Academic Articles & Research Papers

EPEPT: A web service for enhanced P-value estimation in permutation tests

Abstract Background In computational biology, permutation tests have become a widely used tool to assess the statistical significance of an event under investigation. However, the common way of computing the P-value, which expresses the sta...

Statistical data for the tensile properties and static fatigue of sic-based bundles

Due to their high specific strength at elevated temperatures and resistance to oxidative environments, SiC-based fibers are of great interest for the reinforcement of ceramic matrix composites. They are however subjected to a slow crack gro...

Automated measurement of CD8+ T-cell distribution at the tumor epithelial–stromal interface is associated with NSCLC immunotherapy benefit and transcriptomic pathways

Whereas anti-PD-(L)1 therapies are widely used in cancer treatment, only a subset of patients achieve long-term survival. Companion diagnostics based on PD-L1 expression have limited predictive power for these therapies, motivating developm...

Real-World Evaluation of AI-Driven Diabetic Retinopathy Screening in Public Health Settings: Validation and Implementation Study

Abstract BackgroundArtificial intelligence (AI) algorithms offer an effective solution to alleviate the burden of diabetic retinopathy (DR) screening in public health settings. However, there are challenges in translating diagno...

Mapping Intellectual Structure of Health Literacy Area Based on Co-Word Analysis in Web of Science Database during the Years 1993-2017

Introduction: Creating an image of the conceptual structure of health literacy area, as well as the study of interdisciplinary and the relationship between its domains seems necessary. The present study examined the intellectual structure o...

G-Aligner: a graph-based feature alignment method for untargeted LC–MS-based metabolomics

Abstract Background Liquid chromatography–mass spectrometry is widely used in untargeted metabolomics for composition profiling. In multi-run analysis scenarios, features of each run are aligned into consensus features by feature alignment ...

Challenges and conditions for successfully implementing and adopting the telematics infrastructure in German outpatient healthcare: A qualitative study applying the NASSS framework

Background Germany's healthcare system provides high-quality, universal health coverage to almost all residents. However, a major challenge lies in the strong separation of healthcare structures, which hinders efficient interprofessional an...

Injury death certificates without specification of the circumstances leading to the fatal injury – the Norwegian Cause of Death Registry 2005–2014

Abstract Background For injury deaths, the underlying cause of death is defined as the circumstances leading to the injury. When this information is missing, the ICD-10 code X59 (Exposure to unspecified factor) is used. Lack of knowledge of...

Comparison of the effectiveness of an oral combination of thiamine, pyridoxine, and cyanocobalamin with parenteral cyanocobalamin in adolescents with nutritional vitamin B12 deficiency

Aims: Nutritional vitamin B12 deficiency remains a significant public health issue. This study aimed to compare the efficacy of an oral combination of thiamine, pyridoxine, cyanocobalamin, and parenteral cyanocobalamin treatment among adole...

Medical informatics in the new millennium.

In a period of social transformation, we must reinvent health care. For guidance, we can look to the evolving discipline of medical informatics and to the patterns of investment in the practice arena. A top ranked application need, the comp...

Evolution of Trends in European Medical Informatics

This presentation attempts to analyze the trends in Medical Informatics along half a century, in the European socio-political and technological development context. Based on the major characteristics which seem dominant in some periods, a s...

Milestones in Romanian medical informatics.

The paper concerns the major activities in the field of medical informatics in Romania: education, computer technology, implementation in healthcare, role of industry, IT use in medical applications and research....

Software Engineering Education in Medical Informatics

Requirements and approaches of Software Engineering education in the field of Medical Informatics are described with respect to the impact of (1) experiences characterizing the "software misery", (2) status and tendencies in software method...

Measuring agreement in medical informatics reliability studies

Medical Informatics and Bioinformatics: European Efforts to Facilitate Synergy

Medical Informatics, Biometry and Epidemiology

Correspondence to: Prof. Dr. rer. nat. habil. Heinz Handels Institute of Medical Informatics University of Lubeck Ratzeburger Allee 16...

Medical Informatics

Modeling a medical environment: an ontology for integrated medical informatics design

Medical informatics across Europe: Analysis of medical informatics scientific output in 33 European countries

OBJECTIVES: To investigate the medical informatics scientific output in 33 European countries. METHODS: Medical Subject Heading term "medical informatics" was used to identify all relevant articles published in 1998-2007 and indexed in the ...

Quantum computing in medical informatics

In an era of exponential technological advancements, the integration of quantum computing (QC) and medical informatics emerges as a captivating frontier, promising to unlock a new realm of possibilities for healthcare. QC, harnessing the pr...