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Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells

Mengqi Gu, Pengzheng Chen, Dongmei Zeng, Xiaotong Jiang et al. • Cell Communication and Signaling (2023)

Abstract Background Foetal renal dysplasia is still the main cause of adult renal disease. Placenta-derived exosomes are an important communication tool, and they may play an important role in placental (both foetal and maternal) function. ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12964-023-01286-y

Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

Tara Jois, Weiyi Chen, Victor Howard, Rebecca Harvey et al. • Molecular Metabolism (2017)

Objective: Carbohydrate response element binding protein (ChREBP) is a transcription factor that responds to glucose and activates genes involved in the glycolytic and lipogenic pathways. Recent studies have linked adipose ChREBP to insulin...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.molmet.2017.07.006

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice

Devin Wahl, Samantha M. Solon-Biet, Qiao-Ping Wang, Jibran A. Wali et al. • Cell Reports (2018)

Summary: Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-protein, high-carbohydrate (LPHC) diets also extend lifespan, but it is not known whether they are beneficial for brain health. We compar...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.celrep.2018.10.070

Correlation between sarcopenia and changes in oligodendrocyte lineage cells in the brains of Alzheimer's disease model mice

Lin-lin Yao, Xiao-ting Ma, Fang-bo Li, Lin-yi Zheng et al. • Experimental Gerontology (2026)

Background: Alzheimer's disease (AD) is a neurodegenerative disorder primarily characterized by cognitive dysfunction. The discovery and identification of non-cognitive symptoms in the preclinical stage hold promise for early diagnosis and ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2026.113057

Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics

Junqi Yang, Yumin Ma, Jiang Liu, Qingtian Zhu et al. • Experimental Gerontology (2024)

The aging of pancreatic beta cells is closely associated with various diseases, such as impaired glucose tolerance, yet the underlying regulatory mechanisms remain unclear. In this study, we screened young and aged mouse pancreatic beta cel...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2024.112633

Measurement of the Y(1S) pair production cross section and search for resonances decaying to Y(1S)μ+μ− in proton-proton collisions at s=13TeV

A.M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi et al. • Physics Letters B (2020)

The fiducial cross section for Y(1S) pair production in proton-proton collisions at a center-of-mass energy of 13 TeV in the region where both Y(1S) mesons have an absolute rapidity below 2.0 is measured to be 79±11(stat)±6(syst)±3(B)pb ass...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.physletb.2020.135578

REVIEW OF MODERN APPROACHES TO DENTAL FLUOROSIS MANAGEMENT

L.F. Kaskova, N.A. Morhun, L.I. Amosova, N.V. Yanko et al. • Український стоматологічний альманах (2019)

Dental fluorosis is caused by ingesting too much fluoride while the teeth are developing. Poltava region belongs to Buchach fluorine hydrogeological province which ground waters are characterized by a high content of fluorine. Such district...

DOAJ Open Access (DOAJ) DOI: 10.31718/2409-0255.3.2019.11

Structural Design, Synthesis and Antioxidant, Antileishmania, Anti-Inflammatory and Anticancer Activities of a Novel Quercetin Acetylated Derivative

Saul Vislei Simões da Silva, Orlando Maia Barboza, Jéssica Teles Souza, Érica Novaes Soares et al. • Molecules (2021)

Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological use. The aim of this study was to perform structural mod...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules26226923