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Low-grade chronic inflammation and transcriptomics: how molecular pharmacognosy can help find new natural treatment alternatives—a narrative review

Massimo Fioranelli, Maria Grazia Roccia, Bianca Przybylek, Francesca Romana Sconci et al. • Beni-Suef University Journal of Basic and Applied Sciences (2024)

Abstract Background The inflammatory response is fundamental to the maintenance of an organism’s physiological homeostasis. Inflammation is controlled by a series of biological events driven by specific inflammatory molecules. When inflamma...

DOAJ Open Access (DOAJ) DOI: 10.1186/s43088-024-00506-9

Heat transfer by three types of hot pack and its implication on the flexibility of the lower back: a randomized, controlled trial

Paulina Fuentes-León, Natalia Jara-Poblete, Pía Bastías-Sánchez, Kaio Fernando Vitzel et al. • Fisioterapia e Pesquisa (2016)

ABSTRACT The use of hot pack is a common superficial thermotherapy strategy and one of its benefits is the increase of muscle flexibility. However, there is a lack of information about the effects of the heat pack alone, without being used ...

DOAJ Open Access (DOAJ) DOI: 10.1590/1809-2950/15088923022016

Plexiform Neurofibroma Treated with Pharmacopuncture

Chungsan Lim, Kirok Kwon, Kwangho Lee • Journal of Pharmacopuncture (2014)

Objectives: The purpose of this study is to report a case of a plexiform neurofibroma (PNF) in the pelvic region treated with sweet bee venom (SBV) and mountain ginseng pharmacopuncture (MGP). Methods: A 16-year-old girl was diagnosed as h...

DOAJ Open Access (DOAJ) DOI: 10.3831/KPI.2014.17.030

The Utilization of Plant-Material-Loaded Vesicular Drug Delivery Systems in the Management of Pulmonary Diseases

Bongani Sannyboy Lukhele, Kokoette Bassey, Bwalya Angel Witika • Current Issues in Molecular Biology (2023)

Medicinal plants have been utilized to treat a variety of conditions on account of the bioactive properties that they contain. Most bioactive constituents from plants are of limited effectiveness, due to poor solubility, limited permeabilit...

DOAJ Open Access (DOAJ) DOI: 10.3390/cimb45120624

Efficacy, safety, and quality of life 4 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A in the phase 3 GENEr8-1 trial

Andrew D. Leavitt, Johnny Mahlangu, Priyanka Raheja, Emily Symington et al. • Research and Practice in Thrombosis and Haemostasis (2024)

Background: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection. Objectives: Determine valoctocogene roxaparvovec du...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rpth.2024.102615

Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm

Hee-Sung Chae, Sun Young Kim, Pisey Pel, Jungmoo Huh et al. • Molecules (2020)

Cough and phlegm frequently occur in respiratory diseases like upper respiratory tract infections, acute bronchitis, and chronic obstructive pulmonary diseases. To relieve these symptoms and diseases, various ingredients are being used desp...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules25133064

Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases

Li Tao, Xiaomeng Ren, Wenhui Zhai, Zheng Chen • Molecules (2022)

Non-canonical nuclear factor kappa B (NF-κB) signaling pathway regulates many physiological and pathological processes, including liver homeostasis and diseases. Recent studies demonstrate that non-canonical NF-κB signaling pathway plays an...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules27134275

EFFECT OF VITAMIN A ON CYCLOSPORINE NEPHROTOXICITY IN UNINEPHRECTOMIZED RATS

Hoda Mohamed, Hazar Yacoub, Heba Ameen, Dureah Sebah • Zagazig Journal of Pharmaceutical Sciences (1997)

The influence of vitamin A (1.5 mg kg-1 body weight) administration for two weeks on cyclosporine A (CsA, 25 mg kg-1 body weight) induced renal dysfunction has been investigated in uninephrectomized and sham nephrectomized rats. Single kidn...

DOAJ Open Access (DOAJ) DOI: https://doi.org/10.21608/zjps.1997.184951

Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress

Haruka Furuta, Mari Yamada, Takuya Nagashima, Shuichi Matsuda et al. • Frontiers in Pharmacology (2023)

Tendinopathy, a degenerative disease, is characterized by pain, loss of tendon strength, or rupture. Previous studies have identified multiple risk factors for tendinopathy, including aging and fluoroquinolone use; however, its therapeutic ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2023.1137952

Perspective on the Therapeutics of Anti-Snake Venom

Isabel Gómez-Betancur, Vedanjali Gogineni, Andrea Salazar-Ospina, Francisco León • Molecules (2019)

Snakebite envenomation is a life-threatening disease that was recently re-included as a neglected tropical disease (NTD), affecting millions of people in tropical and subtropical areas of the world. Improvement in the therapeutic approaches...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules24183276

Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-κB Signaling Cascades

Xinpeng Jiang, Shanshan Gu, Di Liu, Lili Zhao et al. • Frontiers in Microbiology (2018)

Aims:Lactobacillus strains have protective effects against heavy metals while relieving oxidative stress and modulating the immune response. Mechanisms that ameliorate heavy metal toxicity and the relationship between probiotics and gut bar...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2018.02425

Role of pyroptosis in spinal cord injury and its therapeutic implications

Abdullah Al Mamun, Yanqing Wu, Ilma Monalisa, Chang Jia et al. • Journal of Advanced Research (2021)

Background: Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosi...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jare.2020.08.004

Modified Riceberry rice extract suppresses melanogenesis-associated cell differentiation through tyrosinase-mediated MITF downregulation on B16 cells and in vivo zebrafish embryos

Teerapat Rodboon, Sasithorn Sirilun, Seiji Okada, Ryusho Kariya et al. • Research in Pharmaceutical Sciences (2020)

Background and purpose: Excessive melanin production caused by overactive tyrosinase (TYR) enzyme results in several dermatological problems. The TYR inhibitor, derived from metabolite changes during fermentation, has been well recognized f...

DOAJ Open Access (DOAJ) DOI: 10.4103/1735-5362.297852

Mechanism analysis of mechanical extraction of Pleioblastus amarus fibers by saturated steam pretreatment

Xiaofeng Xu, Weipeng Yu, Xingduo Fan, Zhenhong Gong et al. • Scientific Reports (2025)

Abstract Currently, bamboo fibers (BFs) are commonly processed through alkali boiling softening pretreatment, which generates wastewater that poses environmental pollution risks. This process is also complex and requires significant human a...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-88059-4

An elderly low-grade fibromyxoid sarcoma patient with early postoperative recurrences and metastases: a case report and literature review

Xiaoyue Zhang, Yongkang Qiu, Jixin Zhang, Zhao Chen et al. • Frontiers in Medicine (2024)

BackgroundLow-grade fibromyxoid sarcoma (LGFMS) is a rare type of soft tissue sarcoma that often involves the deep soft tissue of the extremities and trunk in young and middle-aged adults. It is uncommon in the elderly. Here we discuss a ca...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2024.1172746

Enhancing Rosemary (<i>Rosmarinus officinalis</i>, L.) Growth and Volatile Oil Constituents Grown under Soil Salinity Stress by Some Amino Acids

Ahmad H. Al-Fraihat, Sati Y. Al-Dalain, Ahmad A. Zatimeh, Moawiya A. Haddad • Horticulturae (2023)

The current study was carried out during the two consecutive winter seasons of 2019/2020 and 2020/2021 at the Experimental Farm of Ash-Shoubak University College, Jordan, as a pot experiment. This experiment was planned to evaluate the impa...

DOAJ Open Access (DOAJ) DOI: 10.3390/horticulturae9020252

Essential Oils from Artemisia herba alba Asso., Maticaria Recutita L., and Dittrichia Viscosa L. (Asteraceae): A Promising Source of Eco-Friendly Agents to Control Callosobruchus maculatus Fab. Warehouse Pest

Allali Aimad, Mohammed Bourhia, Hadin Hana, Rezouki Sanae et al. • Journal of Chemistry (2022)

Callosobruchus maculatus (Fab.) (C. maculatus) is one of the major pests of legume seeds in storage causing significant damage, leading to food insecurity and low income for farmers. This work was planned to develop eco-friendly agents from...

DOAJ Open Access (DOAJ) DOI: 10.1155/2022/2373460