Academic Articles & Research Papers

An Investigation of Potential Health Risks from Zoonotic Bacterial Pathogens Associated with Farm Rats

Background: The 21st century has seen a wide range of diseases resulting from zoonotic infections, of which bacterial infections have led to outbreaks of food-borne diseases. Aim: The study looks at bacterial pathogen carriage by farm rats ...

Political Science and Conservation Biology: a Dialog of the Deaf

"The reasons political scientists neglect conservation biology and biodiversity may lie even deeper than incentives related to publication and hiring. They may have more to do with what political scientists view as the most important issues...

The relationship between political philosophy and political science

Many ‘philosophy of … .’ subjects are closely intertwined with their subject matter, using the results in, say biology, or physics, or the content of history or art, as part-and-parcel of their subject matter. Political philosophy does not ...

Immunoinformatics and Reverse Vaccinology Approach for the Identification of Potential Vaccine Candidates against <i>Vandammella animalimors</i>

Vandammella animalimorsus is a Gram-negative and non-motile bacterium typically transmitted to humans through direct contact with the saliva of infected animals, primarily through biting, scratches, or licks on fractured skin. The absence o...

Emerging natural hemp seed proteins and their functions for nutraceutical applications

With changing dietary habits and increasing awareness of the nutraceutical role of dietary foods, the demand for natural plant proteins and interest in non-traditional protein sources in the food industry are increasing. Industrial hemp, be...

Formulation, characterization, and valorization of the antioxidant, antibiofilm, and anti-adhesion potentials of a clove essential oil nanoemulsion

Food safety and control are fundamental public health issues that maintain consumer confidence and protection. This design (management) requires monitoring production, processing, and conservation processes while limiting microbiological, c...

Process-Programmed Extraction–Structure–Activity Relationships (ESAR) in edible and medicinal mushroom polysaccharides: a mechanistic and application-oriented framework

Background: Edible and medicinal mushroom polysaccharides (EMMPs) display wide-ranging bioactivities, yet progress has been limited by siloed workflows. Extraction, structural analysis, and biological evaluation are often conducted independ...

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice

Summary: Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-protein, high-carbohydrate (LPHC) diets also extend lifespan, but it is not known whether they are beneficial for brain health. We compar...

Rare genetic diseases associated with G-quadruplex-induced replication stress

Abstract DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substant...

Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration

Introduction Alzheimer’s disease and other dementias affect &gt;50 million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort and biobank studies have played a critical role in advancing the un...

Stage-Dependent Within-Individual Comparison Reveals SIV-Specific Activation/Exhaustion Shift in Rhesus Macaques

It is challenging to trace the complicated individual-based variations of HIV-specific immunocompetence shift during the successful antiretroviral therapy (ART) era. Using eight rhesus monkeys simulating a longitudinal stage-dependent cohor...

A hybrid nanomodulator enables metabolic microenvironment remodeling for potent immunotherapy against lung adenocarcinoma

STING agonist-based immunotherapy holds considerable promise for cancer treatment, yet its efficacy against immunologically “cold” tumors such as lung adenocarcinoma (LUAD) remains markedly limited. A major obstacle lies in the highly glyco...

Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

Abstract Background Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer ...

Rhizospheric Microbes and Nanoparticles Synergize to Enhance Plant Immune Responses

ABSTRACT Sustainable crop production increasingly requires innovative strategies that can enhance plant resilience while reducing dependence on synthetic agrochemicals. Recent advances in nanotechnology and rhizosphere microbiome research h...

Evaluation of resistance modulation in MDR Pseudomonas aeruginosa and Klebsiella pneumoniae using peppermint oil nanoemulsion: integrating antibacterial assays and molecular modeling

IntroductionMultidrug-resistant urinary tract pathogens, primarily Klebsiella pneumoniae and Pseudomonas aeruginosa, represent a significant and growing public health challenge. The overuse of antibiotics has accelerated the development of ...

Casearia tomentosa fruit extracts exposed larvicidal activity and morphological alterations in Culex quinquefasciatus and Aedes albopictus under in vitro and semi field conditions

Abstract Mosquitoes are notorious insects that transmit a wide range of infectious diseases, including zika, malaria, chikungunya, filariasis, and dengue. The overuse and incorrect application of synthetic pesticides to control mosquitoes h...

Multifunctional properties of Phlomis aurea extracts: In-vitro antioxidant, antimicrobial, anticancer, potent repellency against two mosquito vectors and molecular docking studies

Abstract To develop economically viable and environmentally benign methodologies for organic reactions and reveal the practical utility of transitional natural compounds and their derivatives. In addition, a new research method to conduct d...

From Tarquinia's Necropolis to biorestoration: The role of the characterization in a multidisciplinary research context

Nanotechnology: an introduction

This book provides an overview of the rapidly growing and developing field of nanotechnology, focusing on key essentials, and structured around a robust anatomy of the subject. The newcomer to nanotechnology, who may well have a strong back...

Nanotechnology: convergence with modern biology and medicine