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Academic Articles & Research Papers
Showing 20 of 877 academic articles
Zabin K. Bagewadi, Gouri H. Illanad, T. M. Yunus Khan, Shaik Mohamed Shamsudeen et al. • Bioresources and Bioprocessing
(2025)
Abstract The current investigation reports anti-cancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) and L-Glutaminase capped nanoparticles. The highest L-Glutaminase production of 9.57 U/mL w...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s40643-025-00857-w
Sara Badre-Esfahani, Lone Kjeld Petersen, Camilla Rahr Tatari, Jan Blaakær et al. • PLoS ONE
(2021)
BackgroundCervical cancer screening (CCS) and human papillomavirus vaccination (HPVV) are effective measures against cervical cancer (CC). Attendance in HPVV and CCS provides the greatest protection, while combined non-attendance in HPVV an...
DOAJ
Open Access (DOAJ)
DOI: 10.1371/journal.pone.0250816
Calum McHale, Susanne Cruickshank, Tamara Brown, Claire Torrens et al. • Pilot and Feasibility Studies
(2024)
Abstract Objectives To determine the feasibility and acceptability of implementing the Mini-AFTERc intervention. Design Non-randomised cluster-controlled pilot trial. Setting Four NHS out-patient breast cancer centres in Scotland. Participa...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s40814-023-01431-x
S. Vasanthakumar, M. Manikandan, Muthu Arumugam • Biochemistry and Biophysics Reports
(2024)
Selenium, an essential micronutrient with potent anticancer and antioxidant properties, the inorganic form of selenium is highly toxic, while organic and elemental nanoforms are more bioavailable and less toxic and have gained attention owi...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.bbrep.2024.101760
Yuxiong Lu, Junichi Maruyama, Keiko Kuwata, Hiroyuki Fukuda et al. • Biochemistry and Biophysics Reports
(2018)
Doublecortin-like kinase 1 (DCLK1) is a serine/threonine-kinase with two doublecortin (DCX) domains. DCLK1 is associated with microtubules via DCX domains and regulates microtubule polymerization. DCLK1 is known to be expressed in cancer st...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.bbrep.2018.10.014
Dipsikha Biswas, Logan Slade, Luke Duffley, Neil Mueller et al. • Cell Death Discovery
(2021)
Proposed mechanism. A Doxorubicin (DOX) targets the BCAA catabolic pathway in TNBCs, by downregulating BCKDK and augmenting clearance of intracellular BCKAs. B Genetic or pharmacological (high BT2 concentration) inhibition of BCKDK results ...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s41420-021-00602-0
Adam H. Tencer, Jiuyang Liu, Jing Zhu, Nathaniel T. Burkholder et al. • Scientific Reports
(2022)
Abstract The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein. Here, we show that the ZZ domain of HERC2 (HERC2ZZ) recognizes a mimetic of the Nt-R cargo ...
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Open Access (DOAJ)
DOI: 10.1038/s41598-022-10119-w
Maral Rahimzadeh, Majid Sadeghizadeh, Farhood Najafi, Seyed Shahriar Arab et al. • Materials Research Express
(2020)
During the last few decades, extensive studies have been conducted to elucidate the anti-cancer effects of curcumin. Despite promising results indicating curcumin could impede cancer cells ability thrive and proliferation, clinical applicat...
DOAJ
Open Access (DOAJ)
DOI: 10.1088/2053-1591/ab770f
Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z. Ring et al. • Cancer Biology & Medicine
(2017)
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Th...
DOAJ
Open Access (DOAJ)
DOI: 10.20892/j.issn.2095-3941.2016.0086
Saul Vislei Simões da Silva, Orlando Maia Barboza, Jéssica Teles Souza, Érica Novaes Soares et al. • Molecules
(2021)
Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological use. The aim of this study was to perform structural mod...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/molecules26226923
Li Rong, Haiyu Li, Zhaodong Li, Jing Ouyang et al. • Frontiers in Medicine
(2020)
Background and Objective: Chemotherapy and radiotherapy are effective treatment options for cervical cancer (CC), but their efficacy is limited by short survival rate of about 5 years particularly for advance stage CC. Bioinformatics analys...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fmed.2020.608441
Irandi Putra Pratomo, Dimas R. Noor, Kusmardi Kusmardi, Andriansjah Rukmana et al. • International Journal of Inflammation
(2021)
Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a ...
DOAJ
Open Access (DOAJ)
DOI: 10.1155/2021/1653392
Shih-Ho Wang, Chin-Hu Wu, Chin-Chuan Tsai, Tai-Yu Chen et al. • Current Issues in Molecular Biology
(2022)
Taraxacum officinale (dandelion) is often used in traditional Chinese medicine for the treatment of cancer; however, the downstream regulatory genes and signaling pathways mediating its effects on breast cancer remain unclear. The present s...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/cimb44050142
Jing Yang, Pengfei Li, Pengfei Li, Pengfei Li et al. • Frontiers in Immunology
(2022)
ObjectiveExtranodal natural killer/T cell lymphoma (NKTCL) is an aggressive EBV-related lymphoma, originating from NK cells or T cells. Previous study demonstrated that CD56 negative NKTCL should be recognized as a distinct subtype. In this...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fimmu.2022.829366
Wentong Chen, Mengxiao Ge, Shuangyi Sun, Hanxiao Zhang et al. • Scientific Reports
(2025)
Abstract As critical precursors to colorectal cancer (CRC), high-risk colorectal adenomas (HR-CRAs) lack effective chemopreventive strategies beyond endoscopic resection. We previously established a standardized protocol for culturing patie...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s41598-025-32406-y
Senyefia Bosson-Amedenu, Emmanuel Ayitey, Francis Ayiah-Mensah, Luyton Asare • BMC Cancer
(2025)
Abstract Background Frailty models are extensively utilized in survival analysis to address unobserved heterogeneity among individuals. However, selecting the most robust model for survival prediction, especially in the context of high-dime...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s12885-025-14040-z
Sipeng Shen, Ruyang Zhang, Yue Jiang, Yi Li et al. • Molecular Cancer
(2021)
Abstract N6-Methyladenosine (m6A) is an RNA modification that interacts with numerous coding and non-coding RNAs and plays important roles in the development of cancers. Nonetheless, the clinical impacts of m6A interactive genes on these ca...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s12943-021-01362-2
Yan Dora Zhang, Amber N. Hurson, Haoyu Zhang, Parichoy Pal Choudhury et al. • Nature Communications
(2020)
In cancer many gene variants may contribute to disease etiology, but the impact of a given gene variant may have varied effect size. Here, the authors analyse summary statistics of genome-wide association studies from fourteen cancers, and ...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s41467-020-16483-3
Ji Yeon Seo, Eun Hyo Jin, Goh Eun Chung, Young Sun Kim et al. • Scientific Reports
(2023)
Abstract Obesity is a risk factor for colorectal cancer. However, the effect of body weight change on colorectal cancer is uncertain. This study aimed to investigate the relationship between difference in body mass index and the risk of col...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s41598-023-36111-6
Olga Vishnyakova, Joosung Min, Stephen Leach, Xiaowei Song et al. • Communications Medicine
(2026)
Abstract Background Chronological age does not capture individual health or resilience. Advances in metabolomics have enabled development of molecular aging biomarkers that capture deviations between biological and chronological age, highli...
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Open Access (DOAJ)
DOI: 10.1038/s43856-026-01375-2