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Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding

Yong Han, Guobin Xia, Dollada Srisai, Fantao Meng et al. • Nature Communications (2021)

Neuronal signaling has an important role in the regulation of energy expenditure and body weight, however, the underlying mechanisms are incompletely understood. Here, the authors report a AgRP-MC4R-serotonin expressing neuronal circuit tha...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-021-23846-x

Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival

Noela Rodriguez-Losada, Noela Rodriguez-Losada, Rune Wendelbob, M. Carmen Ocaña et al. • Frontiers in Neuroscience (2020)

Emerging scaffold structures made of carbon nanomaterials, such as graphene oxide (GO) have shown efficient bioconjugation with common biomolecules. Previous studies described that GO promotes the differentiation of neural stem cells and ma...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2020.570409

Roles of Rap1 signaling in tumor cell migration and invasion

Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z. Ring et al. • Cancer Biology & Medicine (2017)

Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Th...

DOAJ Open Access (DOAJ) DOI: 10.20892/j.issn.2095-3941.2016.0086

In vivo topology converts competition for cell-matrix adhesion into directional migration

Fernanda Bajanca, Nadège Gouignard, Charlotte Colle, Maddy Parsons et al. • Nature Communications (2019)

Migrating cells encounter multiple signals such as extracellular matrix (ECM) and chemokinetic factors but how these integrate in vivo is unclear. Here, the authors report that overall control of cell-ECM adhesion by Sema3A and Sdf1 can be ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-019-09548-5

Effects of the Brazilian Native Fruit Jaboticaba (<i>Plinia cauliflora</i>) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models

Ligia Soares Lima, Jessyca Sousa de Brito, Marcelo Ribeiro-Alves, Karen Salve Coutinho-Wolino et al. • Foods (2025)

Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14234030

Identification of functional pathways for regenerative bioactivity of selected renal cells

Wei Sha, Timothy Bertram, Deepak Jain, Cory Brouwer et al. • Stem Cell Research & Therapy (2022)

Abstract Background Selected renal cells (SRC) are in Phase II clinical trials as a kidney-sourced, autologous, tubular epithelial cell-enriched cell-based therapy for chronic kidney disease (CKD). In preclinical studies with rodent models ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13287-022-02713-6

Can Bacillus paranthracis cause bacteremia in a T-ALL patient? WGS-based diagnosis

Serap Süzük Yıldız, Ayşegül Polat, Süleyman Yalçın, Mert Emre Ölmez et al. • Journal of Infection in Developing Countries (2025)

Introduction: Most of Bacillus spp. generally avirulent species in healthy patients, but if there is a fragile in the patient, especially their immune system, Bacillus spp. can be an agent for infections. Case Report: In this case, we rep...

DOAJ Open Access (DOAJ) DOI: 10.3855/jidc.20080

Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy

O. A. Gromova, I. Yu. Torshin, A. G. Moiseenok • Фармакоэкономика (2025)

Background. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect ...

DOAJ Open Access (DOAJ) DOI: 10.17749/2070-4909/farmakoekonomika.2024.285

miR-130a-3p Exacerbates Sepsis-Induced Cardiac Dysfunction by Promoting Inflammation and Targeting PDK4

Jinyu Liu, Xiaowei Yuan, Wei Chen, Dongqin Shen • Clinical and Applied Thrombosis/Hemostasis (2026)

Background Sepsis is frequently complicated by systemic inflammatory injury and cardiac dysfunction, which serve as risk factors of adverse clinical outcomes and increased mortality risk. To clarify the function of miR-130a-3p in sepsis dia...

DOAJ Open Access (DOAJ) DOI: 10.1177/10760296261468449

Constraining PERMANOVA and LDM to within-set comparisons by projection improves the efficiency of analyses of matched sets of microbiome data

Zhengyi Zhu, Glen A. Satten, Caroline Mitchell, Yi-Juan Hu • Microbiome (2021)

Abstract Background Matched-set data arise frequently in microbiome studies. For example, we may collect pre- and post-treatment samples from a set of individuals, or use important confounding variables to match data from case participants ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40168-021-01034-9

Molecular docking and mouse modeling suggest CMKLR1 and INSR as targets for improving PCOS phenotypes by minocycline

Mahdie Kian, Elham Hosseini, Tooba Abdizadeh, Taimour Langaee et al. • EXCLI Journal : Experimental and Clinical Sciences (2022)

Polycystic ovary syndrome (PCOS) is the most common cause of women’s infertility. Some inflammatory pathways play a pivotal role in the pathogenesis of PCOS. This study aimed to investigate the possible beneficial effects of minocycline on ...

DOAJ Open Access (DOAJ) DOI: 10.17179/excli2021-4534

Impact of Myocardial Ischemia and Revascularization by Percutaneous Coronary Intervention on Circulating Level of Soluble ST2

Alkhateeb A, Mahmoud HEM, AK M, Hassan MH et al. • Vascular Health and Risk Management (2023)

Areej Alkhateeb,1 Hossam Eldin M Mahmoud,1 Mohammed AK,1 Mohammed H Hassan,2 Abdel Rahim Mahmoud Muddathir,3 Ahmed G Bakry1 1Cardiology Division of Internal Medicine Department, South Valley University Hospital, Faculty of Medicine, South V...

DOAJ Open Access (DOAJ)

NONLINEAR BANK RISK APPETITE UNDER ECONOMIC POLICY UNCERTAINTY: THE ROLE OF REGULATORY QUALITY AND DEPOSIT INSURANCE

Халіл Улла Мохаммад, Мухаммад Кашір, Нур-Уль-Хая Аднан • Фінансово-кредитна діяльність: проблеми теорії та практики (2026)

Economic policy uncertainty has been increasing globally, with consequences for financial sector stability. This paper investigates its influence on the risk-taking behavior of banks. The study examines the functional form of responses of b...

DOAJ Open Access (DOAJ) DOI: 10.55643/fcaptp.1.66.2026.5050

Misalignment-modulated magnetoelastic transduction for field-tunable stiffness in chain-like magnetorheological elastomers: a Green-function-weighted traction-transfer framework

ShuLei Sun, Kesheng Zhang, Shunke Zhang, Ning Tian et al. • Materials Research Express (2026)

Magnetorheological elastomers (MREs) are field-responsive composites whose stiffness can be tuned by a magnetic field. In chain-like MREs, strong local magnetic interactions and Maxwell tractions do not necessarily translate into a measurab...

DOAJ Open Access (DOAJ) DOI: 10.1088/2053-1591/aeb47a

Data-Driven Cooperative Control Model of Shearer-Scraper Conveyor Based on Rough Set Theory

Shuanfeng Zhao, Jiaojiao Zhao, Jiaojiao Zhao, Zhengxiong Lu et al. • Frontiers in Energy Research (2022)

The cooperative control of shearer and scraper conveyors is the prerequisite for the realization of intelligent comprehensive mining equipment and unmanned comprehensive mining workings. However, because of the harsh working face environmen...

DOAJ Open Access (DOAJ) DOI: 10.3389/fenrg.2022.811648

The Biomechanical Characteristics of Swallowing in Tracheostomized Patients with Aspiration following Acquired Brain Injury: A Cross-Sectional Study

Xiao-Xiao Han, Jia Qiao, Zhan-Ao Meng, Dong-Mei Pan et al. • Brain Sciences (2023)

Objectives: Investigate the biomechanical characteristics in tracheostomized patients with aspiration following acquired brain injury (ABI) and further explore the relationship between the biomechanical characteristics and aspiration. Metho...

DOAJ Open Access (DOAJ) DOI: 10.3390/brainsci13010091

Research on 4WS Agricultural Machine Path Tracking Algorithm Based on Fuzzy Control Pure Tracking Model

Chengliang Zhang, Guanlei Gao, Chunzhao Zhao, Lei Li et al. • Machines (2022)

This paper presents a path tracking algorithm based on a fuzzy control pure tracking model for autonomous navigation of 4WS agricultural machines. The aim of this research is to implement path tracking for unmanned 4WS agricultural machiner...

DOAJ Open Access (DOAJ) DOI: 10.3390/machines10070597

A Proactive Collision Avoidance Model for Connected and Autonomous Vehicles in Mixed Traffic Flow

Guojing Hu, Kun Li, Weike Lu, Ouchan Chen et al. • World Electric Vehicle Journal (2025)

Collision avoidance between vehicles is a great challenge, especially in the context of mixed driving of connected and autonomous vehicles (CAVs) and human-driven vehicles (HVs). Advances in automation and connectivity technologies provide ...

DOAJ Open Access (DOAJ) DOI: 10.3390/wevj16070394

Integrated-Hybrid Framework for Connected and Autonomous Vehicles Microscopic Traffic Flow Modelling

Ammar Jafaripournimchahi, Yingfeng Cai, Hai Wang, Lu Sun et al. • Journal of Advanced Transportation (2022)

In this study, a novel traffic flow modeling framework is proposed considering the impact of driving system and vehicle mechanical behavior as two different units on the traffic flow. To precisely model the behavior of Connected and Autonom...

DOAJ Open Access (DOAJ) DOI: 10.1155/2022/2253697