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Showing 11 of 31 academic articles

Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold

Angelo Corti, Angelina Sacchi, Anna Maria Gasparri, Matteo Monieri et al. • Journal of Nanobiotechnology (2021)

Abstract Background Gold nanospheres tagged with peptides containing isoDGR (isoAsp-Gly-Arg), an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor vasculature. We prepared bi- o...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-021-00871-y

Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern

Callum M Ives, Linh Nguyen, Carl A Fogarty, Aoife M Harbison et al. • eLife (2024)

Glycosylation of the SARS-CoV-2 spike (S) protein represents a key target for viral evolution because it affects both viral evasion and fitness. Successful variations in the glycan shield are difficult to achieve though, as protein glycosyl...

DOAJ Open Access (DOAJ) DOI: 10.7554/eLife.95708

Crystal structure and Hirshfeld surface analysis of 4-allyl-2-methoxy-6-nitrophenol

Yassine El Ghallab, Sanae Derfoufi, El Mostafa Ketatni, Mohamed Saadi et al. • Acta Crystallographica Section E: Crystallographic Communications (2020)

The asymmetric unit of the title compound, C10H11NO4, which was synthesized via nitration reaction of eugenol (4-allyl-2-methoxyphenol) with a mixture of nitric acid and sulfuric acid, consists of three independent molecules of similar geom...

DOAJ Open Access (DOAJ) DOI: 10.1107/S2056989020002601

Understanding the regulatory grammar of sepsis-causing Staphylococcus aureus bacteria using contexualised DNA language models

Tyrone Chen, Anton Y. Peleg, Sonika Tyagi • Scientific Reports (2025)

Abstract To efficiently and accurately understand, detect, and treat sepsis, we require a deep understanding of how its underlying biological systems work. Conventional methods struggle to provide a detailed view of both the functional and ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-16701-2

Contagions

Paolo Pepe • Testo & Senso (2022)

A hundred years separate two of the most successful masterpieces of English Gothic Fiction: The Monk (1796) by Matthew Gregory Lewis and Dracula (1897) by Bram Stoker. The significance of this circumstance goes beyond the mere chronological...

DOAJ Open Access (DOAJ)

How structure determines correlations in neuronal networks.

Volker Pernice, Benjamin Staude, Stefano Cardanobile, Stefan Rotter • PLoS Computational Biology (2011)

Networks are becoming a ubiquitous metaphor for the understanding of complex biological systems, spanning the range between molecular signalling pathways, neural networks in the brain, and interacting species in a food web. In many models, ...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pcbi.1002059

Design of a TSR-based project learning strategy for biochemistry undergraduate teaching and research labs: a case study

Camille R. Reaux, Shelby A. Meche, Jordan M. Grider, Soundharya Dhanabal et al. • Frontiers in Education (2025)

Given the exponential growth of biochemical data and deep effect of computational methods on life sciences, there is a need to rethink undergraduate curricula. A project-oriented learning approach based on the Triangular Spatial Relationshi...

DOAJ Open Access (DOAJ) DOI: 10.3389/feduc.2024.1455173

MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites

Chengqi Wang, Yibo Dong, Chang Li, Jenna Oberstaller et al. • Genome Biology (2023)

Abstract Malaria remains one of the deadliest infectious diseases. Transcriptional regulation effects of noncoding variants in this unusual genome of malaria parasites remain elusive. We developed a sequence-based, ab initio deep learning f...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13059-023-03063-z

Text Data Augmentation for Deep Learning

Connor Shorten, Taghi M. Khoshgoftaar, Borko Furht • Journal Of Big Data (2021)

Natural Language Processing (NLP) is one of the most captivating applications of Deep Learning. In this survey, we consider how the Data Augmentation training strategy can aid in its development. We begin with the major motifs of Data Augme...

OPENALEX cc-by DOI: https://doi.org/10.1186/s40537-021-00492-0 PMC: 8287113