Academic Articles & Research Papers

Ocular manifestations in autism spectrum disorder

Autism spectrum disorder (ASD) represents a neurodevelopmental disorder that has been the focus of numerous studies on the central nervous system (CNS). The embryological origin of the brain and retina is shared, with the axons of retinal g...

White matter structural changes in the visual pathway of thyroid-associated ophthalmopathy patients: a free water and multi-shell diffusion imaging study

BackgroundCompared to single-shell diffusion tensor imaging (DTI), free water (FW) and neurite orientation dispersion and density imaging (NODDI) offer a more comprehensive evaluation of microstructural alterations in cerebral white matter ...

Nanotechnology in ophthalmology

Nanotechnology and its Applications in Medicine

Nanotechnologyis the study of extremely small structures, having size of 0.1 to 100 nm. Nano medicine is a relatively new field of science and technology. Brief explanation of various types of pharmaceutical nano systems is given. Classific...

Contrast Sensitivity Is Associated With Chorioretinal Thickness and Vascular Density of Eyes in Simple Early-Stage High Myopia

ObjectiveTo evaluate the contrast sensitivity function (CSF), chorioretinal thickness and vascular density as well as their relationships in subjects with simple early-stage high myopia.MethodsEighty-one young subjects were enrolled in this...

Un nouveau cachet à collyres découvert à Reims/Durocortorum

A new eyedrop cachet was discovered during the excavation of the aquatic complex of Reims by Inrap in 2018. It presents exceptional morphological and epigraphic features. Like the majority of the other 365 eyedrop cachets recorded to date, ...

Impact of prolonged obstructive sleep apnea syndrome disease course on retinal-choroidal microcirculation: a WF-SS-OCTA study

Purpose: This study used wide-field swept-source optical coherence tomography angiography (WF-SS-OCTA) to evaluate changes in macular vascular density in patients with obstructive sleep apnea syndrome (OSAS) at different stages of disease d...

Timing of menarche and pubertal growth patterns using the QEPS growth model

ObjectivesTo explore the timing of menarche, postmenarcheal growth, and to investigate the impact of various variables on menarcheal age and postmenarcheal and pubertal growth.Study DesignThis longitudinal community population-based study a...

Phase 2a/b randomised placebo-controlled dose-escalation trial of triheptanoin for ataxia-telangiectasia: treating mitochondrial dysfunction with anaplerosisResearch in context

Summary: Background: Ataxia-telangiectasia (A-T) is a rare multisystem disease characterised by neurodegenerative cerebellar ataxia, lung disease, immune deficiency, high cancer risk, and mitochondrial dysfunction. A-T cells demonstrate de...

Knowledge, attitude, and practice patterns of Indian ophthalmologists regarding medicolegal issues

Purpose: To assess the knowledge, attitude, and practice patterns (KAPP) of Indian ophthalmologists regarding medicolegal issues using an initial survey. Methods: An online form was circulated among Indian ophthalmologists of all ages over ...

Exploring resilience among hospital workers: a Bayesian approach

Background and importanceHealthcare professionals face significant workloads, as their roles are among the most demanding and stressful. Resilience serves as a crucial factor in helping them cope with the challenges encountered in their wor...

Conjunctival lymphangioma in a 4-year-old girl revealed tuberous sclerosis complex

Background: To present a case of conjunctival lymphangioma in a girl with tuberous sclerosis complex.Methods/results: A 4-year-old girl presented with a relapsing cystic lesion of the bulbar conjunctiva in the right eye with string-of-pear...

NLRP3 Inflammasome-Mediated Pyroptosis Pathway Contributes to the Pathogenesis of Candida albicans Keratitis

PurposeFungal keratitis is a sight-threatening corneal infection caused by fungal pathogens, and the pathogenic mechanisms have not been fully elucidated. The aim of this study was to determine whether NOD-like receptor family pyrin domain ...

Melanopsin and Cone Photoreceptor Inputs to the Afferent Pupil Light Response

Background: Retinal photoreceptors provide the main stage in the mammalian eye for regulating the retinal illumination through changes in pupil diameter, with a small population of melanopsin-expressing intrinsically photosensitive retinal ...

Medical, dental, and nursing students’ attitudes and knowledge towards artificial intelligence: a systematic review and meta-analysis

Abstract Background Nowadays, Artificial intelligence (AI) is one of the most popular topics that can be integrated into healthcare activities. Currently, AI is used in specialized fields such as radiology, pathology, and ophthalmology. Des...

Early Retinal Microvascular Alterations in Young Type 1 Diabetic Patients without Clinical Retinopathy

The purpose of this study is to identify and quantify preclinical changes with the help of optical coherence tomography angiography (OCTA) within the retinal microcirculation of young type 1 diabetes (T1D) patients without clinical signs of...

Income and education predict elevated depressive symptoms in the general population: results from the Gutenberg health study

Abstract Background Socioeconomic status (SES) has a strong association with depression or physical and mental health in general. However, as SES is a multifaceted construct these associations are not easy to explain. Further, there are sev...

Evaluating an LLM-assisted workflow for clinical documentation: A pilot randomized controlled trial on time and quality.

Large language models (LLMs) have been investigated for clinical documentation, with concerns about hallucinations and factual errors. Clinician review and revision of LLM-generated drafts are considered essential; however, the impact of su...

Cuba's Community Health Services：Introduction and Implications to China

Cuba has a three-level healthcare system, and offers free universal healthcare, of which community health services occupy a decisive position. Cuba has accumulated abundant experience in implementing public health services, primary healthca...

Necroptosis and Neuroinflammation in Retinal Degeneration

Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated i...