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Showing 16 of 36 academic articles

Camel Milk Targeting Insulin Receptor—Toward Understanding the Antidiabetic Effects of Camel Milk

Irfa Anwar, Farheen Badrealam Khan, Sajid Maqsood, Mohammed Akli Ayoub et al. • Frontiers in Nutrition (2022)

Camel milk (CM) is known for its beneficial virtues in the human diet and health. This includes its antidiabetic properties demonstrated in many in vitro and in vivo studies. Nevertheless, the scientific rationale behind the molecular and c...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnut.2021.819278

Mangifera Indica leaf extracts promote hair growth via activation of Wnt signaling pathway in human dermal papilla cells

Haesoo Jung, Da-Min Jung, Sang-Soo Lee, Eun-Mi Kim et al. • Animal Cells and Systems (2022)

The crosstalk between androgens and Wnt signaling pathways is critical in the hair growth cycle. Therefore, natural products that target these two pathways for the inhibition of hair loss are sought after. In this study, we investigated the...

DOAJ Open Access (DOAJ) DOI: 10.1080/19768354.2022.2085790

Astaxanthin biofortification enhances tobacco tolerance to lead stress through boosting antioxidant defense, reducing Pb accumulation, and modulating detoxification pathways

Zhongyang Du, Mengjing Liang, Xiaodan Wang, Yizhen Liu et al. • Journal of Advanced Research (2026)

Introduction: Heavy metal pollution including lead (Pb) has become one of the serious global issues threatening food security, human health, and the ecosystem. Exogenous application of astaxanthin (ATX), a potent natural antioxidant, has be...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jare.2025.07.038

Dichloroacetate as a metabolic modulator of heart mitochondrial proteome under conditions of reduced oxygen utilization

Natalia Andelova, Iveta Waczulikova, Lukas Kunstek, Ivan Talian et al. • Scientific Reports (2022)

Abstract Myocardial compensatory mechanisms stimulated by reduced oxygen utilization caused by streptozotocin-induced diabetes mellitus (DM) and treated with dichloroacetate (DCA) are presumably associated with the regulation of mitochondri...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-022-20696-5

Identification of brain regions predicting epileptogenesis by serial [18F]GE-180 positron emission tomography imaging of neuroinflammation in a rat model of temporal lobe epilepsy

Vera Russmann, Matthias Brendel, Erik Mille, Angela Helm-Vicidomini et al. • NeuroImage: Clinical (2017)

Excessive activation of inflammatory signaling pathways seems to be a hallmark of epileptogenesis. Positron emission tomography (PET) allows in vivo detection of brain inflammation with spatial information and opportunities for longitudinal...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2017.04.003

RETRACTED ARTICLE: Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus

Vassilis L. Souliotis, Konstantinos Vougas, Vassilis G. Gorgoulis, Petros P. Sfikakis • Arthritis Research & Therapy (2016)

Abstract Background Excessive autoantibody production characterizing systemic lupus erythematosus (SLE) occurs irrespective of the disease’s clinical status and is linked to increased lymphocyte apoptosis. Herein, we tested the hypothesis t...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13075-016-1081-3

Effect of Short-term Treated Wastewater Application on Physiological Traits and Stress-related Genes (CaCAT2, CaDREB32, CaLOX1) in Pepper

Merve Dilek KARATAŞ • ISPEC Journal of Agricultural Sciences (2025)

This study investigated the effects of treated wastewater irrigation on physiological traits and gene expression in pepper (Capsicum annuum) plants during early development. Control (tap water) and treated wastewater treatments were compare...

DOAJ Open Access (DOAJ) DOI: 10.5281/zenodo.17879057

Integrated methylome and transcriptome analysis provides insight into DNA methylation-mediated networks in sexual dimorphism of Vernicia montana

Xiang Dong, Lin Zhang, Huaguo Zhu, Jinping Peng et al. • BMC Plant Biology (2026)

Abstract Background Sexual dimorphism is fundamental to reproduction in dioecious plants and is regulated by both genetic and epigenetic mechanisms. DNA methylation is a central epigenetic mark known to influence phenotypic variation in pla...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12870-026-09376-y

CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling

Xindong Wei, Anfeng Si, Shuai Zhao, Yi Fu et al. • Cellular & Molecular Biology Letters (2025)

Abstract Background Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (H...

DOAJ Open Access (DOAJ) DOI: 10.1186/s11658-025-00690-1

Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies

M. Camila Melo-Narvaez, Fee Gölitz, Eshita Jain, Janine Gote-Schniering et al. • Respiratory Research (2025)

Abstract Background Human precision-cut lung slices (hPCLS) are a unique platform for functional, mechanistic, and drug discovery studies in the field of respiratory research. However, tissue availability, generation, and cultivation time r...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12931-025-03132-w

The critical involvement of monocytes/macrophages in the pathogenesis of primary Sjögren's syndrome: New evidence from Mendelian randomization and single-cell sequencing

Yimei Ding, Xue Luan, Jiaqi Hou • Heliyon (2024)

Background: Primary Sjögren's syndrome (pSS) stands as a chronic autoimmune disease characterized by an elusive pathogenesis. The synergy of single-cell RNA sequencing and Mendelian randomization (MR) analysis provides an opportunity to com...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2024.e39130

Advances in Retinal Stem Cell Biology

Andrea S Viczian • Journal of Ophthalmic & Vision Research (2013)

Tremendous progress has been made in recent years to generate retinal cells from pluripotent cell sources. These advances provide hope for those suffering from blindness due to lost retinal cells. Understanding the intrinsic genetic network...

DOAJ Open Access (DOAJ)

Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer

Ruifang Li, Sara A. Grimm, Deepak Mav, Haiwei Gu et al. • Cell Reports (2018)

Colorectal cancer (CRC) tends to occur at older age; however, CRC incidence rates have been rising sharply among young age groups. The increasing prevalence of obesity is recognized as a major risk, yet the mechanistic underpinnings remain ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.celrep.2017.12.071

Racially Disparate Expression of mTOR/ERK-1/2 Allied Proteins in Cancer

Sanjay Mishra, Manish Charan, Ajeet Kumar Verma, Bhuvaneswari Ramaswamy et al. • Frontiers in Cell and Developmental Biology (2021)

Recent studies revealed that ethnic differences in mechanistic target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK-1/2) signaling pathways might be associated with the development and progression of different human mal...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcell.2021.601929

How <i>Phytophthora</i> Effectors Disrupt Post-Translational Regulation in Plant Immunity: Canonical and Non-Canonical Mechanisms

Gilberto Muñoz-Pérez, Fátima Álvarez-Camarena, Julio Vega-Arreguin • Kinases and Phosphatases (2026)

Plant–pathogen interactions are shaped by dynamic regulatory processes that control immune signaling. Among these, post-translational modifications (PTMs) play central roles in modulating protein activity, stability, and interaction network...

DOAJ Open Access (DOAJ) DOI: 10.3390/kinasesphosphatases4020011

Biomaterial Engineering for Spatiotemporal Regulation of Exosome Functions: From Design Principles to Key Applications in Regenerative Medicine

Shan Long, Bo Wang, Shaodong Tian, Honglan Tang et al. • Pharmaceuticals (2026)

As natural nanoscale intercellular messengers, exosomes exhibit considerable potential in modulating inflammation, angiogenesis, immunoregulation, and tissue remodeling, making them attractive candidates for regenerative medicine. However, ...

DOAJ Open Access (DOAJ) DOI: 10.3390/ph19050672