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A Focus on Simulation in Medical Informatics

James G. Anderson • Journal of the American Medical Informatics Association (2002)

This special issue of JAMIA addresses simulation, a methodology that holds great promise for the advancement of information technology in health care. Simulation has been termed a third domain, complementing both natural language and mathem...

OPENALEX Open Access DOI: https://doi.org/10.1197/jamia.m1167 PMC: 346642

Effects of individualized rTMS on functional connectivity related to the default mode network and frontal-parietal network in major depressive disorder: exploratory analysis of a randomized controlled trial

Jing Jin, Yun Wang, Sixiang Liang, Qingchen Fan et al. • NeuroImage: Clinical (2025)

Objective: Repetitive transcranial magnetic stimulation (rTMS) has been shown to alleviate depressive and anxiety symptoms in patients with major depressive disorder (MDD), typically by targeting the dorsolateral (DLPFC) or dorsomedial pref...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2025.103902

Evaluating an LLM-assisted workflow for clinical documentation: A pilot randomized controlled trial on time and quality.

Tomohiro Takayama, Keina Sado, Kenji Suda, Hiroshi Tamura et al. • PLOS Digital Health (2026)

Large language models (LLMs) have been investigated for clinical documentation, with concerns about hallucinations and factual errors. Clinician review and revision of LLM-generated drafts are considered essential; however, the impact of su...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pdig.0001799

The Effectiveness of Digital Therapeutics Intervention in Oral Anticoagulation Management: A Systematic Review and Meta-analysis

Jiayue Guo, MPH, Lili You, PhD, Lu Liu, MPH, Xitong Jiao, MPH et al. • Mayo Clinic Proceedings: Digital Health (2026)

Objective: To summarize the key intervention characteristics and evaluate the effectiveness and safety of digital therapeutics (DTx) in patients receiving oral anticoagulation, with effectiveness evaluated using time in therapeutic range (T...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.mcpdig.2026.100336

Combining Digital Cognitive Behavioral Therapy With Mindfulness Training for Binge Eating Disorder: Protocol for a Feasibility Trial

Margaret Sala, Corey Roos, Dante Ascarrunz, Casey M Stern et al. • JMIR Research Protocols (2026)

BackgroundCognitive behavioral therapy (CBT) is the most effective treatment for binge eating disorder (BED) but is limited by modest efficacy and low reach of in-person delivery. Combining mindfulness training with CBT could enhance effica...

DOAJ Open Access (DOAJ) DOI: 10.2196/91761

Percutaneous CT-Guided Bone Lesion Biopsy for Confirmation of Bone Metastases in Patients with Breast Cancer

Lucija Kovacevic, Mislav Cavka, Zlatko Marusic, Elvira Kresic et al. • Diagnostics (2022)

We aimed to determine diagnostic accuracy of CT-guided bone lesion biopsy for the confirmation of bone metastases in patients with breast cancer and assessment of hormone receptor status in metastatic tissue. A total of 56 female patients w...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics12092094

Grey matter volume associations with personality functioning in a clinical cohort of female youths

Madelyn Thomson, Marialuisa Cavelti, Ines Mürner-Lavanchy, Silvano Sele et al. • NeuroImage: Clinical (2026)

Borderline Personality Disorder (BPD) is a severe mental illness, although its neurobiological underpinnings remain largely unknown. Structural Magnetic Resonance Imaging (sMRI) in adolescents can offer insights into potential biomarkers to...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2026.103988

Effectiveness of Social Cognitive Theory–Based Interventions for Glycemic Control in Adults With Type 2 Diabetes Mellitus: Protocol for a Systematic Review and Meta-Analysis

Smith, Yvonne, Garcia-Torres, Rosalia, Coughlin, Steven S, Ling, Jiying et al. • JMIR Research Protocols (2020)

BackgroundFor those living with type 2 diabetes mellitus (T2DM), failing to engage in self-management behaviors leads to poor glycemic control. Social cognitive theory (SCT) has been shown to improve health behaviors by altering cognitive p...

DOAJ Open Access (DOAJ) DOI: 10.2196/17148

I do not want to suppress the natural process of inflammation: new insights on factors associated with non-adherence in rheumatoid arthritis

Valentin Ritschl, Angelika Lackner, Carina Boström, Erika Mosor et al. • Arthritis Research & Therapy (2018)

Abstract Background It is estimated that 50–70% of patients with rheumatoid arthritis (RA) are non-adherent to their recommended treatment. Non-adherent patients have a higher risk of not reaching an optimal clinical outcome. We explored fa...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13075-018-1732-7

Single-Case Experimental Designs to Evaluate Novel Technology-Based Health Interventions

Dallery, Jesse, Cassidy, Rachel N, Raiff, Bethany R • Journal of Medical Internet Research (2013)

Technology-based interventions to promote health are expanding rapidly. Assessing the preliminary efficacy of these interventions can be achieved by employing single-case experiments (sometimes referred to as n-of-1 studies). Although singl...

DOAJ Open Access (DOAJ) DOI: 10.2196/jmir.2227

Digital Exclusion and Cognitive Function in Elderly Populations in Developing Countries: Insights Derived From 2 Longitudinal Cohort Studies

Sainan Duan, Dongxu Chen, Jinping Wang, Mohammed Sharooq Paramboor et al. • Journal of Medical Internet Research (2024)

BackgroundCognition disorders not only lead to adverse health consequences but also contribute to a range of socioeconomic challenges and diminished capacity for performing routine daily activities. In the digital era, understanding the imp...

DOAJ Open Access (DOAJ) DOI: 10.2196/56636

A Collaborative Approach to Improving Breast Cancer Screening and Follow-Up Through Multicomponent Interventions and Process Improvements: The Links to Care Community Grants Project study protocol and baseline findings

Emily A. Prentice, Abby Moler, Amanda Sweeney, Karla Wysocki et al. • Journal of Primary Care & Community Health (2025)

Background: The Links to Care Community Grants Project was developed to improve breast cancer outcomes by increasing access to appropriate follow-up care, improving processes for care transitions, and enhancing care coordination between com...

DOAJ Open Access (DOAJ) DOI: 10.1177/21501319251357987

Understanding Public Perceptions of Lung Cancer in China: Infodemiology Study of Baidu Index and Weibo Posts

Zongyuan Li, Jian Zhang, Yiming Fan, Nan Chen et al. • Journal of Medical Internet Research (2026)

Abstract BackgroundIn China, lung cancer remains a major public health concern and accounts for a substantial proportion of cancer-related deaths nationwide. However, limited research has examined public perceptions of lung canc...

DOAJ Open Access (DOAJ) DOI: 10.2196/85058

The Use and Interpretation of Quasi-Experimental Studies in Medical Informatics

Anthony D. Harris, Jessina C. McGregor, Eli N. Perencevich, Jon P. Furuno et al. • Journal of the American Medical Informatics Association (2005)

Quasi-experimental study designs, often described as nonrandomized, pre-post intervention studies, are common in the medical informatics literature. Yet little has been written about the benefits and limitations of the quasi-experimental ap...

OPENALEX Open Access DOI: https://doi.org/10.1197/jamia.m1749 PMC: 1380192

Patient-reported outcomes and measures for vaginal relaxation syndrome management: a systematic review

Hongqin Chen, Jian Meng, Qiao Li, Xin Luo et al. • Health and Quality of Life Outcomes (2025)

Abstract Background The heterogeneity of patient-reported outcomes (PROs) and patient-reported outcome measures (PROMs) in published clinical studies on vaginal relaxation syndrome (VRS) hinders cross-study comparisons and integration of ev...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12955-025-02432-5

A Brief Intervention to Increase Uptake and Adherence of an Internet-Based Program for Depression and Anxiety (Enhancing Engagement With Psychosocial Interventions): Randomized Controlled Trial

Philip J Batterham, Alison L Calear, Matthew Sunderland, Frances Kay-Lambkin et al. • Journal of Medical Internet Research (2021)

BackgroundPsychosocial, self-guided, internet-based programs are effective in treating depression and anxiety. However, the community uptake of these programs is poor. Recent approaches to increasing engagement (defined as both uptake and a...

DOAJ Open Access (DOAJ) DOI: 10.2196/23029

Electronic symptom monitoring of patient-reported outcomes among patients with hepatocellular carcinoma during immunotherapy (PRIME-HCC): protocol for a randomised controlled trial

Yanshang Wang, Xiaoping Wei • BMJ Open (2026)

Introduction Electronic patient-reported outcome (ePROs)-based symptom monitoring benefits health-related quality of life (HRQoL) in various cancers. However, despite the high disease and economic burden of hepatocellular carcinoma (HCC) an...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2026-116199

Concurrent acute cystitis, pancolitis, and tubo-ovarian abscess following laparoscopic ovarian cystectomy: a case report

Yazan AlHabil, Anas N. Owda, Basil J. Zaid, Seema Hameedi et al. • BMC Women's Health (2024)

Abstract Background Inadequate surgical interventions can lead to serious complications such as tubo-ovarian abscesses in the upper female genital system, often resulting from untreated pelvic inflammatory disease. Pelvic inflammatory disea...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12905-024-03341-3

Determinants of Health-Related Quality of Life in Schizophrenia: Beyond the Medical Model

Madeline W. Z. Lim, Jimmy Lee, Jimmy Lee, Jimmy Lee • Frontiers in Psychiatry (2018)

Background: Improving Quality of Life (QoL) in Schizophrenia is an important treatment objective in the shift toward person-centered and recovery-oriented care. Health-Related Quality of Life (HRQoL) is a focused aspect of QoL that is direc...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpsyt.2018.00712