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Atorvastatin suppresses high-risk colorectal adenomas via reprogramming of lipid metabolism and Inhibition of stemness

Wentong Chen, Mengxiao Ge, Shuangyi Sun, Hanxiao Zhang et al. • Scientific Reports (2025)

Abstract As critical precursors to colorectal cancer (CRC), high-risk colorectal adenomas (HR-CRAs) lack effective chemopreventive strategies beyond endoscopic resection. We previously established a standardized protocol for culturing patie...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-32406-y

Constraining PERMANOVA and LDM to within-set comparisons by projection improves the efficiency of analyses of matched sets of microbiome data

Zhengyi Zhu, Glen A. Satten, Caroline Mitchell, Yi-Juan Hu • Microbiome (2021)

Abstract Background Matched-set data arise frequently in microbiome studies. For example, we may collect pre- and post-treatment samples from a set of individuals, or use important confounding variables to match data from case participants ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40168-021-01034-9

Sequential Portal Vein Embolization and Percutaneous Radiofrequency Ablation for Future Liver Remnant Growth: A Minimally Invasive Alternative to ALPPS Stage-1 in Treatment of Hepatocellular Carcinoma

Qiang Wang, Qiang Wang, Yujun Ji, Torkel B. Brismar et al. • Frontiers in Surgery (2021)

Background: To evaluate the feasibility and efficacy of sequential portal vein embolization (PVE) and radiofrequency ablation (RFA) (PVE+RFA) as a minimally invasive variant for associating liver partition and portal vein ligation for stage...

DOAJ Open Access (DOAJ) DOI: 10.3389/fsurg.2021.741352

Cerebrospinal fluid-stem cell interactions may pave the path for cell-based therapy in neurological diseases

Chao Ren, Peiyuan Yin, Neng Ren, Zhe Wang et al. • Stem Cell Research & Therapy (2018)

Abstract Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and other neurological disea...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13287-018-0807-3

Molecular docking and mouse modeling suggest CMKLR1 and INSR as targets for improving PCOS phenotypes by minocycline

Mahdie Kian, Elham Hosseini, Tooba Abdizadeh, Taimour Langaee et al. • EXCLI Journal : Experimental and Clinical Sciences (2022)

Polycystic ovary syndrome (PCOS) is the most common cause of women’s infertility. Some inflammatory pathways play a pivotal role in the pathogenesis of PCOS. This study aimed to investigate the possible beneficial effects of minocycline on ...

DOAJ Open Access (DOAJ) DOI: 10.17179/excli2021-4534

Functional Assessment of the Quality of Human Hepatocyte Preparations for Cell Transplantation

María Teresa Donato, Agustín Lahoz, Sandra Montero, Ana Bonora et al. • Cell Transplantation (2008)

Hepatocyte transplantation is an alternative therapy to orthotopic liver transplantation for the treatment of liver diseases. Good quality freshly isolated or cryopreserved human hepatocytes are needed for clinical transplantation. However,...

DOAJ Open Access (DOAJ) DOI: 10.3727/096368908787236620

Grain boundary and texture evolution of TiB/Ti–2Al–6Sn titanium matrix composite under electroshocking treatment

Yaya Wu, Yan Wen, Anan Guo, Jian Zhou et al. • Journal of Materials Research and Technology (2023)

This work used electroshocking treatment (EST) plus external loading to regulate the microstructure of titanium matrix composites (TMCs). The external loading was 0.3 MPa. After EST plus external loading with 0.3 MPa, the α was reduced to 2...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jmrt.2023.10.177

3D Printing parameter optimisation combined with heat treatment for achieving high density and enhanced performance in refractory high-entropy alloys

Deyu Jiang, Miao Luo, Changxi Liu, Yashuo Zhang et al. • Virtual and Physical Prototyping (2025)

In this study, a Ti1.5Nb1Ta0.5Zr1Mo0.5 (TNTZM) high-entropy alloy was fabricated using laser powder bed fusion (LPBF). By integrating 63 sets of parameter trials with machine learning (ML) models, an optimised process window was identified,...

DOAJ Open Access (DOAJ) DOI: 10.1080/17452759.2025.2524524

A Preliminary Study on the Efficacy of Essential Oils Against <i>Trichoderma longibrachiatum</i> Isolated from an Archival Document in Italy

Benedetta Paolino, Maria Cristina Sorrentino, Severina Pacifico, Maria Carmen Garrigos et al. • Heritage (2025)

In this study, a historically significant journal subject to fungal colonization was used as a case study for experimenting with a fumigation treatment using essential oils. The experiments were carried out both in vitro and in vivo directl...

DOAJ Open Access (DOAJ) DOI: 10.3390/heritage8060187

Sensitivity Analysis and Uncertainty Quantification of Nanoparticle Deposition from Tongue Morphological Variations

Tiancheng Yang, Xiuhua Si, Jinxiang Xi • Life (2024)

The human tongue has highly variable morphology. Its role in regulating respiratory flows and deposition of inhaled aerosols remains unclear. The objective of this study was to quantify the uncertainty of nanoparticle deposition from the va...

DOAJ Open Access (DOAJ) DOI: 10.3390/life14030406

Evaluating key predictors of breast cancer through survival: a comparison of AFT frailty models with LASSO, ridge, and elastic net regularization

Senyefia Bosson-Amedenu, Emmanuel Ayitey, Francis Ayiah-Mensah, Luyton Asare • BMC Cancer (2025)

Abstract Background Frailty models are extensively utilized in survival analysis to address unobserved heterogeneity among individuals. However, selecting the most robust model for survival prediction, especially in the context of high-dime...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12885-025-14040-z

Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types

Sipeng Shen, Ruyang Zhang, Yue Jiang, Yi Li et al. • Molecular Cancer (2021)

Abstract N6-Methyladenosine (m6A) is an RNA modification that interacts with numerous coding and non-coding RNAs and plays important roles in the development of cancers. Nonetheless, the clinical impacts of m6A interactive genes on these ca...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12943-021-01362-2

Modelling the adsorption of iron and manganese by activated carbon from teak and shea charcoal for continuous low flow

Worlanyo Kwadjo Siabi, Emmanuel Degraft-Johnson Owusu-Ansah, Helen Michelle Korkor Essandoh, Nana Yaw Asiedu • Water-Energy Nexus (2021)

Nearly 6494 boreholes with iron (Fe) and manganese (Mn) concentrations above permissible limits of 0.3 mg/L and 0.4 mg/L respectively in Ghana have been abandoned because of ineffective water treatment solutions. Activated carbon prepared f...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.wen.2021.02.001

Modeling antiretroviral therapy adherence among people living with HIV: a cross-sectional study at Pantang Hospital, Ghana

Eric Nyarko, Irene A. Kretchy, Grace Lovia Allotey-Babington, Adwoa Oforiwaa Kwakye et al. • BMC Infectious Diseases (2026)

Abstract Background Poor adherence to antiretroviral therapy (ART) continues to undermine HIV treatment outcomes in sub-Saharan Africa, including Ghana. Objective This study aimed to quantify ART treatment adherence among people living with...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12879-026-13836-z

Ranking of treatments in network meta-analysis: incorporating minimally important differences

Tristan Curteis, Augustine Wigle, Christopher J. Michaels, Adriani Nikolakopoulou • BMC Medical Research Methodology (2025)

Abstract Background In network meta-analysis (NMA), the magnitude of difference between treatment effects is typically ignored in the calculation of ranking metrics, such as probability best and surface under the cumulative ranking curve (S...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12874-025-02499-0

Mathematical Modeling of Leptospirosis With Misdiagnosis

Japheth Musingila Mwongela, Caroline Kanyiri, Virginia Kitetu • Journal of Applied Mathematics (2026)

Leptospirosis is a widespread zoonotic bacterial disease that continues to pose a major public health challenge, particularly in developing countries where it causes substantial morbidity, mortality, and economic losses. A key problem in co...

DOAJ Open Access (DOAJ) DOI: 10.1155/jama/5513951

Ecological, Biological and Control Studies on the Leaf Coating and Webbing Mite Cisaberoptus kenyae Keifer (Eriophyoidea: Eriophyidae) in Egypt

B. Abou-Awad, A. Metwally, M. Al&ndash;Azzazy • Acarines: Journal of the Egyptian Society of Acarology (2009)

The leaf coating and webbing mite Cisaberoptus kenyae Keifer was observed for two years in an abandoned mangoorchard in Egypt. The eriophyid mite was fed upon by the two predatory phytoseiid mites Typhlodromips swirskii(Athias-Henriot) and ...

DOAJ Open Access (DOAJ) DOI: 10.21608/ajesa.2009.4968