Academic Articles & Research Papers

Emodin inhibits Newcastle disease virus replication via regulating the phosphorylation levels of eEF2K/eEF2 and targeting viral N protein to reduce viral protein production

Newcastle disease (ND) caused by Newcastle disease virus (NDV) infection is a highly contagious avian disease that causes substantial threat to the global poultry industry. Emodin (EMO), a member of the free anthraquinone compounds derived ...

De novo SCN1A missense variant in a patient with Parkinson’s disease

BackgroundVariants in a gene encoding sodium voltage-gated channel alpha subunit 1 (SCN1A) are known to cause a broad clinical spectrum of epilepsy and associated features, including Dravet syndrome (MIM 607208), non-Dravet developmental an...

Assessing Phase-Locked Repetitive Transcranial Magnetic Stimulation for Treatment of Parkinson’s and Essential Tremor

Cracking rare disorders: a new minimally invasive RNA-seq protocol

Abstract RNA sequencing (RNA-seq) has become key to complementing exome and genome sequencing for variant interpretation. We present a minimally invasive RNA-seq protocol using short-term cultured peripheral blood mononuclear cells (PBMCs) ...

Inhibition of Citrus Huanglongbing Disease by <i>Paenibacillus polymyx</i> KN-03 and Analysis with Transcriptome and Microflora

Soil drench treatment using Paenibacillus polymyxa strain KN-03 was applied to citrus plants infected with Candidatus Liberibacter asiaticus (CLas). The infection status was assessed using PCR and a real-time quantitative PCR detection syst...

Prevalence and factors associated with continual opioid use among patients attending methadone clinic at Mwananyamala Hospital, Dar Es Salaam, Tanzania

Trends of continual drug use while under treatment have been reported worldwide. This paper assesses opioid use among patients receiving treatment in a methadone clinic for opioid addiction. A total of 126 urine samples were analyzed using ...

UPLC-MS/MS Metabolomics Reveals Babao Dan’s Mechanisms in MASH Treatment with Integrating Network Pharmacology and Molecular Docking

Background: Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive disease that easily develops into cirrhosis and hepatocellular carcinoma, but its pathogenesis is not clear, and most therapeutic drugs have obvious limita...

Effect of Theaflavins-Soy Protein Isolate Complex Coating on the Quality of Lentinus edodes

In order to clarify the preservation effect of theaflavins-soy protein isolate complex coating on Lentinus edodes, a TFs-SPI complex coating agent was prepared by mixing theaflavins and soy protein isolate as subjects, and its structure was...

Impact of Ultra-High Pressure Homogenization on the Structural Properties of Egg Yolk Granule

Ultra-high pressure homogenization (UHPH) is a promising method for destabilizing and potentially improving the techno-functionality of the egg yolk granule. This study’s objectives were to determine the impact of pressure level (50, 175 an...

Toxicity of Parasporin-4 and Health Effects of Pro-parasporin-4 Diet in Mice

Parasporin-4 (PS4) is an aerolysin-type β-pore-forming toxin produced by Bacillus thuringiensis strain A1470. It exhibits specific cytotoxicity against human cancer cell lines; therefore, it is expected to be useful for the diagnosis and tr...

Methyl Jasmonate and Zinc Sulfate Induce Secondary Metabolism and Phenolic Acid Biosynthesis in Barley Seedlings

This study aimed to reveal the impact of MeJA and ZnSO4 treatments on the physiological metabolism of barley seedlings and the content of phenolic acid. The results showed that MeJA (100 μM) and ZnSO4 (4 mM) treatments effectively increased...

Consumer Acceptance of Texture-Modified Mackerel Stew Products in Older Adults

Along with concerns regarding societal aging, the dietary requirements of older adults have become a priority. Older adults in Korea experience difficulties consuming animal protein sources as they age. Therefore, this study aimed to develo...

Alleviation effect of glycyrrhetinic acid on zearalenone-induced reproductive toxicity in replacement gilts

IntroductionThis study investigated whether glycyrrhetinic acid (GA) can alleviate the reproductive toxicity of Zearalenone (ZEN) in replacement gilts.MethodsEighty Landrace × Yorkshire gilts were randomly assigned to four dietary groups: c...

Effect of Nano-multi Micronutrients on Agronomic Traits, Nutrient Uptake and Soil Fertility in Pot Trial of Maize (Zea mays L.)

A pot experiment of maize was carried during summer seasons of March–July, 2023 and 2024 at the experimental field of Rashtriya Chemicals and Fertilizers, Mumbai, India, to assess the impact of multi nano micronutrients formulation (NM) on ...

Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α–XBP1 Axis in HepG2 Cells

Emodin, an emerging mycotoxin, is known to be hepatotoxic, but its mechanism remains unclear. We hypothesized that emodin could induce endoplasmic reticulum (ER) stress through the inositol-requiring enzyme 1 alpha (IRE1α)–X-box-binding pro...

Exploring Volatile Profiles and De-Flavoring Strategies for Enhanced Acceptance of Lentil-Based Foods: A Review

Lentils are marketed as dry seeds, fresh sprouts, flours, protein isolates, and concentrates used as ingredients in many traditional and innovative food products, including dairy and meat analogs. Appreciated for their nutritional and healt...

Evaluation of clinical quality improvement interventions: feasibility of an integrated approach

Abstract Background Cardiovascular diseases (CVD) are the largest cause of death and disability in Australia. Australian national guidelines for the primary prevention of CVD recommend that all adults without CVD and aged 45 years or more a...

Cuidados en los equipos profesionales: reflexiones a partir del archivo oral y memoria del Cuartel Borgoño (1977-1989), Santiago de Chile

The purpose of this article is to present some of the considerations that arose following the development of an experience of caregiving for teams of professionals who support, investigate, and collect testimonies on human rights violations...

A review on the recent mechanisms investigation of PFAS electrochemical oxidation degradation: mechanisms, DFT calculation, and pathways

Per- and polyfluoroalkyl substances (PFAS) have drawn public concern recently due to their toxic properties and persistence in the environment, making it urgent to eliminate PFAS from contaminated water. Electrochemical oxidation (EO) has s...

Treatment and Disposal Methods of Concentrate Stream of Seawater Reverse Osmosis- A Review

The exponentially multiplying population of the world demands increasing freshwater resources. Thelimited resources comprising less than 3% of the earth’s water resources are getting polluted at an alarming rate. To deal with this situation...