Academic Articles & Research Papers

Kurarinol A from Sophora flavescens suppresses hepatic stellate cell activation via the TLR4/MyD88/NF-κB pathway.

Systemic regulation of rhizosphere nutrient activation by polyol-chelated fertilizers: evidence and a conceptual framework.

From activation to desensitization: How ABA balances plant growth and abiotic stress response?

Trial tribulations: Lessons learned from an unsuccessful pilot trial of Behavioural Activation in young people with early or emerging psychosis at a regional mental health service.

Mutation-induced penicillin binding protein 2A inactivation through CRISPR-dCas9 gene editing in methicillin-resistant S. aureus.

Synergistic Effects of Resveratrol and Temozolomide Against Glioblastoma Cells: Underlying Mechanism and Therapeutic Implications

Yusi Liu, Xue Song, Moli Wu, Jiao Wu, Jia Liu Liaoning Laboratory of Cancer Genetics and Epigenetics and Department of Cell Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, People’s Republic of ChinaCorre...

CRISPR/Cas9 for hepatitis B virus infection treatment

Abstract Hepatitis B virus (HBV) infection remains a global health challenge. Despite the availability of effective preventive vaccines, millions of people are at risk of cirrhosis and hepatocellular carcinoma. Current drug therapies inhibi...

Abnormal X : autosome ratio, but normal X chromosome inactivation in human triploid cultures

Abstract Background X chromosome inactivation (XCI) is that aspect of mammalian dosage compensation that brings about equivalence of X-linked gene expression between females and males by inactivating one of the two X chromosomes (Xi) in nor...

Elevated Eosinophils as a Feature of Inflammation Associated With Hypertension in Virally Suppressed People Living With HIV

Background People living with HIV (PLWH) are at increased risk of cardiovascular disease, including hypertension, which persists despite effective plasma viral suppression on antiretroviral therapy. HIV infection is characterized by long‐te...

Patrimonio cultural y turismo emergente: Villa Guillermina, de pueblo obrero a nuevo destino turístico. Un estudio de caso Patrimônio cultural e turismo emergente: Villa Guillermina, de povoado de operários a novo destino turístico. Um estudo de caso Cultural Heritage and emergent tourism: Villa Guillermina from worker villages to a new tourist destination. A case study

En los últimos años, la provincia de Santa Fe ha impulsado una política destinada a la creación de nuevos destinos turísticos, con el propósito de contribuir al desarrollo de las economías locales. Villa Guillermina, situada en la Cuña Bosc...

Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats

Autism spectrum disorder (ASD) is a developmental condition whose primary features include social communication and interaction impairments with restricted or repetitive motor movements. No approved treatment for the core symptoms is availa...

Urban Fear, Criminality and the Erosion of Intangible Cultural Access in Machala: A Critical Qualitative Content Analysis of Ecuadorian National Digital Press

This article examines how the Ecuadorian national digital press has represented the relationship between criminal violence, declining mobility, tourism contraction, and the erosion of intangible cultural access in Machala, Puerto Bolívar, a...

Postbiotics in Functional Foods: Preparation-Based Characterization, Gut–Brain Axis Interactions, and Translational Perspectives

Postbiotics are defined as preparations of inanimate microorganisms and/or their components that confer a health benefit on the host. Although interest in postbiotics has increased substantially, their translational use in functional foods ...

Remodeling of Metabolic and Secretory Organelles During Oncogenic and Oncomodulatory Viral Infections

Persistent oncovirus infections account for 15–20% of the global cancer burden, driving multiple forms of human cancer. To maintain persistent infection and spread, oncoviruses drive alterations in host cell metabolism, immune signaling, an...

CAFs activated by YAP1 upregulate cancer matrix stiffness to mediate hepatocellular carcinoma progression

Abstract Background The stiffness of the matrix is closely related to the progression of hepatocellular carcinoma (HCC). Although direct targeting of stromal rigidity in HCC remains a clinical challenge, cancer-associated fibroblasts (CAFs)...

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Tumor necrosis factor alpha (TNF) is a multifunctional cytokine, which possesses various biologic functions depending on the type of the cells and the physiological context. TNF is synthesized by immune cells as well as malignant cells. Acc...

Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase

Several members of the genus Legionella cause Legionnaires’ disease, a potentially debilitating form of pneumonia. Studies frequently focus on the abundant number of virulence factors present in this genus. However, what is often overlooked...

CHANGES IN PATTERNS OF SENSORIMOTOR EEG RHYTHMS DURING MOTOR IMAGERY

Aim - the determination of common and individual characteristics in patterns of sensorimotor rhythms of EEG during motor imagery in upper and lower limbs. Materials and methods. 20 right-handed students of Samara State Medical University at...

«Being Together» in Pandemic Conditions: Social Cohesion Challenges of the Contemporary Ukrainian Society

The article is dedicated to the analysis of the Ukrainian society social cohesion challenges in the pandemic conditions of digitally mediated interactions. Based on the results of qualitative sociological research, as well as a secondary an...

Redressing COVID-19 vaccine inequity amidst booster doses: charting a bold path for global health solidarity, together

Abstract Background With large swathes of the world’s population—majority clustered in low- and middle-income countries—still yet to receive the minimum of two doses of the COVID-19 vaccine; The need to address the failures of international...