Academic Articles & Research Papers

Effect of probiotics on cognitive function and cardiovascular risk factors in mild cognitive impairment and Alzheimer’s disease: an umbrella meta-analysis

Abstract Background This umbrella meta-analysis evaluates the effects of probiotics on cognitive function and metabolic health in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) by synthesizing findings from meta-analyses of ra...

Risk Profiles for Falls among Older Adults: New Directions for Prevention

ObjectiveTo address whether neighborhood factors, together with older adults’ levels of health and functioning, suggest new combinations of risk factors for falls and new directions for prevention. To explore the utility of Grade-of-Members...

The burden and determinants of cognitive impairment among individuals with chronic diseases in Ethiopia: A systematic review and meta-analysis

Introduction: Cognitive impairment is a medical condition caused by neurodegeneration, marked by a gradual decline in neurological, motor, psychological, and cognitive domain functions, as well as daily activities. It primarily affects indi...

The features analysis of hemoglobin expression on visual information transmission pathway in early stage of Alzheimer’s disease

Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized primarily by cognitive impairment. The motivation of this paper is to explore the impact of the visual information transmission pathway (V–H pathway) on AD, and...

Mapping the acute trajectory of sport-related concussion outcomes across symptoms, cognition, and blood biomarkers

Sport-related concussion (SRC) and its potential neurological sequela represent an emerging global health concern, requiring improved recovery management and strategies for return-to-play (RTP) to enhance brain health in athletes. Given the...

Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau

Mild cognitive impairment (MCI) can be an early manifestation of Alzheimer’s disease (AD) pathology, other pathologic entities [e.g., cerebrovascular disease, Lewy body disease, LATE (limbic-predominant age-related TDP-43 encephalopathy)], ...

Disrupted Functional Connectivity of Cornu Ammonis Subregions in Amnestic Mild Cognitive Impairment: A Longitudinal Resting-State fMRI Study

Background: The cornu ammonis (CA), as part of the hippocampal formation, represents a primary target region of neural degeneration in amnestic mild cognitive impairment (aMCI). Previous studies have revealed subtle structural deficits of t...

Digital Exclusion and Cognitive Function in Elderly Populations in Developing Countries: Insights Derived From 2 Longitudinal Cohort Studies

BackgroundCognition disorders not only lead to adverse health consequences but also contribute to a range of socioeconomic challenges and diminished capacity for performing routine daily activities. In the digital era, understanding the imp...

Neural substrates of motor and cognitive dysfunctions in SCA2 patients: A network based statistics analysis

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease characterized by a progressive cerebellar syndrome, which can be isolated or associated with extracerebellar signs. It has been shown that patients affe...

The South African Society of Psychiatrists (SASOP) and SASOP State Employed Special Interest Group (SESIG) position statements on psychiatric care in the public sector

Executive summary. National mental health policy: SASOP extends its support for the process of formalising a national mental health policy as well as for the principles and content of the current draft policy. Psychiatry and mental health...

Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study

BackgroundConstipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close...

Resting-state EEG measures cognitive impairment in Parkinson’s disease

Abstract Cognitive dysfunction is common in Parkinson’s disease (PD). We developed and evaluated an EEG-based biomarker to index cognitive functions in PD from a few minutes of resting-state EEG. We hypothesized that synchronous changes in ...

Factors associated with advance directive completion among older adults with and without cognitive impairment: a nationwide cross-sectional study.

Evaluating the accuracy of brief cognitive assessments for the early detection of cognitive impairment in adults across primary and specialty care settings: A systematic review and meta-analysis.

Improving cognitive impairment classification in Alzheimer’s disease using tabular diffusion augmentation and late fusion deep learning.

Gut Microbiota and Targeted Biomarkers Analysis in Patients With Cognitive Impairment

Gut microbial alteration is closely associated with brain disorders including cognitive impairment (CI). Gut microbes have the potential to predicate the development of diseases. However, the gut microbial markers for CI remain to be elucid...

Machine learning in pain research

1. Introduction Pain and pain chronification are incompletely understood and unresolved medical problems that continue to have a high prevalence.14 It has been accepted that pain is a complex phenomenon.2,32,72 Contemporary methods of compu...

Use of machine learning algorithms to determine the relationship between air pollution and cognitive impairment in Taiwan

Air pollution has become a major global threat to human health. Urbanization and industrialization over the past few decades have increased the air pollution. Plausible connections have been made between air pollutants and dementia. This st...

PERMEPSY: a multicentre, randomized, double-blind proof-of-concept trial of personalized metacognitive training for adults with psychosis — a study protocol

BackgroundWhile psychological interventions are effective at improving symptoms of psychosis, accessible, cost- and time-efficient treatments remain limited. Personalized medicine has emerged as a promising approach, tailoring interventions...