Academic Articles & Research Papers

Global cancer statistics

Statistics are given for global patterns of cancer incidence and mortality for males and females in 23 regions of the world....

Therapeutic Efficacy of Orally Delivered Doxorubicin Nanoparticles in Rat Tongue Cancer Induced by 4-Nitroquinoline 1-Oxide

Purpose: Oral cancer is one of the most significant cancers in the world, and squamous cell carcinoma makes up about 94% of oral malignancies. The aim of the present study was to compare the efficacy of doxorubicin plus methotrexate - loa...

Impact of pneumonia and lung cancer on mortality of women with hypertension

Abstract Essential hypertension is one of the most severe women’s health problems. Modern life brings more chances of pulmonary diseases to human. The purpose of the study is to investigate weather pneumonia and lung cancer are associated w...

Political Science and Beyond: Presidential Address to the American Political Science Association

This is the Presidential Address delivered at the American Political Science Association Annual Meeting, Chicago, IL, August 30 to September 2, 2007. The theme is that the discipline of political science has benefited from imports from many...

Evaluation of Natural Extracts as Promising Components of Bioactive Coatings for Orthopedic Implants

The development of drug-eluting bioactive coatings for orthopedic implants has gained increased interest in recent years with an intent to reduce postoperative complications and improve tissue regeneration at the implant interface. Due to t...

Health researchers' experience collaborating with patient partners: a qualitative study

Abstract Background Patient-oriented research (POR) and patient engagement (PE) have been increasingly adopted over recent decades, as they generate many positive academic and patient outcomes within various health research fields. While th...

A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil

Immunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as “Inflammaging.” Inflammaging can be associated with many dis...

Rare genetic diseases associated with G-quadruplex-induced replication stress

Abstract DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substant...

Higher calorie intake with adequate exercise is associated with reduced mortality compared with low-calorie diet with equivalent exercise: An observational study from NHANES based on the 2020–2025 Dietary Guidelines for Americans

Object: To explore the effects of different combinations of calorie intake and exercise on all-cause, cardiovascular and cancer mortality. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Weigh...

A hybrid nanomodulator enables metabolic microenvironment remodeling for potent immunotherapy against lung adenocarcinoma

STING agonist-based immunotherapy holds considerable promise for cancer treatment, yet its efficacy against immunologically “cold” tumors such as lung adenocarcinoma (LUAD) remains markedly limited. A major obstacle lies in the highly glyco...

Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

Abstract Background Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer ...

Author Correction: Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

In recent years, the role of nanotechnology in drug delivery has become increasingly important, and this field of research holds many potential benefits for cancer treatment, particularly, in achieving cancer cell targeting and reducing the...

Advances of medical nanorobots for future cancer treatments

Abstract Early detection and diagnosis of many cancers is very challenging. Late stage detection of a cancer always leads to high mortality rates. It is imperative to develop novel and more sensitive and effective diagnosis and therapeutic ...

In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens

Introduction: Triple-negative breast cancer (TNBC) is an important subtype of breast cancer, which occurs in the absence of estrogen, progesterone and HER-2 receptors. According to the recent studies, TNBC may be a cancer testis antigen (CT...

Research Progress of Conjugated Nanomedicine for Cancer Treatment

The conventional cancer therapeutic modalities include surgery, chemotherapy and radiotherapy. Although immunotherapy and targeted therapy are also widely used in cancer treatment, chemotherapy remains the cornerstone of tumor treatment. Wi...

Multifunctional properties of Phlomis aurea extracts: In-vitro antioxidant, antimicrobial, anticancer, potent repellency against two mosquito vectors and molecular docking studies

Abstract To develop economically viable and environmentally benign methodologies for organic reactions and reveal the practical utility of transitional natural compounds and their derivatives. In addition, a new research method to conduct d...

ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine

Despite numerous studies on cancer treatment, cancer remains a challenging disease to cure, even after decades of research. In recent years, the cancer vaccine has emerged as a promising approach for cancer treatment, offering few unexpecte...

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Abstract Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergenc...

MiR-200c synergizes with trastuzumab-loaded gold nanoparticles to overcome resistance in ovarian cancer cells

Abstract Background Trastuzumab (TZ) resistance remains a significant challenge in the treatment of human epidermal growth factor receptor 2 (HER2)-positive epithelial ovarian cancer (EOC), necessitating novel therapeutic strategies to impr...