Academic Articles & Research Papers

MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis

Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity. Mycobacterial membrane protein large (MmpL) proteins export bulky...

Global variations in funding and use of hemodialysis accesses: an international report using the ISN Global Kidney Health Atlas

Abstract Background There is a lack of contemporary data describing global variations in vascular access for hemodialysis (HD). We used the third iteration of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) to ...

Worldwide productivity and research trend of publications concerning extracellular vesicles role in fibrosis: A bibliometric study from 2013 to 2022

Background: Fibrosis is a heavy burden on the global healthcare system. Recently, an increasing number of studies have demonstrated that Extracellular vesicles play an important role in intercellular communication under both physiological a...

Characterization of Primate Antibody Responses to Administered Murine Monoclonal Immunoglobulin

Murine monoclonal antibodies (MAb) are currently being assessed for their utility as tools in cancer management. Anti-murine immunoglobulin responses have been observed in many patients receiving monoclonal antibody treatment. In this study...

Saccharomyces boulardii RC009 as an alternative to prophylactic antibiotics: effects on broiler chickens, performance, and gut microbiome

This study evaluates the effects of supplementing broiler chicken feed with the probiotic Saccharomyces cerevisiae var. boulardii RC009 as a sustainable alternative to prophylactic antibiotics. The focus was on productive performance, gut m...

Natural Cytotoxicity Receptors: Pattern Recognition and Involvement of Carbohydrates

Natural cytotoxicity receptors (NCRs), expressed by natural killer (NK) cells, trigger NK lysis of tumor and virus-infected cells on interaction with cell-surface ligands of these target cells. We have determined that viral hemagglutinins e...

Ovarian cancer treatment and natural killer cell-based immunotherapy

BackgroundOvarian cancer (OC) is one of the malignant tumors that poses a serious threat to women’s health. Natural killer (NK) cells are an integral part of the immune system and have the ability to kill tumor cells directly or participate...

Serum Bilirubin Level Changes in Multiple Sclerosis Patients

Background: Multiple Sclerosis (MS) is a demyelinating disorder of the Central Nervous System (CNS). In addition to the role of immune mediated mechanisms, oxidative and nitrosative stress also play an important role in neuropathology of MS...

Shotgun metagenomic sequencing of serum extracellular vesicle-derived DNA enables microbial profiling in urothelial carcinoma

Abstract Shotgun metagenomic sequencing provides more detailed microbial information than 16 S rRNA sequencing but requires higher cost and larger sample volumes. We evaluated whether shotgun metagenomic sequencing could detect bacterial DN...

Fundamental Immunology

“Immunology is the quintessential medical science. Indeed, no branch of the medical sciences has improved the health of people more than the application of immunologic principles to prevention of disease” (p xiii). So begins the sixth editi...

Long-term exposure to air pollution and incidence risk of various arrhythmias: A prospective cohort study

To investigate the association of long-term exposure to air pollution with incident arrhythmia from various causes, this prospective cohort study included 442,386 participants from the UK Biobank cohort. Residential annual average exposures...

Improving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial

ABSTRACT Background Treatments aimed at improving physical function and body composition, including reducing fat mass (FM) and increasing muscle mass, may benefit individuals with advanced knee osteoarthritis (OA) and obesity. We investigat...

Uncertainties in the effects of organic aerosol coatings on polycyclic aromatic hydrocarbon concentrations and their estimated health effects

We used the CAM5 model to examine how different particle-bound polycyclic aromatic hydrocarbon (PAH) degradation approaches affect the spatial distribution of benzo(a)pyrene (BaP). Three approaches were evaluated: NOA (no effect of OA coati...

Work as the missing link in Europe's Climate and Health Strategic Research Agenda.

Nano-enabled microbial bioinputs for sustainable agriculture: advances, mechanisms, applications, and future challenges

Microbial bioinputs have emerged as key components of sustainable agriculture owing to their ability to promote plant growth, improve nutrient acquisition, enhance tolerance to biotic and abiotic stresses, and suppress phytopathogens. Despi...

Network Analysis of Medical Claims Data Suggests Network-Based, Regional Targeting and Intervention Delivery Strategies to Increase Access to Office Based Opioid Treatment (OBOT) for Opioid Use Disorder (OUD)

Opioid overdose and Opioid Use Disorder (OUD) statistics underscore an urgent need to significantly expand access to evidence-based OUD treatment. Office Based Opioid Treatment (OBOT) has proven effective for treating OUD. However, limited ...

Seroprevalence of dengue, yellow fever, and related flaviviruses among the rural human population in Nguruman and Kerio Valley, Kenya

BackgroundYellow fever virus (YFV) and dengue virus (DENV) are among the major re-emerging arboviruses that pose a significant threat to public health. Their associated burden and prevalence can be substantially underestimated due to insuff...

Transient Elastography and Video Recovery Narrative Access to Support Recovery From Alcohol Misuse: Development of a Novel Intervention for Use in Community Alcohol Treatment Services

BackgroundMortality from alcohol-related liver disease has risen significantly for 3 decades. Transient elastography (TE) is a noninvasive test providing a numerical marker of liver disease. Preliminary evidence suggests that TE can reduce ...

Ensino de saneamento do meio nas escolas de saúde pública Teaching environmental sanitation in schools of public health

Após a última guerra mundial, e especialmente nesta década, em decorrência do crescimento demográfico e do desenvolvimento industrial, a par de migração da população rural em direção aos conglomerados urbanos, aumentaram os problemas relaci...

Modelling the trends of the healthcare funding in the EU countries

Healthcare is one of the most important sectors of the public economy in the EU countries. An important task in the analysis and prediction of the values for healthcare funding is the development and application of quantitative models based...