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Academic Articles & Research Papers
Showing 20 of 9,867 academic articles
Qinghua Luo, Xintan Dong, Zhaxi Zerang, Yujiao Chen et al. • Cell Reports
(2026)
Summary: The β-barrel assembly machinery (BAM) is essential for outer membrane protein (OMP) biogenesis in Gram-negative bacteria and represents a validated target for antibiotic development. Its evolutionary relative, the translocation and...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.celrep.2026.117733
Martin Sindelar, Anna Kocurkova, Matej Simek, Pavel Roudnicky et al. • MicrobiologyOpen
(2026)
ABSTRACT The ability of gut microbes to degrade host‐ and diet‐derived glycans is central to microbiome ecology and host interactions, yet predicting these functions in silico remains challenging. Hyaluronan (HA), a glycosaminoglycan (GAG) ...
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Open Access (DOAJ)
DOI: 10.1002/mbo3.70227
Adam H. Tencer, Jiuyang Liu, Jing Zhu, Nathaniel T. Burkholder et al. • Scientific Reports
(2022)
Abstract The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein. Here, we show that the ZZ domain of HERC2 (HERC2ZZ) recognizes a mimetic of the Nt-R cargo ...
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Open Access (DOAJ)
DOI: 10.1038/s41598-022-10119-w
Hoda Zarkoob, Anna Allué-Guardia, Yu-Chi Chen, Andreu Garcia-Vilanova et al. • Communications Biology
(2022)
Human alveolar and tracheobronchial epithelial air liquid interface (ALI) tissues are used as models to examine cellular responses to SARS-CoV-2 and influenza A virus infections and as antiviral drug screening assay platforms....
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Open Access (DOAJ)
DOI: 10.1038/s42003-022-03753-7
Veronika Heinz, Wenke Jäckel, Susann Kaltwasser, Laura Cutugno et al. • Communications Biology
(2022)
A cryo-electron microscopy reconstruction of a stressosome complex from a Gram-negative bacterium, Vibrio vulnificus, reveals variations in subunit composition and symmetry, which could serve to adjust the activation threshold in the respon...
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Open Access (DOAJ)
DOI: 10.1038/s42003-022-03548-w
Khushboo Singh, Roon Banerjee, Chandrakanta Potdar, Anisha Shaw et al. • Cells
(2026)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson’s disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 di...
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Open Access (DOAJ)
DOI: 10.3390/cells15040342
Victoria Vitkova, Vesela Yordanova, Galya Staneva, Ognyan Petkov et al. • Membranes
(2021)
Simple carbohydrates are associated with the enhanced risk of cardiovascular disease and adverse changes in lipoproteins in the organism. Conversely, sugars are known to exert a stabilizing effect on biological membranes, and this effect is...
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Open Access (DOAJ)
DOI: 10.3390/membranes11110847
Augusto Berrocal, Nicholas C Lammers, Hernan G Garcia, Michael B Eisen • eLife
(2020)
We used live imaging to visualize the transcriptional dynamics of the Drosophila melanogaster even-skipped gene at single-cell and high-temporal resolution as its seven stripe expression pattern forms, and developed tools to characterize an...
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Open Access (DOAJ)
DOI: 10.7554/eLife.61635
Yashar Bashirzadeh, Hossein Moghimianavval, Allen P. Liu • iScience
(2022)
Summary: Cell shape changes from locomotion to cytokinesis are, to a large extent, driven by myosin-driven remodeling of cortical actin patterns. Passive crosslinkers such as α-actinin and fascin as well as actin nucleator Arp2/3 complex la...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.isci.2022.104236
Stefania Martucciello, Marchesa Bilio, Sara Cioffi, Ilaria Aurigemma et al. • Journal of Cardiovascular Development and Disease
(2026)
Gene inactivation in model organisms has identified numerous genes and signaling pathways involved in mammalian cardiac outflow tract (OFT) development. Human genetics data have implicated the VEGFR3 gene in OFT development, but when and wh...
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Open Access (DOAJ)
DOI: 10.3390/jcdd13080399
Ligia Soares Lima, Jessyca Sousa de Brito, Marcelo Ribeiro-Alves, Karen Salve Coutinho-Wolino et al. • Foods
(2025)
Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...
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Open Access (DOAJ)
DOI: 10.3390/foods14234030
Eleanor Feneck, Malcolm Logan • Biomolecules
(2020)
Retinoic acid (RA) was one of the first molecules in the modern era of experimental embryology to be shown capable of generating profound effects on limb development. In this review, we focus on the earliest events of limb development and s...
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Open Access (DOAJ)
DOI: 10.3390/biom10020312
Saul Vislei Simões da Silva, Orlando Maia Barboza, Jéssica Teles Souza, Érica Novaes Soares et al. • Molecules
(2021)
Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological use. The aim of this study was to perform structural mod...
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Open Access (DOAJ)
DOI: 10.3390/molecules26226923
Natsuko Kitajima, Takahisa Nakajo, Takeshi Katayoshi, Kentaro Tsuji-Naito • Biochemistry and Biophysics Reports
(2023)
Sebocytes express Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), which participate in the innate immune response of the skin. Although the roles of TLRs and NLR family pyrin domain-cont...
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Open Access (DOAJ)
DOI: 10.1016/j.bbrep.2023.101561
Maria Angelova, Petko Alov, Ivanka Tsakovska, Dessislava Jereva et al. • Molecules
(2025)
Scoring functions are key elements in docking protocols as they approximate the binding affinity of a ligand (usually a small bioactive molecule) by calculating its interaction energy with a biomacromolecule (usually a protein). In this stu...
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Open Access (DOAJ)
DOI: 10.3390/molecules30132777
Li Rong, Haiyu Li, Zhaodong Li, Jing Ouyang et al. • Frontiers in Medicine
(2020)
Background and Objective: Chemotherapy and radiotherapy are effective treatment options for cervical cancer (CC), but their efficacy is limited by short survival rate of about 5 years particularly for advance stage CC. Bioinformatics analys...
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Open Access (DOAJ)
DOI: 10.3389/fmed.2020.608441
Qian Qin, Zhiyan Shan, Lei Xing, Yutong Jiang et al. • Journal of Translational Medicine
(2024)
Abstract Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental disorder predominant in childhood. Despite existing treatments, the benefits are still limited. This study explored the effectiveness of mesenchymal stem cell-deri...
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Open Access (DOAJ)
DOI: 10.1186/s12967-024-05257-w
Balamurugan Jagadeesan, Leen Baert, Martin Wiedmann, Renato H. Orsi • Frontiers in Microbiology
(2019)
As WGS is increasingly used by food industry to characterize pathogen isolates, users are challenged by the variety of analysis approaches available, ranging from methods that require extensive bioinformatics expertise to commercial softwar...
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Open Access (DOAJ)
DOI: 10.3389/fmicb.2019.00947
Irandi Putra Pratomo, Dimas R. Noor, Kusmardi Kusmardi, Andriansjah Rukmana et al. • International Journal of Inflammation
(2021)
Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a ...
DOAJ
Open Access (DOAJ)
DOI: 10.1155/2021/1653392
Xhulio Dhori, Silvia Gioiosa, Stefania Gonfloni • Scientific Data
(2024)
Abstract Granulosa cells (GCs) play crucial roles in oocyte maturation. Through gap junctions and extracellular vesicles, they mediate the exchange of molecules such as microRNAs and messenger RNAs. Different ovarian cell types exhibit uniq...
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Open Access (DOAJ)
DOI: 10.1038/s41597-024-03715-0