Academic Articles & Research Papers

Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli

Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) has been implicated in a range of conditions and pathologies from prostate to hepatic cancer. Here, we describe the expression in Escherichia coli and the purification protocol for the f...

Online peer support for Young Onset Dementia is a promising resource, but not a panacea: a commentary from the INTERDEM Young Onset Dementia taskforce

SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature

Abstract Background Single Nucleotide Polymorphisms (SNPs) are among the most important types of genetic variations influencing common diseases and phenotypes. Recently, some corpora and methods have been developed with the purpose of extra...

Medical Informatics in Iran and the Emergence of Clinical Informatics.

Medical Informatics, an emerging multidisciplinary field at the intersection of medicine, technology, and information sciences, is believed to significantly impact health and medical practice....

Health and Medical Informatics Education

Health and medical informatics education has meanwhile gained considerable importance for medicine and for health care. Specialized programs in health/medical informatics have therefore been established within the last decades. This special...

Are Medical Informatics and Nursing Informatics Distinct Disciplines?: The 1999 ACMI Debate

The 1999 debate of the American College of Medical Informatics focused on the proposition that medical informatics and nursing informatics are distinctive disciplines that require their own core curricula, training programs, and professiona...

Medical Informatics, Artefacts or Science?

Successful and productive medical informatics research is evidently a combination of luck, creative art, and science, but some researchers focus too much on building computer artefacts and writing anecdotal reports of their experience. They...

Workshop on medical informatics and engineering

MI&E 2009 will bring researchers, developers, practitoners, and users to present their latest research, results, and ideas in all areas of medical informatics, engineering and artificial intelligence in medicine and health care....

Actual problems in medical informatics.

Medical informatics has been the first science that connects all traditional medical disciplines, thanking to common information needs and requirements of these disciplines. Its goal is incorporating of information technology into medical p...

Deep learning-based multimodal data fusion in bone tumor management: Advances in clinical decision support

Bone tumors (BTs)—including osteosarcoma, Ewing sarcoma, and chondrosarcoma—are rare but biologically complex malignancies characterized by pronounced heterogeneity in anatomical location, histological subtype, and molecular alterations. Re...

Examining the characteristic features of lipedema and the usefulness of BMI and WHtR in clinical evaluation

Abstract Background Lipedema is an adipose tissue disorder involving mostly women. One of the most characteristic lipedema symptoms is painful accumulation of adipose tissue in lower and upper extremities leading to disproportion. Due to th...

Medical and Health-Related Misinformation on Social Media: Bibliometric Study of the Scientific Literature

BackgroundSocial media has been extensively used for the communication of health-related information and consecutively for the potential spread of medical misinformation. Conventional systematic reviews have been published on this topic to ...

The thalamus and its subregions – a gateway to obsessive-compulsive disorder

Introduction Higher thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population (Boedhoe et al. 2017, Weeland et al. 2021a). Functionally distin...

Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity

Abstract Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the $$S/F$...

Cytogenetics data in adult men involved in the recycling of electronic wastes

In this data article, 146 villagers (exposed group) were randomly selected from the workers who involved in the e-wastes recycling directly as a daily job in Tianjin. Control group, including 121 villagers, came from another town without e-...

‘Optimal’ cutoff selection in studies of depression screening tool accuracy using the PHQ‐9, EPDS, or HADS‐D: A meta‐research study

Abstract Objectives Optimal cutoff thresholds are selected to separate ‘positive’ from ‘negative’ screening results. We evaluated how depression screening tool studies select optimal cutoffs. Methods We included studies from previously cond...

Fast Healthcare Interoperability Resources (FHIR) for Interoperability in Health Research: Systematic Review

BackgroundThe standard Fast Healthcare Interoperability Resources (FHIR) is widely used in health information technology. However, its use as a standard for health research is still less prevalent. To use existing data sources more efficien...

Automated measurement of CD8+ T-cell distribution at the tumor epithelial–stromal interface is associated with NSCLC immunotherapy benefit and transcriptomic pathways

Whereas anti-PD-(L)1 therapies are widely used in cancer treatment, only a subset of patients achieve long-term survival. Companion diagnostics based on PD-L1 expression have limited predictive power for these therapies, motivating developm...

Mapping Intellectual Structure of Health Literacy Area Based on Co-Word Analysis in Web of Science Database during the Years 1993-2017

Introduction: Creating an image of the conceptual structure of health literacy area, as well as the study of interdisciplinary and the relationship between its domains seems necessary. The present study examined the intellectual structure o...

G-Aligner: a graph-based feature alignment method for untargeted LC–MS-based metabolomics

Abstract Background Liquid chromatography–mass spectrometry is widely used in untargeted metabolomics for composition profiling. In multi-run analysis scenarios, features of each run are aligned into consensus features by feature alignment ...