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First Report of Ciguatoxins in Two Starfish Species: Ophidiaster ophidianus and Marthasterias glacialis

Marisa Silva, Inés Rodriguez, Aldo Barreiro, Manfred Kaufmann et al. • Toxins (2015)

Ciguatera fish poisoning (CFP) is a syndrome caused by the ingestion of fish contaminated with Ciguatoxins (CTXs). These phycotoxins are produced mainly by dinoflagellates that belong to the genus Gambierdiscus that are transformed in more...

DOAJ Open Access (DOAJ) DOI: 10.3390/toxins7093740

Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages

Hai-Ning Wee, Soek-Ying Neo, Deepika Singh, Hui-Chuing Yew et al. • BMC Complementary Medicine and Therapies (2020)

Abstract Background Dysregulation of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) form the basis of immune-mediated inflammatory diseases. Vitex trifolia L. is a medicinal plant growing in co...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12906-020-02884-w

Analysis of Cathinone Alkaloids in Khat by HPLC-Q-TOF In-source Fragmentation Multistage Mass Spectrometry

SHI Hong-fei1, XU Bo-peng1, QUAN Yang-ke2, XU Cheng-xin1, ZHOU Xiu-qi1 • Zhipu Xuebao (2024)

Khat is a kind of common drug plant. Many experiments have shown that the content of cathinone norpseudoephedrine and norephedrine in some varieties of Khat are similar. However, some studies showed that there are differences in the intensi...

DOAJ Open Access (DOAJ) DOI: 10.7538/zpxb.2023.0065

Comparative analysis of chemical toxicological studies of pregabalin in neuropathic pain management (review)

Nargiz Parkhatkyzy, Alma Shukirbekova, Zumrad Usmanalieva, Kundyzay Mirzakir et al. • Journal of Pharmacy & Pharmacognosy Research (2026)

Context: The use of pregabalin in neuropathic pain management has been increasingly associated with concerns regarding toxicity, particularly in cases of overdose, misuse, and co-exposure with central nervous system depressants. In parallel...

DOAJ Open Access (DOAJ) DOI: 10.56499/jppres_14.3.2550

Detection Techniques for Synthetic Cannabinoids in Body Fluids and Tissues: A Systematic Review

Sachil Kumar, Tulsidas R. Baggi • Journal of Forensic Science and Medicine (2026)

Synthetic cannabinoids (SCs), originally developed for research purposes in the 1960s, have emerged as a significant concern in clinical and forensic toxicology due to their widespread abuse and unpredictable toxicological effects. These co...

DOAJ Open Access (DOAJ) DOI: 10.4103/jfsm.jfsm_128_25

Impact of Pressurized Liquid Extraction and pH on Protein Yield, Changes in Molecular Size Distribution and Antioxidant Compounds Recovery from Spirulina

Jianjun Zhou, Min Wang, Celia Carrillo, Zhenzhou Zhu et al. • Foods (2021)

The research aims to extract nutrients and bioactive compounds from spirulina using a non-toxic, environmentally friendly and efficient method—Pressurized Liquid Extraction (PLE). In this work, Response Surface Methodology (RSM)–Central Com...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods10092153

Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS

Xinyi Wei, Yanding Su, Qian Cheng, Songmao Liang et al. • Frontiers in Pharmacology (2024)

Objective: A remarkably sensitive, accurate, and efficient ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach was developed as a facile and expeditious method for measuring cilofexor concentration in beag...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2024.1334402

The Effect of Yinchenhao Decoction on the Pharmacokinetic Profile of Futibatinib by HPLC-MS/MS

Chunfu Wang, Songmao Liang, Jiachen Xu, Yingfan Zhai et al. • Separations (2024)

Futibatinib is an excellent fibroblast growth factor receptor 1–4 (FGFR 1–4) inhibitor that exhibits selective anti-tumor activeness against FGFR-deregulated tumors. A new high-performance liquid chromatography-tandem mass spectrometry (HPL...

DOAJ Open Access (DOAJ) DOI: 10.3390/separations11070213

Chemical Diversity of Fuzhuan Brick Teas from Hunan and Shaanxi

ZHANG Ning, YU Shilan, YAN Haoyi, ZHANG Yunjun, HAN Xiaoyu, REN Hongyu, CHEN Yuqing, LING Tiejun, AN Maoqiang • Shipin Kexue (2024)

This study aimed to explore the diversity of metabolites and compare the metabolite profiles of Fuzhuan brick teas from Hunan and Shaanxi, to find out the difference in chemical components between fresh tea leaves and Fuzhuan brick tea and ...

DOAJ Open Access (DOAJ) DOI: 10.7506/spkx1002-6630-20231108-066

Unraveling the formation mechanism of 3-methylindole from tryptophan in the glucose-mediated Maillard reaction: a combined ReaxFF MD, DFT, and experimental study

Yuan-Yuan Yang, Chao-Kun Wei, Xin Pan, An-Ran Zheng et al. • Food Chemistry: X (2026)

3-Methylindole is a concentration-dependent aroma compound, and its formation mechanism in the tryptophan-glucose Maillard reaction is crucial for flavor regulation but remains incompletely elucidated. Using gas chromatography-olfactometry-...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.fochx.2026.104719

Advances in High Throughput Proteomics Profiling in Establishing Potential Biomarkers for Gastrointestinal Cancer

Md Zahirul Islam Khan, Shing Yau Tam, Helen Ka Wai Law • Cells (2022)

Gastrointestinal cancers (GICs) remain the most diagnosed cancers and accounted for the highest cancer-related death globally. The prognosis and treatment outcomes of many GICs are poor because most of the cases are diagnosed in advanced me...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells11060973

Effects of an infant formula containing a whey protein concentrate on feeding tolerance and markers of intestinal immune defense in Chinese infants

Ying Wang, Min Liu, Shaillay Kumar Dogra, Karine Vidal et al. • BMC Nutrition (2026)

Abstract Background Human milk (HM) bioactive components can have immune modulatory functions, impact the gut microbiome, and may result in functional benefits when added to infant formula (IF). In this single-arm, prospective, intervention...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40795-026-01395-0

Molecular Informatics, Chemometrics, and Sensory Omics for Constructing an Umami Peptide Cluster Library Across the Entire Lager Beer Brewing Process

Yashuai Wu, Ruiyang Yin, Wenjing Tian, Wanqiu Zhao et al. • Foods (2026)

Umami taste in lager beer not only determined body fullness and the backbone of aftertaste, but also affected the controllability and interpretability of flavor expression across the entire brewing process. Based on stage-wise sampling, pep...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods15040641

Purification, Characterization and Bactericidal Action of Lysozyme, Isolated from <i>Bacillus subtillis</i> BSN314: A Disintegrating Effect of Lysozyme on Gram-Positive and Gram-Negative Bacteria

Muhammad Naveed, Yadong Wang, Xian Yin, Malik Wajid Hussain Chan et al. • Molecules (2023)

In the present study, lysozyme was purified by the following multi-step methodology: salt (ammonium sulfate) precipitation, dialysis, and ultrafiltration. The lysozyme potential was measured by enzymatic activity after each purification ste...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules28031058

G-Aligner: a graph-based feature alignment method for untargeted LC–MS-based metabolomics

Ruimin Wang, Miaoshan Lu, Shaowei An, Jinyin Wang et al. • BMC Bioinformatics (2023)

Abstract Background Liquid chromatography–mass spectrometry is widely used in untargeted metabolomics for composition profiling. In multi-run analysis scenarios, features of each run are aligned into consensus features by feature alignment ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12859-023-05525-4

Medical Biotechnology

Dylan R. Pillai • Clinical Infectious Diseases (2014)

Both the diagnosis and treatment of human disease have undergone radical changes since the seminal discoveries of molecular biology, magnetic resonance imaging, mass spectrometry, and vaccine development, to name but a few. Glick and collea...

OPENALEX DOI: https://doi.org/10.1093/cid/ciu510

Ion Mobility Mass Spectrometry Reveals Rare Sialylated Glycosphingolipid Structures in Human Cerebrospinal Fluid

Mirela Sarbu, Dragana Fabris, Željka Vukelić, David E. Clemmer et al. • Molecules (2022)

Gangliosides (GGs) represent an important class of biomolecules associated with the central nervous system (CNS). In view of their special role at a CNS level, GGs are valuable diagnostic markers and prospective therapeutic agents. By ion m...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules27030743

β-D-galactopyranoside Seco-phytoporphyrin from Atropa Belladonna and Solanum Tuberosum Yellow Leaves Determined by Nuclear Magnetic Resonance

Nina Djapic • Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry (2021)

The study described the isolation of β-D-galactopyranoside seco-phytoporphyrin from Atropa belladonna and Solanum tuberosum yellow leaves. Column chromatography was applied for its isolation. The UV-Vis, mass spectrometry and NMR spectrosco...

DOAJ Open Access (DOAJ) DOI: 10.19261/cjm.2021.861