Academic Articles & Research Papers

CBLL1 is highly expressed in non‐small cell lung cancer and promotes cell proliferation and invasion

Background Studies have shown that E3 ubiquitin ligase CBLL1 plays multiple roles in development and tumorigenesis. CBLL1 is over‐expressed in colon cancer and associated with cancer cell proliferation. While, the overexpression of CBLL1 in...

A cross-sectional assessment of knowledge, attitude, and practice of dentists regarding acute herpetic gingivostomatitis in children

Acute herpetic gingivostomatitis (AHGS) is the oral manifestation of HVS-1 primary infection. Despite being a self-limiting infection, AHGS can progress to severe complications. Dentists should be prepared to correctly diagnose and treat th...

Tungsten Oxide-contained PEO Coatings on Ti–6Al‑4 V Alloys: Enhanced Surface Characteristics and Bioactivity for Bio-implant

Intramucosal nevus on the posterior hard palate

Evaluating Adenomyosis with Transvaginal Sonography: Diagnostic Precision and Clinical Relevance

Background: Adenomyosis is an important benign gynecological condition among females with variable signs and symptoms. Prompt detection of suspicious cases is important for the effective management of the disease. The objective of the curre...

Adolescent victimization and psychosocial well-being in a Finnish population-based sample

ABSTRACTPotentially traumatizing events are common in adolescence, and these experiences have an impact on psychopathology. Furthermore, these events cumulate for certain individuals. More knowledge about the relationship between well-being...

Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat

Abstract Dispositional anxiety is a trait-like phenotype that confers increased risk for a range of debilitating neuropsychiatric disorders. Like many patients with anxiety disorders, individuals with elevated levels of dispositional anxiet...

Combined Effect of Silica Applications and Nitrogen Fertilizers on Two Rice Cultivars and Infestation Rate by Stem Borer, Chilo agamemnon Bles

Field experiments were conducted at Sakha, Kafr El-Sheikh, Egypt; to investigate the effect silica combined with mineral nitrogen on rice yield, and stem borer Chilo agamemnon Bles. Applying potassium ore combined with 92 kg N/fed. Produced...

BIOLOGICAL ASPECTS AND THERMAL REQUIREMENTS OF THE BIRD CHERRY-OAT APHID, Rhopalosiphum padi (LINNAEUS), REARED ON WHEAT SEEDLINGS

The bird cherry-oat aphid, Rhopalosiphum padi (Linnaeus) was studied at 15, 20 and 25oC constant temperatures. Wheat seedlings were offered for feeding and maintaining the aphid, R. padi using the Punctured Ependorf Tube Technique. R. padi ...

Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability

Doublecortin-like kinase 1 (DCLK1) is a serine/threonine-kinase with two doublecortin (DCX) domains. DCLK1 is associated with microtubules via DCX domains and regulates microtubule polymerization. DCLK1 is known to be expressed in cancer st...

Mechanistic insights into TAM-mediated OMP assembly in Gram-negative bacteria

Summary: The β-barrel assembly machinery (BAM) is essential for outer membrane protein (OMP) biogenesis in Gram-negative bacteria and represents a validated target for antibiotic development. Its evolutionary relative, the translocation and...

Effects of the Brazilian Native Fruit Jaboticaba (<i>Plinia cauliflora</i>) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models

Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...

Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19

Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a ...

Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy

Background. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect ...

RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.

Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels o...

CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase

ObjectiveExtranodal natural killer/T cell lymphoma (NKTCL) is an aggressive EBV-related lymphoma, originating from NK cells or T cells. Previous study demonstrated that CD56 negative NKTCL should be recognized as a distinct subtype. In this...

Are museums the future of evolutionary medicine?

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

In cancer many gene variants may contribute to disease etiology, but the impact of a given gene variant may have varied effect size. Here, the authors analyse summary statistics of genome-wide association studies from fourteen cancers, and ...

The High Frequency of a G-Allele Variant of the <i>FOXP3</i> Gene in Old Asian Cattle Breeds, Water Buffaloes, and Holstein Friesian Cows: A Potential Link to Infertility

Reproductive failure in cattle production is a global concern and is influenced by various factors, including genetic alterations. This study explored the relationship between an X-linked single-nucleotide variant (NC_037357.1: g.87298881A>...

Acute exposure to copper oxide nanoparticles impairs testicular function and sperm quality in adult male albino rats

Copper oxide nanoparticles (CuO NPs) are metallic nanoparticles fulfilling several functions such as good conductivity, catalyst, used in sensors and energy storage devices, and antibacterial characteristics. However, the cytotoxicity and...