Academic Articles & Research Papers

Health technology and health technology assessment

In addition to the doctor, technology is an essential aspect of healthcare. In many parts of the world, a visit to the doctor does not feel complete without a prescription for a drug. Advanced laboratory and imaging technology is indispensa...

Isolation, characterisation and antibiotic susceptibility of staphylococcal isolates with special reference to methicillin-resistant Staphylococcus aureus from the anterior nares of healthcare workers in A tertiary healthcare centre

Background: Staphylococcus aureus (S. aureus) and its resistant form methicillinresistant S. aureus (MRSA) is one of the most common nosocomial pathogens causing a wide range of infections in humans. The anterior nares are the main ecologic...

In silico analysis of ciprofloxacin analogs as inhibitors of DNA gyrase of Staphylococcus aureus

In this in silico study, thirty-five ciprofloxacin analogs were docked to the active site of DNA gyrase, the prime target of ciprofloxacin type antibiotics. Prior to docking all the structures were optimized using MM2 force field parameters...

Corrigendum: The “Jack-of-all-Trades” Flagellum From Salmonella and E. coli Was Horizontally Acquired From an Ancestral β-Proteobacterium

Gut Microbiota and Metabolome Description of Antibiotic-Treated Neonates From Parturients With Intrauterine Infection

Intrauterine infection is linked to adverse pregnancy outcomes in pregnant women. Neonates from parturients with intrauterine infection are usually treated with antibiotics, but their gut microbiota and metabolome are seldom studied. In thi...

Friends with Social Benefits: Host-Microbe Interactions as a Driver of Brain Evolution and Development?

The tight association of the human body with trillions of colonizing microbes that we observe today is the result of a long evolutionary history. Only very recently have we started to understand how this symbiosis also affects brain functio...

Storage Properties of Double-Layer Films Enriched with <i>Phytolacca americana</i> L. Extract as Active Packaging for African Catfish, with a New Approach to Antioxidant Film Assay and Additional Analysis of <i>P. americana</i> Extract Toxicity on Human Cell Lines

Novel double-layer films based on furcellaran (FUR) and gelatin (GEL) with the addition of Phytolacca americana L. (PA) extract were used as active packaging for African catfish fillets. Films with PA extract have been shown to minimize the...

Convergent Adaptation in the Dominant Global Hospital Clone ST239 of Methicillin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

ABSTRACT Infections caused by highly successful clones of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) are a major public health burden. The globally dominant sequence type 239 (ST239) HA-MRSA clone has persiste...

High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa

ABSTRACT Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the mechanism of non-carbapenemase carbapenem resistance is still unclear. In the current study, we investigated the contributions of point mutations in mex...

The antibiogram of Pus cultures in Federal Tertiary Care Hospital, Islamabad and its utility in antimicrobial stewardshipThe antibiogram of pus cultures in federal tertiary care hospital, Islamabad and its utility in antimicrobial stewardship

Background and Objectives: Antimicrobial resistance has emerged as a significant global health threat. Infections caused by Multi Drug-Resistant (MDR) bacteria pose formidable challenges in terms of treatment options and patient outcomes. P...

Isolation, characterization, and genomic analysis of a novel phage WSPA with lytic activity against Serratia marcescens

ABSTRACT Serratia marcescens is an established pathogen implicated in hospital-acquired infections and is notorious for its propensity to form biofilms on medical devices, leading to persistent environmental contamination and increased infe...

Epstein–Barr Virus-Induced Metabolic Rearrangements in Human B-Cell Lymphomas

Tumor metabolism has been the object of several studies in the past, leading to the pivotal observation of a consistent shift toward aerobic glycolysis (so-called Warburg effect). More recently, several additional investigations proved that...

Prevalence of Obesity and Malnutrition among School-Aged Children of the District Peshawar

ABSTRACTMalnutrition and Obesity are worldwide health phenomena so the aims of the study were to assist the prevalence of obesity and malnutrition among school-aged children of the district Peshawar. Institutional based cross-sectional stud...

Distribution of Soil Extracellular Enzymatic, Microbial, and Biological Functions in the C and N-Cycle Pathways Along a Forest Altitudinal Gradient

The diverse chemical, biological, and microbial properties of litter and organic matter (OM) in forest soil along an altitudinal gradient are potentially important for nutrient cycling. In the present study, we sought to evaluate soil chemi...

Specific egg yolk immunoglobulin as a promising non-antibiotic biotherapeutic product against Acinetobacter baumannii pneumonia infection

Abstract Acinetobacter baumannii is a serious health threat with a high mortality rate. We have already reported prophylactic effects of IgYs raised against OmpA and Omp34 as well as against inactivated whole-cell (IWC) of A. baumannii in a...

KRAS G12V neoantigen specific T cell receptor for adoptive T cell therapy against tumors

Abstract KRAS mutations are broadly recognized as promising targets for tumor therapy. T cell receptors (TCRs) can specifically recognize KRAS mutant neoantigens presented by human lymphocyte antigen (HLA) and mediate T cell responses to el...

In Vitro Evaluation of Polihexanide, Octenidine and NaClO/HClO-Based Antiseptics against Biofilm Formed by Wound Pathogens

Chronic wounds complicated with biofilm formed by pathogens remain one of the most significant challenges of contemporary medicine. The application of topical antiseptic solutions against wound biofilm has been gaining increasing interest a...

Developments in Exploring Fungal Secondary Metabolites as Antiviral Compounds and Advances in HIV-1 Inhibitor Screening Assays

The emergence of drug-resistant Human Immunodeficiency Virus-1 strains against anti-HIV therapies in the clinical pipeline, and the persistence of HIV in cellular reservoirs remains a significant concern. Therefore, there is a continuous ne...

Molecular basis of pathogenesis of emerging viruses infecting aquatic animals

Aquatic vertebrates are very abundant in the world, and they are of tremendous importance in providing global food security and nutrition. However, emergent and resurgent viruses, such as ranavirus (e.g., Rana grylio virus, RGV and Andriasd...

Comparative Phytochemical Analysis of the Aerial Parts of <i>Pelargonium radula</i> and <i>Geranium macrorrhizum</i> Cultivated in Bulgaria Using GC-MS and HPLC

Background: Geraniaceae species are widely used in traditional medicine. Pelargonium radula and Geranium macrorrhizum are aromatic medicinal plants traditionally used in Bulgaria for their antimicrobial, anti-inflammatory, and wound-healing...