Academic Articles & Research Papers

Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro

Colorectal carcinoma (CRC) is one of the most common malignancies, though there are no effective therapeutic regimens at present. This study aimed to investigate the inhibitory effects of mannooligosaccharides extracted from coconut meal (C...

Effectiveness of Back care education Programme among school children: a systematic review of randomized controlled trials

Abstract Study design Systematic review of Randomised controlled trials. Objectives With the increasing incidence of back pain among children and its untold implications to their future, back education tailored in an effective way would be ...

Health technology, quality and safety in a learning health system

Health technology quality and safety is an important issue for health informatics (i.e. digital health) professionals. Health technologies have been used to (1) collect data that can be analyzed to improve the quality and safety of healthca...

A taxonomy of model structures for economic evaluation of health technologies

Models for the economic evaluation of health technologies provide valuable information to decision makers. The choice of model structure is rarely discussed in published studies and can affect the results produced. Many papers describe good...

Health technology innovations

The global pandemic has drastically impacted older adults in numerous ways (e.g., loneliness; age discrimination; mental and physical health; limited access to traditional health care).On the other hand, it may have accelerated the general ...

Methods in health service research: An introduction to bayesian methods in health technology assessment

Methods in health service research: An introduction to bayesian methods in health technology and assessment...

The new definition of health technology assessment: A milestone in international collaboration

BACKGROUND: An international joint task group co-led by the International Network of Agencies for Health Technology Assessment (INAHTA) and Health Technology Assessment International (HTAi) has developed a new and internationally accepted d...

Effects of an infant formula containing a whey protein concentrate on feeding tolerance and markers of intestinal immune defense in Chinese infants

Abstract Background Human milk (HM) bioactive components can have immune modulatory functions, impact the gut microbiome, and may result in functional benefits when added to infant formula (IF). In this single-arm, prospective, intervention...

The change of gut microbiota in MDD patients under SSRIs treatment

Abstract The alterations in the gut microbiota have been reported to be correlated with the development of depression. The purpose of this study was to investigate the changes of intestinal microbiota in depressed patients after antidepress...

Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved]

Background Breast cancer remains a significant global health concern, with early diagnosis and risk factor identification crucial for improving outcomes. Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) measurements...

The effects of women's empowerment on the nutritional status of children in Nigeria using the 2018 demographic health survey

Objectives: The empowerment of women critically influences child nutrition in Nigeria, where malnutrition remains a major public health challenge. This study examines the relationship between dimensions of women’s empowerment, economic, edu...

From Health Technology Assessment to Health Technology Sustainability

This paper aims to propose a methodological lens to the assessment of technological innovations in healthcare based on the principles of social, economic, and political sustainability. Starting from the consideration of a lack of a unified ...

On value-judgements and ethics in health technology assessment

Health technology assessment

User-Centered Design and Interactive Health Technologies for Patients

Despite recommendations that patients be involved in the design and testing of health technologies, few reports describe how to involve patients in systematic and meaningful ways to ensure that applications are customized to meet their need...

Real World Data in Health Technology Assessment of Complex Health Technologies

The available evidence on relative effectiveness and risks of new health technologies is often limited at the time of health technology assessment (HTA). Additionally, a wide variety in real-world data (RWD) policies exist among HTA organiz...

The Downregulation of eIF3a Contributes to Vemurafenib Resistance in Melanoma by Activating ERK via PPP2R1B

Vemurafenib, a BRAF V600E inhibitor, provides therapeutic benefits for patients with melanoma, but the frequent emergence of drug resistance remains a challenge. An understanding of the mechanisms underlying vemurafenib resistance may gener...

Robotic-assisted anatomic anterior cruciate ligament reconstruction: a comparative analysis of modified transtibial and anteromedial portal techniques in cadaveric knees

Introduction: This study employed surgical robot to perform anatomic single-bundle reconstruction using the modified transtibial (TT) technique and anteromedial (AM) portal technique. The purpose was to directly compare tunnel and graft cha...

Molecular Informatics, Chemometrics, and Sensory Omics for Constructing an Umami Peptide Cluster Library Across the Entire Lager Beer Brewing Process

Umami taste in lager beer not only determined body fullness and the backbone of aftertaste, but also affected the controllability and interpretability of flavor expression across the entire brewing process. Based on stage-wise sampling, pep...

Physical, psychological and behavioural responses of aircraft occupants to volcanic emissions

Abstract Volcanic eruptions produce plumes of ash, gas and aerosols that present a risk to aviation at all standard flight levels. Here, we investigate atmospheric dispersal of volcanic emissions, whether and how they infiltrate aircraft, a...