, a major challenge lies in the strong separation of healthcare structures, which hinders efficient interprofessional an...

DOAJ Open Access (DOAJ) DOI: 10.1177/20552076241259855

Injury death certificates without specification of the circumstances leading to the fatal injury – the Norwegian Cause of Death Registry 2005–2014

Christian Lycke Ellingsen, Marta Ebbing, G. Cecilie Alfsen, Stein Emil Vollset • Population Health Metrics (2018)

Abstract Background For injury deaths, the underlying cause of death is defined as the circumstances leading to the injury. When this information is missing, the ICD-10 code X59 (Exposure to unspecified factor) is used. Lack of knowledge of...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12963-018-0176-2

Optimal@NRW: optimized acute care of nursing home residents using an intersectoral telemedical cooperation network — study protocol for a stepped-wedge trial

David Brücken, Jenny Unterkofler, Sophie Pauge, Jonas Bienzeisler et al. • Trials (2022)

Abstract Background Increasing life expectancy is associated with a growing number of people living in nursing homes, while the availability of outpatient medical care, especially from family doctors, is stagnating in this sector. Consequen...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13063-022-06613-1

Caring for Computers: The Hidden Work of Clinical Nurses during the Introduction of Health Information Systems in a Teaching Hospital in Taiwan

Feng-Tzu Huang • Nursing Reports (2021)

Implementing health information systems for enhancing patient care and management occurs worldwide. Discovering how nurses, as important system end-users, experience technology-reliant clinical practice involved focus groups (n = 25) and in...

DOAJ Open Access (DOAJ) DOI: 10.3390/nursrep11010011

Dopamine transporter binding in symptomatic controls and healthy volunteers: Considerations for neuroimaging trials

Emma A. Honkanen, Mikael Eklund, Simo Nuuttila, Tommi Noponen et al. • NeuroImage: Clinical (2021)

Objective: To evaluate possible differences between brain dopamine transporter (DAT) binding in a group of symptomatic parkinsonism patients without dopaminergic degeneration and healthy individuals. Background: Dopaminergic neuroimaging st...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2021.102807

Artificial intelligence-driven anthropometric assessment for young children: evaluating the accuracy and practicality of a digital image-based length and weight prediction tool

Fabian Yap, Daniel Chan, Mei Chien Chua, Matthew Hadimaja et al. • BMJ Health & Care Informatics (2025)

Background Monitoring early childhood growth is vital, as growth faltering could indicate nutritional or health issues requiring prompt intervention. Our study’s aim was to assess the performance of a length-weight artificial intelligence (...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjhci-2025-101540

Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol

Siân Lowri Griffiths, Graham K Murray, Yanakan Logeswaran, John Ainsworth et al. • JMIR Research Protocols (2024)

BackgroundEarly intervention in psychosis (EIP) services are nationally mandated in England to provide multidisciplinary care to people experiencing first-episode psychosis, which disproportionately affects deprived and ethnic minority yout...

DOAJ Open Access (DOAJ) DOI: 10.2196/50177

From Connectivity to Controllability: Unraveling the Brain Biomarkers of Major Depressive Disorder

Chunyu Pan, Ying Ma, Lifei Wang, Yan Zhang et al. • Brain Sciences (2024)

Major Depressive Disorder (MDD) is a significant neurological condition associated with aberrations in brain functional networks. Traditional studies have predominantly analyzed these from a network topology perspective. However, given the ...

DOAJ Open Access (DOAJ) DOI: 10.3390/brainsci14050509

Modulation of frontal gamma oscillations improves working memory in schizophrenia

Fiza Singh, I-Wei Shu, Sheng-Hsiou Hsu, Peter Link et al. • NeuroImage: Clinical (2020)

Schizophrenia is a debilitating mental disorder that is associated with cognitive deficits. Impairments in cognition occur early in the course of illness and are associated with poor functional outcome, but have been difficult to treat with...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2020.102339

Trends in Proportion of Delirium Among Older Emergency Department Patients in South Korea, 2017–2022

Jeongmin Moon, Seonji Kim, Daesung Lim, Ho Kyung Sung et al. • Western Journal of Emergency Medicine (2025)

Introduction: Delirium is a critical neuropsychiatric condition that surged among older adults during the coronavirus disease 2019 (COVID-19) pandemic, likely due to social isolation resulting from distancing measures. In this study we exam...

DOAJ Open Access (DOAJ) DOI: 10.5811/westjem.41507

A Focus on Simulation in Medical Informatics

James G. Anderson • Journal of the American Medical Informatics Association (2002)

This special issue of JAMIA addresses simulation, a methodology that holds great promise for the advancement of information technology in health care. Simulation has been termed a third domain, complementing both natural language and mathem...

OPENALEX Open Access DOI: https://doi.org/10.1197/jamia.m1167 PMC: 346642

Effects of individualized rTMS on functional connectivity related to the default mode network and frontal-parietal network in major depressive disorder: exploratory analysis of a randomized controlled trial

Jing Jin, Yun Wang, Sixiang Liang, Qingchen Fan et al. • NeuroImage: Clinical (2025)

Objective: Repetitive transcranial magnetic stimulation (rTMS) has been shown to alleviate depressive and anxiety symptoms in patients with major depressive disorder (MDD), typically by targeting the dorsolateral (DLPFC) or dorsomedial pref...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2025.103902