Academic Articles & Research Papers

Pregnancy complications and risk of cardiometabolic-renal conditions in 1.4 million women in England: longitudinal study.

Biopsy-Proven Glomerular Diseases in Saudi Arabia: The Clinicopathological Spectrum and Predictors of Renal Outcomes in a Single-Center Cohort and Four Decades of National Data.

Incidence and epidemiological characteristics of congenital adrenal hyperplasia in Hangzhou newborns, China (2014-2024): a population-based cross-sectional study.

Relative risk reduction is not enough: why cardiorenal trials should routinely report absolute risk reduction and number needed to treat.

Renal injury phenotypes with ICI-VEGFR-TKI combinations in renal cell carcinoma: active-comparator analyses in FAERS and JADER.

Developing European policy on xenotransplantation: instructive findings from the first representative UK sample survey on attitudes and views on animal to human transplants

Recent landmark advances, particularly those related to gene-editing technology and the pioneering pig-to-human transplants currently underway in the USA and China, mean that xenotransplantation (XTx) may become a realistic option for patie...

Postbiotics in Functional Foods: Preparation-Based Characterization, Gut–Brain Axis Interactions, and Translational Perspectives

Postbiotics are defined as preparations of inanimate microorganisms and/or their components that confer a health benefit on the host. Although interest in postbiotics has increased substantially, their translational use in functional foods ...

New Directions in Chronic Disease Management

A worldwide epidemic of chronic disease, and complications thereof, is underway, with no sign of abatement. Healthcare costs have increased tremendously, principally because of the need to treat chronic complications of non-communicable dis...

Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells

Abstract Background Foetal renal dysplasia is still the main cause of adult renal disease. Placenta-derived exosomes are an important communication tool, and they may play an important role in placental (both foetal and maternal) function. ...

Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition

The Taiwan Initiative for Geriatric Epidemiological Research (TIGER) was founded in 2011 to elucidate the interrelationships among various predictors of global and domain-specific cognitive impairment, with the aim of identifying older adul...

Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of diabetic kidney disease (DKD)

Abstract Diabetic kidney disease (DKD), a prevalent microvascular complication of diabetes, is a leading cause of chronic kidney disease and end-stage renal disease. Moreover, it plays a crucial role in the morbidity and mortality of diabet...

El estilo decorativo en las primeras producciones cerámicas en el valle del río Vinalopó (Alicante) / Decorative Style in Early Pottery Production of the Valley of Vinalopó river (Alicante)

n the present dissertation we study the Neolithic ceramic decorative style from the Vinalopó’s Valley and from the Early Neolithic chronology, based on a sample of six ceramic vases – from Cueva Santa, Arenal de la Virgen, Ledua, Alcudia an...

Generation of proximal tubule spheroids for nephrotoxicity assessment

Background To date, nephrotoxicity in new drug development has been evaluated through two-dimensional culture of representative cell lines, such as HK-2 and human proximal tubule epithelial cells (hPTECs). Approximately 20% of new drugs tha...

Effects of the Brazilian Native Fruit Jaboticaba (<i>Plinia cauliflora</i>) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models

Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...

Identification of functional pathways for regenerative bioactivity of selected renal cells

Abstract Background Selected renal cells (SRC) are in Phase II clinical trials as a kidney-sourced, autologous, tubular epithelial cell-enriched cell-based therapy for chronic kidney disease (CKD). In preclinical studies with rodent models ...

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

In cancer many gene variants may contribute to disease etiology, but the impact of a given gene variant may have varied effect size. Here, the authors analyse summary statistics of genome-wide association studies from fourteen cancers, and ...

The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey

Abstract Several studies have demonstrated the nephroprotective effects of estrogen on renal damage. In light of the inconsistent results of previous findings, this study aims to evaluate the in-depth role of menopausal hormone therapy (MHT...

The Role of Bone Marrow-Derived Mesenchymal Stromal Cells and Hesperidin in Ameliorating Nephrotoxicity Induced by Cisplatin in Male Wistar Rats

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) and antioxidants opened the way for many effective therapeutic experiments against damaged organs like kidneys. Nephrotoxicity is the main complication of chemotherapeutic drugs. There...

Coronary artery bypass grafting outcomes of patients with human immunodeficiency virus: a population-based study of National Inpatient Sample from 2015 to 2020

Abstract Individuals affected by human immunodeficiency virus (HIV) have a growing demand for coronary artery bypass grafting (CABG) due to heightened risk for cardiovascular diseases and extended life expectancy. However, CABG outcomes in ...

Profile of peginesatide and its potential for the treatment of anemia in adults with chronic kidney disease who are on dialysis

Ashraf MikhailRenal Unit, Morriston Hospital, Swansea University, Wales, UKAbstract: Peginesatide is a synthetic, dimeric peptide that is covalently linked to polyethylene glycol (PEG). The amino acid sequence of peginesatide is unrelated t...