Academic Articles & Research Papers

Mitigation of salinity stress in canola plants by sodium nitroprusside application

Salinity is a global issue threatening land productivity and food production. The present study aimed to examine the role of sodium nitroprusside (SNP) on the alleviation of NaCl stress on different parameters of canola (Brassica napus L.) ...

Analysis of taxonomic distinctness and priority conservation areas as a basis for heritage enhancement of floristic diversity: the case of the ‘hotspot’ of the islands of Numidia (North-eastern Algeria)

The identification of priority conservation areas (PCA) plays an important role in biodiversity conservation, but uncertainties create challenges for conservation planning. The objective was to test a method based on 'taxonomic distinctness...

Biosynthesis of rare 20(R)-protopanaxadiol/protopanaxatriol type ginsenosides through Escherichia coli engineered with uridine diphosphate glycosyltransferase genes

Background: Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace ...

TAXONOMIC REVISION OF THE FAMILY CASUARINACEAE R. BR., 1814 (ORDER, FAGALES) IN EGYPT

Bumblebees and pollination of endemic Onobrychis pindicola (Fabaceae) in the subalpine habitats of Pirin Mts

Onobrychis pindicola subsp. urumovii Degen & Dren. is an endemic with restricted distribution on Pirin Mts. and Slavjanka Mts. (Balkan Peninsula, SW Bulgaria). It is obligatorily dependent upon insect vectors for pollen transport, being a s...

Biodiversidade e considerações biogeográficas das Cyanobacteria de uma área de Manguezal do Estado de Pernambuco, Brasil

Manguezais caracterizam-se por apresentarem amplas variações ambientais (principalmente de salinidade, irradiância e teor de oxigênio) e possuírem substrato relativamente instável, o que exige adaptações específicas dos organismos para habi...

Functional relation of Actinidia species phytohormonal status with regeneration ability and sex of plants

Endogenous content of phytohormones has been investigated in one-year shoots of different actinidia species, which were introduced in Ukraine. Relationship between phytohormon status of plants and their ability to rooting was established. O...

Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding

Neuronal signaling has an important role in the regulation of energy expenditure and body weight, however, the underlying mechanisms are incompletely understood. Here, the authors report a AgRP-MC4R-serotonin expressing neuronal circuit tha...

The molecular crosstalk between RECQ helicases and associated proteins in human genetic disorders

RECQ helicases involve a family of DNA unwinding enzymes, namely, RECQ1, Bloom syndrome protein, Werner syndrome protein, RECQL4, and RECQ5. These proteins interact with various proteins to form complexes and carry out a range of physiologi...

Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

Regenerative therapy for degenerative spine disorders requires the identification of cells that can slow down and possibly reverse degenerative processes. Here, we identify an unanticipated wound-specific notochord sheath cell subpopulation...

Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways

Abstract Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bi...

Functional MRI of Handwriting Tasks: A Study of Healthy Young Adults Interacting with a Novel Touch-Sensitive Tablet

Handwriting is a complex human activity that engages a blend of cognitive and visual motor skills. Current understanding of the neural correlates of handwriting has largely come from lesion studies of patients with impaired handwriting. Tas...

Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival

Emerging scaffold structures made of carbon nanomaterials, such as graphene oxide (GO) have shown efficient bioconjugation with common biomolecules. Previous studies described that GO promotes the differentiation of neural stem cells and ma...

Sexual Dimorphism in Growth Rate and Gene Expression Throughout Immature Development in Wild Type Chrysomya rufifacies (Diptera: Calliphoridae) Macquart

Reliability of forensic entomology analyses to produce relevant information to a given case requires an understanding of the underlying arthropod population(s) of interest and the factors contributing to variability. Common traits for analy...

The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation

The Atr-Check1 pathway is involved in cell cycle and the DNA damage response. Here, the authors show that the Atr-Check1 pathway can inhibit axon regeneration in response to Piezo-mediated mechanosensation, affecting functional recovery....

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with satu...

Green synthesis, characterization and functional validation of bio-transformed selenium nanoparticles

Selenium, an essential micronutrient with potent anticancer and antioxidant properties, the inorganic form of selenium is highly toxic, while organic and elemental nanoforms are more bioavailable and less toxic and have gained attention owi...

Technosignatures Longevity and Lindy's Law

The probability of detecting technosignatures (i.e., evidence of technological activity beyond Earth) increases with their longevity, or the time interval over which they manifest. Therefore, the assumed distribution of longevities has some...

Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability

Doublecortin-like kinase 1 (DCLK1) is a serine/threonine-kinase with two doublecortin (DCX) domains. DCLK1 is associated with microtubules via DCX domains and regulates microtubule polymerization. DCLK1 is known to be expressed in cancer st...

Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity

Proposed mechanism. A Doxorubicin (DOX) targets the BCAA catabolic pathway in TNBCs, by downregulating BCKDK and augmenting clearance of intracellular BCKAs. B Genetic or pharmacological (high BT2 concentration) inhibition of BCKDK results ...