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Gamma-irradiated SARS-CoV-2 vaccine candidate, OZG-38.61.3, confers protection from SARS-CoV-2 challenge in human ACEII-transgenic mice

Raife Dilek Turan, Cihan Tastan, Derya Dilek Kancagi, Bulut Yurtsever et al. • Scientific Reports (2021)

Abstract The SARS-CoV-2 virus caused the most severe pandemic around the world, and vaccine development for urgent use became a crucial issue. Inactivated virus formulated vaccines such as Hepatitis A and smallpox proved to be reliable appr...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-021-95086-4

CD36‐Binding Amphiphilic Nanoparticles for Attenuation of α‐Synuclein‐Induced Microglial Activation

Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych et al. • Advanced NanoBiomed Research (2022)

Neuroinflammation is one of the hallmarks contributing to Parkinson's disease (PD) pathology, where microglial activation occurs as one of the earliest events, triggered by extracellular α‐synuclein (aSYN) binding to the cluster of differen...

DOAJ Open Access (DOAJ) DOI: 10.1002/anbr.202100120

Peptide-functionalized periodic mesoporous silica nanoparticles for monocyte-specific TET3 Silencing enhance cardiac repair after acute myocardial infarction

Hao Jin, Jiandong Ding, Xiaoguo Zhang, Shouquan Cheng et al. • Journal of Nanobiotechnology (2025)

Abstract Modulating the balance between pro- and anti-inflammatory monocyte subsets holds therapeutic promise in acute myocardial infarction (AMI); however, effective and selective strategies are still lacking. In this study, we are the fir...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03782-4

The antibiogram of Pus cultures in Federal Tertiary Care Hospital, Islamabad and its utility in antimicrobial stewardshipThe antibiogram of pus cultures in federal tertiary care hospital, Islamabad and its utility in antimicrobial stewardship

Farhan Kursheed, Asraar Tabassum, Umme Farwa, Samia Wazir et al. • Iranian Journal of Microbiology (2024)

Background and Objectives: Antimicrobial resistance has emerged as a significant global health threat. Infections caused by Multi Drug-Resistant (MDR) bacteria pose formidable challenges in terms of treatment options and patient outcomes. P...

DOAJ Open Access (DOAJ) DOI: 10.18502/ijm.v16i1.14871

Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia

Chih-Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann-Tarng Jou et al. • Scientific Reports (2023)

Abstract Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, espec...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-023-27720-2

The Advancement of Medical Biotechnology in Developing Countries: Economic Opportunities and Challenges

Jiawen Chen • Highlights in Business Economics and Management (2023)

Starting from decades ago, medical biotechnology has revolutionized the healthcare industry by offering new hopes for previously untreatable diseases and improving overall health outcomes. To explore the advancements in medical biotechnolog...

OPENALEX cc-by-nc DOI: https://doi.org/10.54097/45c92q28

Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms

Xiao Wang, Wenxuan Shi, Yu Jin, Zhuoyuan Li et al. • Journal of Nanobiotechnology (2025)

Abstract The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03126-2

Isolation, characterization, and genomic analysis of a novel phage WSPA with lytic activity against Serratia marcescens

Lijuan Li, Kunkun Li, Yu Mi, Xiumei Wu et al. • Microbiology Spectrum (2025)

ABSTRACT Serratia marcescens is an established pathogen implicated in hospital-acquired infections and is notorious for its propensity to form biofilms on medical devices, leading to persistent environmental contamination and increased infe...

DOAJ Open Access (DOAJ) DOI: 10.1128/spectrum.02716-24

Prevalence of Obesity and Malnutrition among School-Aged Children of the District Peshawar

Usman Shah1, Usman Saeed2, Maryam Bibi3,, , Shakir Ullah3 et al. • Egyptian Journal of Nutrition (2024)

ABSTRACTMalnutrition and Obesity are worldwide health phenomena so the aims of the study were to assist the prevalence of obesity and malnutrition among school-aged children of the district Peshawar. Institutional based cross-sectional stud...

DOAJ Open Access (DOAJ) DOI: 10.21608/enj.2024.391626

Current Evidence on Gene-Based and Epigenetic Therapeutic, Diagnostic, and Prognostic Strategies in Epithelial-Derived Carcinomas: A Scoping Review

Joshua George Thomas, Mohammed Ayyub, Lovely M. Annamma, Prathibha Prasad et al. • Biomedicines (2026)

Background: Epithelial-derived carcinomas exhibit genomic instability due to genetic mutation and epigenetic dysregulation. Mechanisms such as DNA methylation, histone modifications, and noncoding RNA regulation may lead to tumor progressio...

DOAJ Open Access (DOAJ) DOI: 10.3390/biomedicines14102234

Lipidomic Analysis of Caenorhabditis elegans Embryos

Hung-Chi Yang, Cheng-Yu Hung, Yi-Yun Pan, Szecheng Lo et al. • Bio-Protocol (2017)

Metabolomic is an emerging field of system biology. Lipidomic, a branch of metabolomic, aims to characterize lipophilic metabolites in biological systems. Caenorhabditis elegans (C. elegans) is a genetically tractable and versatile animal m...

DOAJ Open Access (DOAJ) DOI: 10.21769/BioProtoc.2554

Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases

Lateef Adegboyega Sulaimon, Lukman Olalekan Afolabi, Rahmat Adetutu Adisa, Akinrinade George Ayankojo et al. • Advances in Redox Research (2022)

The Mitochondria is a critical sub-cellular organelle that plays an integral part in a normal cellular process. Besides ATP production, the mitochondria participate in various key cellular processes such as cell signaling, epigenetic regula...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.arres.2022.100037

Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of IK(M) or IK(DR) and in the Stimulation of IMEP

Wei-Ting Chang, Wei-Ting Chang, Wei-Ting Chang, Ping-Yen Liu et al. • Frontiers in Pharmacology (2020)

Remdesivir (RDV, GS-5734), a broad-spectrum antiviral drug in the class of nucleotide analogs, has been particularly tailored for treatment of coronavirus infections. However, to which extent RDV is able to modify various types of membrane ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2020.01091

CDC25A inhibition sensitizes melanoma cells to doxorubicin and NK cell therapy

Xinyue Gao, Feichang Liu, Bo Zhang, Tianyi Ren et al. • Cell Death and Disease (2025)

Abstract Cell division cycle 25 (CDC25) phosphatases serve as crucial regulators of cell cycle phase transitions and essential components of the checkpoint machinery involved in DNA damage response. Emerging evidence indicates the oncogenic...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41419-025-07598-w

NEP1-40-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury

Yan Lin, Chunhong Li, Jian Li, Ruolan Deng et al. • Journal of Nanobiotechnology (2019)

Abstract Background Frequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes an...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-019-0449-3