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Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study

Fei Wang, Fei Wang, Min Fei, Min Fei et al. • Frontiers in Neuroscience (2022)

BackgroundConstipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2021.821654

Neuroscience in Medicine

P. Michael Conn • Humana Press eBooks (2003)

Cytology and Organization of Cell Types: Light and Electron Microscopy Rochelle S. Cohen and Donald W. Pfaff Anatomy of the Spinal Cord and Brain Bruce E. Maley Ion Channels and Electrical Signaling Stanko S. Stojilkovic A. Clinical Correla...

OPENALEX DOI: https://doi.org/10.1007/978-1-59259-371-2

Increased Postural Demand Is Associated With Greater Cognitive Workload in Healthy Young Adults: A Pupillometry Study

Melike Kahya, Tyler A. Wood, Jacob J. Sosnoff, Hannes Devos • Frontiers in Human Neuroscience (2018)

Introduction: Balance tasks require cognitive resources to ensure postural stability. Pupillometry has been used to quantify cognitive workload of various cognitive tasks, but has not been studied in postural control. The current investigat...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnhum.2018.00288

Specificity Protein 1: A Protein With a Two-Sided Role in Ischemic Stroke

Qinyang Yu, Qinyang Yu, Wangyang Liu, Wangyang Liu et al. • Frontiers in Cellular Neuroscience (2021)

Stroke is one of the leading causes of death and disability worldwide. However, there is a lack of effective medications to speed up the recovery process. Ischemic stroke, as the result of cerebral infarction or cerebral artery narrowing, i...

DOAJ Open Access (DOAJ) DOI: 10.3389/fncel.2021.757670

Evaluation of the SH-SY5Y cell line as an in vitro model for potency testing of a neuropeptide-expressing AAV vector

Jeanette Zanker, Daniela Hüser, Adrien Savy, Sara Lázaro-Petri et al. • Frontiers in Molecular Neuroscience (2023)

Viral vectors have become important tools for basic research and clinical gene therapy over the past years. However, in vitro testing of vector-derived transgene function can be challenging when specific post-translational modifications are...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2023.1280556

Emerging Role of Ferroptosis in the Pathogenesis of Ischemic Stroke: A New Therapeutic Target?

Zhong-Qi Bu, Hai-Yang Yu, Jue Wang, Xin He et al. • ASN Neuro (2021)

Ischemic stroke is one of the main causes of high morbidity, mortality, and disability worldwide; however, the treatment methods are limited and do not always achieve satisfactory results. The pathogenesis of ischemic stroke is complex, def...

DOAJ Open Access (DOAJ) DOI: 10.1177/17590914211037505

Fipronil disturbs the antigen-specific immune responses and GABAergic gene expression in the ovalbumin-immunized BALB/c mice

Jui-Fang Kuo, Yin-Hua Cheng, Chun-Wei Tung, Chia-Chi Wang • BMC Veterinary Research (2024)

Abstract Background Fipronil (FPN) is a broad-spectrum pesticide and commonly known as low toxicity to vertebrates. However, increasing evidence suggests that exposure to FPN might induce unexpected adverse effects in the liver, reproductiv...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12917-024-03878-3

The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis

Sebastian Makuch, Kamil Więcek, Marta Woźniak • Pharmaceuticals (2021)

Rheumatoid arthritis (RA) is a widespread chronic autoimmune disorder affecting the joints, causing irreversible cartilage, synovium, and bone degradation. During the course of the disease, many immune and joint cells are activated, causing...

DOAJ Open Access (DOAJ) DOI: 10.3390/ph14040309

Liposomal Neostigmine Bromide: A Localized Therapeutic Approach for Detrusor Underactivity

Kunpeng Liu, Haitao Gong, Binbin Jiao, Zhenshan Ding et al. • Advanced NanoBiomed Research (2024)

This study aims to evaluate the therapeutic potential of cationic liposomal neostigmine bromide (NB), a novel drug delivery system, for the treatment of detrusor underactivity. By comparing the characteristics of NB‐liposomes (NLP), NB‐β‐cy...

DOAJ Open Access (DOAJ) DOI: 10.1002/anbr.202300109

Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma

Zelin Tian, Chen Xu, Peijun Yang, Zhibin Lin et al. • Frontiers in Immunology (2022)

Hepatocellular carcinoma(HCC) is the sixth most common cancer in the world and is usually caused by viral hepatitis (HBV and HCV), alcoholic, and non-alcoholic fatty liver disease(NAFLD). Viral hepatitis accounts for 80% of HCC cases worldw...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2022.984728

Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives

Yao Li, Qiu Chen, Tingting Wang, Zengkai Ji et al. • Journal of Nanobiotechnology (2025)

Abstract As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, the search for more effective and convenient treatments has become a crucial issue in medical research. Microneedles (MNs), as an innovative dru...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03432-9

Soil Geochemical Properties Influencing the Diversity of Bacteria and Archaea in Soils of the Kitezh Lake Area, Antarctica

Qinxin Li, Nengfei Wang, Wenbing Han, Botao Zhang et al. • Biology (2022)

It is believed that polar regions are influenced by global warming more significantly, and because polar regions are less affected by human activities, they have certain reference values for future predictions. This study aimed to investiga...

DOAJ Open Access (DOAJ) DOI: 10.3390/biology11121855

Emerging mutations in envelope protein of SARS-CoV-2 and their effect on thermodynamic properties

Kejie Mou, Mohnad Abdalla, Dong Qing Wei, Muhammad Tahir Khan et al. • Informatics in Medicine Unlocked (2021)

Structural proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are potential drug targets due to their role in the virus life cycle. The envelope (E) protein is one of the structural proteins; plays a critical role in v...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.imu.2021.100675

Computational Tools; Indispensable Armamentarium of Medical Biotechnology

Nutan, Swapnil Jain, K Shilpa, Akanksha Tomar et al. • Indian Journal of Science and Technology (2016)

Objective: Computational infrastructure of medical biotechnology provides insight into elements of genomics, proteomics for understanding diseases and biological systems in a more comprehensive and systematic way. The present study exclusiv...

OPENALEX cc-by DOI: https://doi.org/10.17485/ijst/2016/v9i32/100745

Students' knowledge of, and attitudes towards biotechnology revisited, 1995–2014: Changes in agriculture biotechnology but not in medical biotechnology

Shao‐Yen Chen, Yih‐Ru Chu, Chen‐Yung Lin, Tzen‐Yuh Chiang • Biochemistry and Molecular Biology Education (2016)

Modern biotechnology is one of the most important scientific and technological revolutions in the 21st century, with an increasing and measurable impact on society. Development of biotechnology curriculum has become important to high school...

OPENALEX DOI: https://doi.org/10.1002/bmb.20969

Antibacterial and antioxidant effects of Punicalagin extracts from Punica granatum peels

Saidakhon T. Islamova, Moxira A. Nazarova, Aktam U. Burkhanov, Fayzulla Khamraev et al. • Caspian Journal of Environmental Sciences (2025)

The growing recognition of the health-promoting potential of compounds derived from natural sources, particularly those exhibiting antimicrobial and antioxidant activities, has resulted in a surge of research publications dedicated to explo...

DOAJ Open Access (DOAJ) DOI: 10.22124/cjes.2025.8570