Academic Articles & Research Papers

Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using <i>Lactiplantibacillus plantarum</i> TY-Y10

Oxidative stress is closely linked to aging. Probiotics, whether viable or heat-inactivated, have shown antioxidant properties; however, their effect and mechanism of action in reducing oxidative stress during aging remains underexplored. T...

Barriers and facilitators of retention in care after cervical cancer screening: patients’ and healthcare providers’ perspectives

Abstract Background Cervical cancer continues to threaten women’s health, especially in low-resource settings. Regular follow-up after screening and treatment is an effective strategy for monitoring treatment outcomes. Consequently, underst...

Analysis of TORCH screening and prenatal risk assessment for childbearing-age women in different regions of China

Abstract Objective By conducting TORCH screening and risk assessment analysis on childbearing-age women in different regions of China, the aim is to provide reference for reducing adverse pregnancy outcomes and improving the health status o...

Predictive Value of Serum Cytokeratin 19 Level for the Feasibility of Conserving Ovaries in Endometrial Cancer

Objective: To determine the predictive value of cytokeratin 19 (CK19) for evaluating the safety of ovarian preservation in patients with endometrial cancer (EC).Methods: Five hundred and seventeen EC patients hospitalized from November 2010...

Further validation of the Chinese short Warwick Edinburgh mental wellbeing scale in the adult population of Macau: an application of classic test theory and item response theory

BackgroundThis study aims to validate the Chinese version of the Short Warwick-Edinburgh Mental Well-being Scale (SWEMWBS) by employing both Classical Test Theory (CTT) and Item Response Theory (IRT) approaches.MethodsData were gathered thr...

European Law and New Health Technologies

Health is a matter of fundamental importance in European societies, both as a human right in itself, and as a factor in a productive workforce and therefore a healthy economy. New health technologies promise improved quality of life for pat...

Ethical analysis to improve decision-making on health technologies

Health technology assessment (HTA) is the multidisciplinary study of the implications of the development, diffusion and use of health technologies. It supports health-policy decisions by providing a joint knowledge base for decision-makers....

HEALTH TECHNOLOGY ASSESSMENT IN EUROPE

This paper discusses the challenges facing health technology assessment (HTA) in Europe, based on an explicit analysis of the characteristics of an "optimal" HTA system. It has three objectives: a) to elaborate an explicit system of policy ...

LADS: a powerful vaccine platform for cancer immunotherapy and prevention

Abstract Background The intracellular bacterium Listeria monocytogenes is an attractive vector for cancer immunotherapy as it can effectively deliver tumor antigens to antigen-presenting cells, leading to a robust antitumor response. Result...

Computable phenotype for real-world, data-driven retrospective identification of relapse in ANCA-associated vasculitis

Objective ANCA-associated vasculitis (AAV) is a relapsing-remitting disease, resulting in incremental tissue injury. The gold-standard relapse definition (Birmingham Vasculitis Activity Score, BVAS&gt;0) is often missing or inaccurate in re...

Design and Optimization of Trastuzumab-Functionalized Nanolipid Carriers for Targeted Capecitabine Delivery: Anti-Cancer Effectiveness Evaluation in MCF-7 and SKBR3 Cells

Shubhashree Das,1 Bhabani Sankar Satapathy,2 Gurudutta Pattnaik,1 Sovan Pattanaik,3 Yahya Alhamhoom,4 Mohamed Rahamathulla,4 Mohammed Muqtader Ahmed,5 Ismail Pasha6 1Department of Pharmaceutics, School of Pharmacy and Life Sciences, Centuri...

Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Abstract Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not ...

Preferences for and drivers of adult vaccination clinic site selection: A cross-sectional study in 30 provinces in China

Focusing on vaccines available to adults and not in the immunization schedule, this study investigates the preferences and factors influencing adults in selecting vaccination clinic locations. It aims to provide strategic insights for boost...

Influence of Different Disinfectants on Surface Hardness of Heat-Polymerized Acrylic Resins utilized for Orthodontic Appliance

Heat-polymerized resins are common substances utilized for construction of removable dental prostheses (i.e. Orthodontic appliances). Such materials should have appropriate physical properties. The use of disinfectant solutions might influe...

Operating pesticide use reduction within the boundary of food security in peri-urban settings

Pesticide use in peri-urban areas affects the urban environment and public health, and reducing the use may present food security issues for urban dwellers. In this study, we explore how a municipality-adopted goal of a 20% reduction in pes...

Compounds of Marine Origin with Possible Applications as Healing Agents

It is well established that marine organisms consist of a great variety of active compounds that appear exclusively in the marine environment while having the ability to be vastly reproduced, irrespective of the existing conditions. As a re...

Global Challenges of Health Technology

The Role of Health Technology and Informatics in a Global Public Health Emergency: Practices and Implications From the COVID-19 Pandemic

At present, the coronavirus disease (COVID-19) is spreading around the world. It is a critical and important task to take thorough efforts to prevent and control the pandemic. Compared with severe acute respiratory syndrome and Middle East ...

Health technology and primary health care

HEALTH TECHNOLOGY

Essential health care requires essential health technology, a technology which people can understand and which the non-expert can apply. The identification or generation of such technology forms part of the revolution in community health an...