Academic Articles & Research Papers

Rapid identification of bloodstream infection pathogens and drug resistance using Raman spectroscopy enhanced by convolutional neural networks

Bloodstream infections (BSIs) are a critical medical concern, characterized by elevated morbidity, mortality, extended hospital stays, substantial healthcare costs, and diagnostic challenges. The clinical outcomes for patients with BSI can ...

The Microbiome Composition of a Man's Penis Predicts Incident Bacterial Vaginosis in His Female Sex Partner With High Accuracy

Background: We determined the predictive accuracy of penile bacteria for incident BV in female sex partners. In this prospective cohort, we enrolled Kenyan men aged 18–35 and their female sex partners aged 16 and older. We assessed BV at ba...

Efficient covid19 disease diagnosis based on cough signal processing and supervised machine learning

The spread of the coronavirus has claimed the lives of millions around the world, which led to the emergence of an economic and health crisis at the global level, which prompted many researchers to submit proposals for early diagnosis of th...

Identification of immune-associated biomarkers of diabetes nephropathy tubulointerstitial injury based on machine learning: a bioinformatics multi-chip integrated analysis

Abstract Background Diabetic nephropathy (DN) is a major microvascular complication of diabetes and has become the leading cause of end-stage renal disease worldwide. A considerable number of DN patients have experienced irreversible end-st...

Knowledge-transfer learning for prediction of matrix metalloprotease substrate-cleavage sites

Abstract Matrix Metalloproteases (MMPs) are an important family of proteases that play crucial roles in key cellular and disease processes. Therefore, MMPs constitute important targets for drug design, development and delivery. Advanced pro...

Apoplast multi-omics profiling during fungal infection uncovers new players of basal and early induced immunity in Arabidopsis thaliana.

Epidemiology and Ecology of Toscana Virus Infection and Its Global Risk Distribution

Toscana virus (TOSV), a member of the Phlebovirus genus transmitted by sandflies, is acknowledged for its capacity to cause neurological infections and is widely distributed across Mediterranean countries. The potential geographic distribut...

Explainable machine learning for predicting clinical outcomes in HIV/TB co-infection: a comparative retrospective study

Abstract Background HIV/TB co-infection presents substantial public-health challenges, showing greater treatment-failure and mortality rates than tuberculosis alone. Recent advances in machine learning (ML) provide a robust means of identif...

Diagnostic utility of plasma heparin-binding protein and procalcitonin among patients with bacterial infections: a single-center retrospective study.

Enhancing host-pathogen phenotyping dynamics: early detection of tomato bacterial diseases using hyperspectral point measurement and predictive modeling

Early diagnosis of plant diseases is needed to promote sustainable plant protection strategies. Applied predictive modeling over hyperspectral spectroscopy (HS) data can be an effective, fast, cost-effective approach for improving plant dis...

Taxonomy-based data representation for data mining: an example of the magnitude of risk associated with H. pylori infection

Abstract Background The amount of available and potentially significant data describing study subjects is ever growing with the introduction and integration of different registries and data banks. The single specific attribute of these data...

Machine learning-derived prediction of in-hospital mortality in patients with severe acute respiratory infection: analysis of claims data from the German-wide Helios hospital network

Abstract Background Severe acute respiratory infections (SARI) are the most common infectious causes of death. Previous work regarding mortality prediction models for SARI using machine learning (ML) algorithms that can be useful for both i...

Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning

Despite the advances in surface-display systems for directed evolution, variants with high affinity are not always enriched due to undesirable biases that increase target-unrelated variants during biopanning. Here, our goal was to design a ...

Artificial intelligence for natural product drug discovery

Pandemic preparedness: Potential of routine general practice data for infectious disease early signal detection.

A web-based artificial intelligence system for label-free virus classification and detection of cytopathic effects

Abstract Identifying viral replication within cells demands labor-intensive isolation methods, requiring specialized personnel and additional confirmatory tests. To facilitate this process, we developed an AI-powered automated system called...

Machine learning insights into the burden and risk factors of lower respiratory infections in East Asia (1990-2033).

Smart IoT device for in field Black Sigatoka Disease recognition and mapping

Recently banana plantations have been affected by the Black Sigatoka Disease (BSD), producing streaks, lesions and yellow and brown spots on the leaves until the appearance of entire dead parts. The disease causes reductions in yield making...

Mitophagy in pathogenesis and therapeutic implications for infection.

Clonal haematopoiesis subtypes confer dose-dependent risk of serious bacterial infection.