Academic Articles & Research Papers

SequelTools: a suite of tools for working with PacBio Sequel raw sequence data

Abstract Background PacBio sequencing is an incredibly valuable third-generation DNA sequencing method due to very long read lengths, ability to detect methylated bases, and its real-time sequencing methodology. Yet, hitherto no tool was av...

‘Optimal’ cutoff selection in studies of depression screening tool accuracy using the PHQ‐9, EPDS, or HADS‐D: A meta‐research study

Abstract Objectives Optimal cutoff thresholds are selected to separate ‘positive’ from ‘negative’ screening results. We evaluated how depression screening tool studies select optimal cutoffs. Methods We included studies from previously cond...

Wrist movements induce torque and lever force in the scaphoid: an ex vivo study

Abstract Purpose We hypothesised that intercarpal K-wire fixation of adjacent carpal bones would reduce torque and lever force within a fractured scaphoid bone. Methods In eight cadaver wrists, a scaphoid osteotomy was stabilised using a lo...

Injury death certificates without specification of the circumstances leading to the fatal injury – the Norwegian Cause of Death Registry 2005–2014

Abstract Background For injury deaths, the underlying cause of death is defined as the circumstances leading to the injury. When this information is missing, the ICD-10 code X59 (Exposure to unspecified factor) is used. Lack of knowledge of...

Comparison of the effectiveness of an oral combination of thiamine, pyridoxine, and cyanocobalamin with parenteral cyanocobalamin in adolescents with nutritional vitamin B12 deficiency

Aims: Nutritional vitamin B12 deficiency remains a significant public health issue. This study aimed to compare the efficacy of an oral combination of thiamine, pyridoxine, cyanocobalamin, and parenteral cyanocobalamin treatment among adole...

Performance of computational algorithms to deconvolve heterogeneous bulk ovarian tumor tissue depends on experimental factors

Abstract Background Single-cell gene expression profiling provides unique opportunities to understand tumor heterogeneity and the tumor microenvironment. Because of cost and feasibility, profiling bulk tumors remains the primary population-...

Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt

Abstract Background Many cancers arise from mutations in cells within epithelial tissues. Mutations manifesting at the subcellular level influence the structure and function of the tissue resulting in cancer. Previous work has proposed how ...

Association of androgen receptor and tumour-infiltrating lymphocytes with bone recurrence in triple-negative breast cancer

Background: As compared to endocrine responsive breast cancer bone is less frequent site of distant recurrence in triple-negative breast cancer (TNBC). A biomarker which predicts bone recurrence would allow a more personalized treatment app...

Informatics, Medical Informatics, Statistics

Behind the scars: adolescents with non-suicidal self-injury disorder show profound personality pathology

Abstract Background Non-suicidal self-injury is a significant clinical concern in adolescent psychiatry and frequently co-occurs with a range of psychiatric disorders, including mood disorders, eating disorders, substance use disorders, and...

Early Retinal Microvascular Alterations in Young Type 1 Diabetic Patients without Clinical Retinopathy

The purpose of this study is to identify and quantify preclinical changes with the help of optical coherence tomography angiography (OCTA) within the retinal microcirculation of young type 1 diabetes (T1D) patients without clinical signs of...

Impact of medical informatics on medical education.

In recent years, medical informatics has become a well-recognized branch of medicine. It is a multidisciplinary science that combines information technology and various specialties of medicine. The impact of medical informatics on medical e...

Data on gender-equitable healthcare accessibility in Northern Nigeria

Gender equity, particularly in healthcare, has been gaining increasing attention in recent years. The goal is to ensure that everyone has equal access to quality healthcare services irrespective of age, gender, or socio-economic status. How...

Dataset on perception of public college students on underage drinking in Nigeria

Alcohol is the most widely used substance of abuse among youths in Nigeria. Underage drinking poses a serious public health problem in most colleges and despite the health and safety risk, consumption of alcohol is rising. Having recourse t...

Estimation of the probability of daily fluctuations of incidence of COVID-19 according to official data

When studying the dynamics of morbidity and mortality, one should not limit ourselves to analyzing general trends. Interesting information can be obtained from the analysis of deviations in morbidity and mortality from the general dynamics....

Income and education predict elevated depressive symptoms in the general population: results from the Gutenberg health study

Abstract Background Socioeconomic status (SES) has a strong association with depression or physical and mental health in general. However, as SES is a multifaceted construct these associations are not easy to explain. Further, there are sev...

Denosumab and Bisphosphonate Treatment of Osteoporosis in Renal Transplant Recipients

Objective: Kidney transplant recipients are at risk of losing bone mineral density. Osteoporosis and fractures cause serious complications in renal transplant recipients. We aimed to evaluate the efficacy and safety of bisphosphonate and de...

Percutaneous CT-Guided Bone Lesion Biopsy for Confirmation of Bone Metastases in Patients with Breast Cancer

We aimed to determine diagnostic accuracy of CT-guided bone lesion biopsy for the confirmation of bone metastases in patients with breast cancer and assessment of hormone receptor status in metastatic tissue. A total of 56 female patients w...

Secondary research use of personal medical data: patient attitudes towards data donation

Abstract Background The SARS-CoV-2 pandemic has highlighted once more the great need for comprehensive access to, and uncomplicated use of, pre-existing patient data for medical research. Enabling secondary research-use of patient-data is a...

Medical informatics--an interdisciplinary approach.

Medical informatics is the first science that has incorporated all traditional medical disciplines. That progress is possible due to fast development of new technologies, particularly in informatics, as well as due to common needs of all me...