Academic Articles & Research Papers

Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition

The Taiwan Initiative for Geriatric Epidemiological Research (TIGER) was founded in 2011 to elucidate the interrelationships among various predictors of global and domain-specific cognitive impairment, with the aim of identifying older adul...

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice

Summary: Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-protein, high-carbohydrate (LPHC) diets also extend lifespan, but it is not known whether they are beneficial for brain health. We compar...

A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil

Immunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as “Inflammaging.” Inflammaging can be associated with many dis...

Long Noncoding RNAs in Neurodegenerative Diseases: Pathogenesis and Potential Implications as Clinical Biomarkers

Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are progressive and ultimately fatal. NDD onset is influenced by several fa...

Rare genetic diseases associated with G-quadruplex-induced replication stress

Abstract DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substant...

Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration

Introduction Alzheimer’s disease and other dementias affect >50 million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort and biobank studies have played a critical role in advancing the un...

Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults

Background: Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether ...

Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer’s Disease

The hallmarks of Alzheimer’s disease (AD) pathology are senile plaques containing amyloid-beta (Aβ) and neurofibrillary tangles containing hyperphosphorylated tau. Additional pathologies often co-exist, whereas multiple pathogenic mechanism...

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

The antioxidant vitamin E (α-tocopherol, α-TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with vitamin E metabolism marked by urinary α-tocopheronolactone hydroquinone (α-TLH...

One-step fabrication of superhydrophobic fabrics with stable mechanical performance in harsh conditions

Abstract Developing robust water-repellent textiles is critical for outdoor, protective, and industrial applications. However, achieving long-lasting water repellency under mechanical stress remains a significant challenge. Conventional app...

The electrochemical effects of pitch stabilization for supercapacitor-grade activated carbon precursors

Petroleum pitch (PP) is a by-product generated during the petroleum refining process, characterized by its high carbon content, tunable structure, and cost-effectiveness. These attributes have spurred extensive research into its potential a...

Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

Abstract Background Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer ...

Microstructure and corrosion behavior of SLM–Ti6Al4V with different fabrication angles in F−-containing solutions

Selective laser fusion (SLM) is an emerging 3D printing technology that can greatly shorten the processing cycle and reduce the production cost of medical implants, thus offering broad prospects for application in the biomedical field. In a...

Essentials of Materials Science and Engineering

This text provides students with a solid understanding of the relationship between the structure, processing, and properties of materials. Authors Donald Askeland and Pradeep Fulay teach the fundamental concepts of atomic structure and beha...

Practical Handbook of Materials Science

CRC Practical Handbooks are a series of single-volume bench manuals that feature a synthesis of frequently used, basic reference information. These highly abridged versions of existing CRC multi-volume Handbooks contain largely tabular and ...

An In Vitro Study of Local Oxygen Therapy as Adjunctive Antimicrobial Therapeutic Option for Patients with Periodontitis

Periodontitis is a common global disease caused by bacterial dysbiosis leading to tissue destruction, and it is strongly associated with anaerobic bacterial colonization. Therapeutic strategies such as oxygen therapy have been developed to ...

Effect of Heat Input on Microstructure and Hardness Distribution of Laser Welded Si-Al TRIP-Type Steel

This study is concerned with issues related to laser welding of Si-Al type TRIP steels with Nb and Ti microadditions. The tests of laser welding of thermomechanically rolled sheet sections were carried out using keyhole welding and a solid-...

Author Correction: Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy

Decellularized Placental Sponge: A Platform for Coculture of Mesenchymal Stem Cells/Macrophages to Assess an M2 Phenotype and Osteogenic Differentiation In Vitro and In Vivo

In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens

Introduction: Triple-negative breast cancer (TNBC) is an important subtype of breast cancer, which occurs in the absence of estrogen, progesterone and HER-2 receptors. According to the recent studies, TNBC may be a cancer testis antigen (CT...